Biomedicines,
Год журнала:
2022,
Номер
10(8), С. 1943 - 1943
Опубликована: Авг. 11, 2022
Glioblastoma
(GBM)
is
the
most
lethal
primary
brain
tumor.
With
limited
therapeutic
options,
novel
therapies
are
desperately
needed.
Recent
studies
have
shown
that
GBM
acquires
large
amounts
of
lipids
for
rapid
growth
through
activation
sterol
regulatory
element-binding
protein
1
(SREBP-1),
a
master
transcription
factor
regulates
fatty
acid
and
cholesterol
synthesis,
uptake.
Interestingly,
cells
divert
substantial
quantities
into
lipid
droplets
(LDs),
specific
storage
organelle
neutral
lipids,
to
prevent
lipotoxicity
by
increasing
expression
diacylglycerol
acyltransferase
(DGAT1)
sterol-O-acyltransferase
(SOAT1),
which
convert
excess
acids
triacylglycerol
cholesteryl
esters,
respectively.
In
this
review,
we
will
summarize
recent
progress
on
our
understanding
metabolism
regulation
in
promote
tumor
discuss
strategies
specifically
induce
disrupting
storage,
promising
new
avenue
treating
GBM.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5640 - 5640
Опубликована: Май 22, 2024
The
epidemiological
burden
of
liver
steatosis
associated
with
metabolic
diseases
is
continuously
growing
worldwide
and
in
all
age
classes.
This
condition
generates
possible
progression
damage
(i.e.,
inflammation,
fibrosis,
cirrhosis,
hepatocellular
carcinoma)
but
also
independently
increases
the
risk
cardio-metabolic
cancer.
In
recent
years,
terminological
evolution
from
“nonalcoholic
fatty
disease”
(NAFLD)
to
“metabolic
dysfunction-associated
(MAFLD)
and,
finally,
steatotic
(MASLD)
has
been
paralleled
by
increased
knowledge
mechanisms
linking
local
hepatic)
systemic
pathogenic
pathways.
As
a
consequence,
need
for
an
appropriate
classification
individual
phenotypes
oriented
investigation
innovative
therapeutic
tools.
Besides
well-known
role
lifestyle
change,
number
pharmacological
approaches
have
explored,
ranging
antidiabetic
drugs
agonists
acting
on
gut–liver
axis
at
level
(mainly
farnesoid
X
receptor
(FXR)
agonists,
PPAR
thyroid
hormone
agonists),
anti-fibrotic
anti-inflammatory
agents.
intrinsically
complex
pathophysiological
history
MASLD
makes
selection
single
effective
treatment
major
challenge,
so
far.
this
evolving
scenario,
cooperation
between
different
stakeholders
(including
subjects
risk,
health
professionals,
pharmaceutical
industries)
could
significantly
improve
management
disease
implementation
primary
secondary
prevention
measures.
high
healthcare
search
new,
effective,
safe
pressing
need,
together
accurate
characterization
phenotypes.
Recent
promising
advances
indicate
that
we
may
soon
enter
era
precise
personalized
therapy
MASLD/MASH.
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Фев. 1, 2024
Abstract
Lipid
metabolism
in
cancer
cells
has
garnered
increasing
attention
recent
decades.
Cancer
thrive
hypoxic
conditions,
nutrient
deficiency,
and
oxidative
stress
cannot
be
separated
from
alterations
lipid
metabolism.
Therefore,
exhibit
increased
metabolism,
uptake,
lipogenesis
storage
to
adapt
a
progressively
challenging
environment,
which
contribute
their
rapid
growth.
Lipids
aid
cell
activation.
absorb
lipids
with
the
help
of
transporter
translocase
proteins
obtain
energy.
Abnormal
levels
series
synthases
over-accumulation
tumor
microenvironment
(TME).
reprogramming
plays
an
essential
role
TME.
are
closely
linked
several
immune
phenotypic
transformation.
The
further
promotes
immunosuppression,
leads
escape.
This
event
significantly
affects
progression,
treatment,
recurrence,
metastasis
cancer.
present
review
describes
TME
examines
connection
between
immunotherapy.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 3, 2024
Abstract
BAX
and
BAK
are
proapoptotic
members
of
the
BCL2
family
that
directly
mediate
mitochondrial
outer
membrane
permeabilition
(MOMP),
a
central
step
in
apoptosis
execution.
However,
molecular
architecture
apoptotic
pore
remains
key
open
question
especially
little
is
known
about
contribution
lipids
to
MOMP.
By
performing
comparative
lipidomics
analysis
proximal
environment
isolated
lipid
nanodiscs,
we
find
significant
enrichment
unsaturated
species
nearby
conditions.
We
then
demonstrate
promote
activity
model
membranes,
mitochondria
cellular
systems,
which
further
supported
by
dynamics
simulations.
Accordingly,
fatty
acid
desaturase
FADS2
not
only
enhances
sensitivity,
but
also
activation
cGAS/STING
pathway
downstream
mtDNA
release.
The
correlation
levels
with
sensitization
different
lung
kidney
cancer
cell
lines
co-treatment
acids
supports
relevance
our
findings.
Altogether,
work
provides
an
insight
on
how
local
affects
function
during
apoptosis.
Abstract
KRAS
is
one
of
the
most
mutated
genes,
driving
alternations
in
metabolic
pathways
that
include
enhanced
nutrient
uptaking,
increased
glycolysis,
elevated
glutaminolysis,
and
heightened
synthesis
fatty
acids
nucleotides.
However,
beyond
mechanisms
KRAS-modulated
cancer
metabolisms
remain
incompletely
understood.
In
this
review,
we
aim
to
summarize
current
knowledge
on
KRAS-related
alterations
cells
explore
prevalence
significance
mutation
shaping
tumor
microenvironment
influencing
epigenetic
modification
via
various
molecular
activities.
Given
rely
these
changes
sustain
cell
growth
survival,
targeting
processes
may
represent
a
promising
therapeutic
strategy
for
KRAS-driven
cancers.
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 23, 2025
Neutrophil
extracellular
traps
(NETs)
are
intricate,
web-like
formations
composed
of
DNA,
histones,
and
antimicrobial
proteins,
released
by
neutrophils.
These
structures
participate
in
a
wide
array
physiological
pathological
activities,
including
immune
rheumatic
diseases
damage
to
target
organs.
Recently,
the
connection
between
NETs
cancer
has
garnered
significant
attention.
Within
tumor
microenvironment
metabolism,
exhibit
multifaceted
roles,
such
as
promoting
proliferation
migration
cells,
influencing
redox
balance,
triggering
angiogenesis,
driving
metabolic
reprogramming.
This
review
offers
comprehensive
analysis
link
emphasizing
areas
that
remain
underexplored.
include
interaction
with
mitochondria,
their
effect
on
states
within
tumors,
involvement
reprogramming,
contribution
angiogenesis
tumors.
Such
insights
lay
theoretical
foundation
for
deeper
understanding
role
development.
Moreover,
also
delves
into
potential
therapeutic
strategies
suggests
future
research
directions,
offering
new
perspectives
treatment
other
related
diseases.
Extracellular
vesicles
(EVs),
nanoscale
secreted
by
cells,
have
attracted
considerable
attention
in
recent
years
due
to
their
role
tumor
immunomodulation.
These
facilitate
intercellular
communication
transporting
proteins,
nucleic
acids,
and
other
biologically
active
substances,
they
exhibit
a
dual
development
immune
evasion
mechanisms.
Specifically,
EVs
can
assist
cells
evading
surveillance
attack
impairing
cell
function
or
modulating
immunosuppressive
pathways,
thereby
promoting
progression
metastasis.
Conversely,
also
transport
release
immunomodulatory
factors
that
stimulate
the
activation
regulation
of
system,
enhancing
body's
capacity
combat
malignant
diseases.
This
functionality
presents
promising
avenues
targets
for
immunotherapy.
By
examining
biological
characteristics
influence
on
immunity,
novel
therapeutic
strategies
be
developed
improve
efficacy
relevance
cancer
treatment.
review
delineates
complex
immunomodulation
explores
potential
implications
approaches,
aiming
establish
theoretical
foundation
provide
practical
insights
advancement
future
EVs-based
immunotherapy
strategies.
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
Lipid
metabolism
in
cancer
is
characterized
by
dysregulated
lipid
regulation
and
utilization,
critical
for
promoting
tumor
growth,
survival,
resistance
to
therapy.
Pancreatic
(PC)
a
highly
aggressive
malignancy
of
the
gastrointestinal
tract
that
has
dismal
5-year
survival
rate
less
than
10%.
Given
essential
function
pancreas
digestion,
progression
severely
disrupts
its
function.
Standard
treatments
PC
such
as
surgical
resection,
chemotherapy,
radiotherapy.
However,
these
therapies
often
face
significant
challenges,
including
biochemical
recurrence
drug
resistance.
limitations,
new
therapeutic
approaches
are
being
developed
target
metabolism.
Dysregulation
cholesterol
biosynthesis
alterations
fatty
acids
(FAs),
palmitate,
stearate,
omega-3,
omega-6,
have
been
observed
pancreatic
cancer.
These
lipids
serve
energy
sources,
signaling
molecules,
components
cell
membranes.
Their
accumulation
fosters
an
immunosuppressive
microenvironment
supports
proliferation
metastasis.
Moreover,
dysregulation
within
immune
cells,
particularly
T
impairs
surveillance
weakens
body's
defenses
against
Abnormal
also
contributes
PC.
Despite
targeting
may
offer
promising
strategy.
By
enhancing
peroxidation,
induction
ferroptosis—a
form
regulated
death—could
impair
cells
hinder
disease
progression.
