International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 12 - 12
Опубликована: Дек. 20, 2022
Despite
the
remarkable
progress
in
cancer
treatment
up
to
now,
we
are
still
far
from
conquering
disease.
The
most
substantial
change
after
malignant
transformation
of
normal
cells
into
is
alteration
their
metabolism.
Cancer
reprogram
metabolism
support
elevated
energy
demand
as
well
acquisition
and
maintenance
malignancy,
even
nutrient-poor
environments.
metabolic
alterations,
under
aerobic
conditions,
such
upregulation
glucose
uptake
glycolysis
(the
Warburg
effect),
increase
ROS
(reactive
oxygen
species)
glutamine
dependence,
which
prominent
features
Among
these
high
dependency
has
attracted
serious
attention
research
community.
In
addition,
oncogenic
signaling
pathways
well-known
important
genetic
mutations
play
regulatory
roles,
either
directly
or
indirectly,
central
carbon
identification
convergent
phenotypes
crucial
targeting
cells.
this
review,
investigate
relationship
between
signal
transduction
pathways,
highlight
recent
developments
anti-cancer
therapy
that
target
Cancer Communications,
Год журнала:
2022,
Номер
42(12), С. 1234 - 1256
Опубликована: Сен. 15, 2022
Abstract
Pancreatic
cancer
is
one
of
the
most
serious
health
issues
in
developed
and
developing
countries,
with
a
5‐year
overall
survival
rate
currently
<9%.
Patients
typically
present
advanced
disease
due
to
vague
symptoms
or
lack
screening
for
early
detection.
Surgical
resection
represents
only
chance
cure,
but
treatment
options
are
limited
diseases,
such
as
distant
metastatic
locally
progressive
tumors.
Although
adjuvant
chemotherapy
has
improved
long‐term
outcomes
patients,
its
response
low.
So,
exploring
other
new
treatments
urgent.
In
recent
years,
increasing
evidence
shown
that
lipid
metabolism
can
support
tumorigenesis
progression
well
resistance
through
enhanced
synthesis,
storage,
catabolism.
Therefore,
better
understanding
networks
may
provide
novel
promising
strategies
diagnosis,
prognosis
estimation,
targeted
therapy
pancreatic
patients.
this
review,
we
first
enumerate
discuss
current
knowledge
about
advances
made
regulation
cancer.
addition,
summarize
preclinical
studies
clinical
trials
drugs
targeting
metabolic
systems
Finally,
highlight
challenges
opportunities
pathways
precision
therapies
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Апрель 4, 2022
In
recent
years,
fatty
acid
binding
protein
5
(FABP5),
also
known
as
transporter,
has
been
widely
researched
with
the
help
of
modern
genetic
technology.
Emerging
evidence
suggests
its
critical
role
in
regulating
lipid
transport,
homeostasis,
and
metabolism.
Its
involvement
pathogenesis
various
diseases
such
metabolic
syndrome,
skin
diseases,
cancer,
neurological
is
key
to
understanding
true
nature
protein.
This
makes
FABP5
be
a
promising
component
for
numerous
clinical
applications.
review
summarized
most
advances
research
modulating
cellular
processes,
providing
an
in-depth
analysis
protein’s
biological
properties,
functions,
mechanisms
involved
diseases.
addition,
we
have
discussed
possibility
using
new
diagnostic
biomarker
therapeutic
target
human
shedding
light
on
challenges
facing
future
research.
Biomedicines,
Год журнала:
2022,
Номер
10(8), С. 1943 - 1943
Опубликована: Авг. 11, 2022
Glioblastoma
(GBM)
is
the
most
lethal
primary
brain
tumor.
With
limited
therapeutic
options,
novel
therapies
are
desperately
needed.
Recent
studies
have
shown
that
GBM
acquires
large
amounts
of
lipids
for
rapid
growth
through
activation
sterol
regulatory
element-binding
protein
1
(SREBP-1),
a
master
transcription
factor
regulates
fatty
acid
and
cholesterol
synthesis,
uptake.
Interestingly,
cells
divert
substantial
quantities
into
lipid
droplets
(LDs),
specific
storage
organelle
neutral
lipids,
to
prevent
lipotoxicity
by
increasing
expression
diacylglycerol
acyltransferase
(DGAT1)
sterol-O-acyltransferase
(SOAT1),
which
convert
excess
acids
triacylglycerol
cholesteryl
esters,
respectively.
In
this
review,
we
will
summarize
recent
progress
on
our
understanding
metabolism
regulation
in
promote
tumor
discuss
strategies
specifically
induce
disrupting
storage,
promising
new
avenue
treating
GBM.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Май 31, 2022
Probiotics
have
attracted
much
attention
due
to
their
ability
modulate
host
intestinal
microbe,
participate
in
nutrient
metabolism
or
immunomodulatory.
Both
inflammatory
bowel
disease
(IBD)
and
cancer
are
digestive
system
disease,
which
become
a
global
public
health
problem
unclear
etiology,
difficult
cure,
repeated
attacks.
Disturbed
gut
microbiota
abnormal
lipid
would
increase
the
risk
of
inflammation.
However,
link
between
metabolism,
probiotics,
IBD
is
unclear.
In
this
review,
we
found
that
different
lipids
derivatives
effects
on
microbes.
ω-3
polyunsaturated
fatty
acids
(PUFAs)
docosahexaenoic
acid,
eicosapentaenoic
resolvin
E1,
D
can
inhibit
oxidative
stress
reactive
oxygen
species
activate
NFκB
MAPk
pathway.
While
ω-6
PUFAs
linoleic
acid
arachidonic
be
derived
into
leukotrienes
prostaglandins,
will
aggravate
IBD.
Cholesterol
converted
bile
promote
absorption
affect
microbial
survival
colonization.
At
same
time,
it
affected
by
salt
hydrolase
regulate
blood
lipids.
Low
denstiy
lipoprotein
(LDL)
easily
oxidized
LDL,
thereby
promoting
inflammation,
while
high
(HDL)
has
opposite
effect.
compete
with
microorganisms
for
nutrients
ecological
sites
thus
structure
microbiota.
Moreover,
short
chain
acids,
hydrolase,
superoxide
dismutase,
glutathione,
etc.
conclusion,
probiotics
directly
indirectly
involved
impact
IBD,
provides
possibility
explore
role
improving
health.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 12 - 12
Опубликована: Дек. 20, 2022
Despite
the
remarkable
progress
in
cancer
treatment
up
to
now,
we
are
still
far
from
conquering
disease.
The
most
substantial
change
after
malignant
transformation
of
normal
cells
into
is
alteration
their
metabolism.
Cancer
reprogram
metabolism
support
elevated
energy
demand
as
well
acquisition
and
maintenance
malignancy,
even
nutrient-poor
environments.
metabolic
alterations,
under
aerobic
conditions,
such
upregulation
glucose
uptake
glycolysis
(the
Warburg
effect),
increase
ROS
(reactive
oxygen
species)
glutamine
dependence,
which
prominent
features
Among
these
high
dependency
has
attracted
serious
attention
research
community.
In
addition,
oncogenic
signaling
pathways
well-known
important
genetic
mutations
play
regulatory
roles,
either
directly
or
indirectly,
central
carbon
identification
convergent
phenotypes
crucial
targeting
cells.
this
review,
investigate
relationship
between
signal
transduction
pathways,
highlight
recent
developments
anti-cancer
therapy
that
target
