Biomaterials and Encapsulation Techniques for Probiotics: Current Status and Future Prospects in Biomedical Applications

Nanomaterials, Год журнала: 2023, Номер 13(15), С. 2185 - 2185

Опубликована: Июль 27, 2023

Probiotics have garnered significant attention in recent years due to their potential advantages diverse biomedical applications, such as acting antimicrobial agents, aiding tissue repair, and treating diseases. These live bacteria must exist appropriate quantities precise locations exert beneficial effects. However, viability activity can be significantly impacted by the surrounding tissue, posing a challenge maintain stability target location for an extended duration. To counter this, researchers formulated various strategies that enhance of probiotics encapsulating them within biomaterials. This approach enables site-specific release, overcoming technical impediments encountered during processing application probiotics. A range materials utilized probiotics, several methods employed this encapsulation process. article reviews advancements encapsulated biomaterials, examining materials, methods, effects encapsulation. It also provides overview hurdles faced currently available biomaterial-based probiotic capsules suggests future research directions field. Despite progress achieved date, numerous challenges persist, necessity developing efficient, reproducible Furthermore, there is need design more robust targeted delivery vehicles.

Язык: Английский

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Lactiplantibacillus plantarum A5 alleviates high-fat diet-induced hyperlipidemia via regulating gut microbiota to promote short-chain fatty acids production

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105848 - 105848

Опубликована: Янв. 1, 2025

Язык: Английский

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The roles of gut microbiota and its metabolites in diabetic nephropathy

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июль 27, 2023

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which increases the risk renal failure and causes high global disease burden. Due to lack sustainable treatment, DN has become primary cause end-stage worldwide. Gut microbiota its metabolites exert critical regulatory functions in maintaining host health are associated with many pathogenesis aging-related chronic diseases. Currently, theory gut–kidney axis opened novel angle understand relationship between gut multiple kidney In recent years, accumulating evidence revealed that their play an essential role pathophysiologic processes through axis. this review, we summarize current investigations microbial involvement progression DN, further discuss potential microbiota-targeted therapeutic approaches for DN.

Язык: Английский

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Connecting the Gut Microbiota and Neurodegenerative Diseases: the Role of Bile Acids

Molecular Neurobiology, Год журнала: 2023, Номер 60(8), С. 4618 - 4640

Опубликована: Май 1, 2023

Язык: Английский

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Health Benefits of Prebiotics, Probiotics, Synbiotics, and Postbiotics

Nutrients, Год журнала: 2024, Номер 16(22), С. 3955 - 3955

Опубликована: Ноя. 19, 2024

The trillions of microbes that constitute the human gut microbiome play a crucial role in digestive health, immune response regulation, and psychological wellness. Maintaining microbiota is essential as metabolic diseases are associated with it. Functional food ingredients potentially improving health include prebiotics, probiotics, synbiotics, postbiotics (PPSPs). While probiotics living bacteria provide advantages when ingested sufficiently, prebiotics non-digestible carbohydrates support good bacteria. Synbiotics work together to improve immunity intestinal by combining prebiotics. Postbiotics have also demonstrated numerous advantages, such bioactive molecules created during probiotic fermentation. According recent study, PPSPs can regulate synthesis metabolites, integrity barrier, change composition control illnesses. Additionally, use fecal transplantation (FMT) highlights potential for restoring through modulation, reinforcing benefits enhancing overall well-being. Research has shown several benefits, improved immunological function, alleviation symptoms irritable bowel disease (IBD), decreased severity allergies, antibacterial anti-inflammatory effects. Despite encouraging results, many unanswered questions remain about scope PPSPs' advantages. Extensive research required fully realize these functional components Effective therapeutic prophylactic measures require further investigation into roles PPSPs, specifically their immune-system-modulating, cholesterol-lowering, antioxidant, characteristics.

Язык: Английский

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The Potential Harmful Effects of Genetically Engineered Microorganisms (GEMs) on the Intestinal Microbiome and Public Health

Microorganisms, Год журнала: 2024, Номер 12(2), С. 238 - 238

Опубликована: Янв. 23, 2024

Gut luminal dysbiosis and pathobiosis result in compositional biodiversified alterations the microbial host co-metabolites. The primary mechanism of bacterial evolution is horizontal gene transfer (HGT), acquisition new traits can be achieved through exchange mobile genetic elements (MGEs). Introducing genetically engineered microbes (GEMs) might break harmonized balance intestinal compartment. present objectives are: 1. To reveal role played by GEMs’ transfers changing landscape enteric microbiome eubiosis 2. expand on potential detrimental effects those changes human genome health. A search articles published PubMed/MEDLINE, EMBASE, Scielo from 2000 to August 2023 using appropriate MeSH entry terms was performed. exchanges induce multiple diseases. GEMs change long-term natural pro- or eukaryotic cell inhabitants. worldwide regulatory authority’s safety control not enough protect public Viability, biocontainment, many other aspects are only partially controlled harmful consequences for health should avoided. It important remember that prevention most cost-effective strategy primum non nocere focus.

Язык: Английский

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The efficacy of Lacticaseibacillus paracasei MSMC39-1 and Bifidobacterium animalis TA-1 probiotics in modulating gut microbiota and reducing the risk of the characteristics of metabolic syndrome: A randomized, double-blinded, placebo-controlled study

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317202 - e0317202

Опубликована: Янв. 10, 2025

Modern treatment, a healthy diet, and physical activity routines lower the risk factors for metabolic syndrome; however, this condition is associated with all-cause cardiovascular mortality worldwide. This investigation involved randomized controlled trial, double-blind, parallel study. Fifty-eight participants of syndrome according to inclusion criteria were into two groups given probiotics ( Lacticaseibacillus paracasei MSMC39-1 Bifidobacterium animalis TA-1) (n = 31) or placebo 27). The had mean age 42.29 ± 7.39 43.89 7.54 years in groups, respectively. Stool samples, anthropometric data, blood chemistries taken at baseline 12 weeks. primary outcome was achieved by group as their low-density lipoprotein-cholesterol level dramatically lowered compared (the difference 39.97 26.83 mg/dl, p-value <0.001). Moreover, significant reductions body weight, mass index, waist circumference, systolic pressure, total cholesterol observed volunteers treated placebo. In gut microbiome analysis, results showed statistically differences beta diversity post-intervention group. Blautia , Roseburia Collinsella Ruminococcus among microbiomes that more prevalent addition, exhibited increases predicted functional changes ATP-binding cassette (ABC) transporters, well ribonucleic acid transport, biosynthesis unsaturated fatty acids, glycerophospholipid metabolism, pyruvate metabolism. conclusion, research demonstrated L . B TA-1 have efficacy syndrome.

Язык: Английский

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Inflammatory bowel disease therapeutic strategies by modulation of the microbiota: how and when to introduce pre-, pro-, syn-, or postbiotics?

AJP Gastrointestinal and Liver Physiology, Год журнала: 2022, Номер 323(6), С. G523 - G553

Опубликована: Сен. 27, 2022

Inflammatory bowel diseases (IBD), a heterogeneous group of inflammatory conditions that encompass both ulcerative colitis and Crohn’s disease, represent major public health concern. The etiology IBD is not yet fully understood no cure available, with current treatments only showing long-term effectiveness in minority patients. A need to increase our knowledge on pathophysiology growing, define preventive measures, improve disease outcome, develop new effective lasting treatments. pathogenesis sustained by aberrant immune responses, associated alterations the intestinal epithelial barrier (IEB), modifications enteric nervous system, changes microbiota composition. Currently, most target inflammation but holistic approaches targeting lifestyle diet improvements are emerging. As dysbiosis involved pathogenesis, pre-, pro-, syn-, postbiotics used/tested reduce or strengthen IEB. present review will resume these works, pointing out stage life, duration, environmental should go along microbiota-derived

Язык: Английский

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Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Янв. 25, 2023

In this study, the structure of Pleurotus eryngii polysaccharides (PEPs) was characterized, and mechanism PEP on obesity hyperlipidemia induced by high-fat diet evaluated metabonomic analysis.The PEPs were characterized monosaccharide composition, Fourier transform infrared spectroscopy thermogravimetry. animal experiments, H&E staining used to observe morphological difference epididymal adipose tissue mice in each group. Ultrahigh performance liquid chromatography (UHPLC)-(QE) HFX -mass spectrometry (MS) analyze metabolites serum group related metabolic pathways.The contained nine monosaccharides: 1.05% fucose, 0.30% arabinose, 17.94% galactose, 53.49% glucose, 1.24% xylose, 23.32% mannose, 1.30% ribose, 0.21%galacturonic acid, 1.17% glucuronic acid. The began degrade at 251°C (T0), while maximum thermal degradation rate temperature (Tm) appeared 300°C. results histopathological observation demonstrated that had signifificant hypolipidemic activities. After intervention, profile changed significantly. A total 29 different selected as adjunctive therapy PEPs, for treatment hyperlipidemia-related complications caused a diet. These include amino acids, unsaturated fatty choline, glycerol phospholipids, other endogenous compounds, which can prevent treat regulating acid metabolism, changes pathways such involved citric cycle (TCA cycle).The presented indicate alleviate and, thus, may be functional food adjuvant, providing theoretical basis technical guidance prevention diet-induced hyperlipidemia.

Язык: Английский

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Pretreatment with Bifidobacterium longum BAA2573 ameliorates dextran sulfate sodium (DSS)-induced colitis by modulating gut microbiota

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 6, 2023

Objectives Inflammatory bowel disease (IBD) is a chronic lifelong inflammatory disease. Probiotics such as Bifidobacterium longum are considered to be beneficial the recovery of intestinal inflammation by interaction with gut microbiota. Our goals were define effect exclusive use BAA2573 on dextran sulfate sodium (DSS)-induced colitis, including improvement symptoms, alleviation histopathological damage, and modulation Methods In present study, we pretreated C57BL/6J mice BAA2573, one main components in an over-the-counter (OTC) probiotic mixture BIFOTO capsule, before modeling DSS. 16S rDNA sequencing liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based non-targeted metabolomic profiling performed collected feces. Results We found that pretreatment given gavage significantly improved symptoms damage DSS-induced colitis mice. After intervention, 57 genera 39 metabolites altered. Pathway enrichment analysis demonstrated starch sucrose metabolism, vitamin B6 sphingolipid metabolism may contribute ameliorating colitis. Moreover, revealed microbiome interrelated intervention group, while Alistipes was core genus. Conclusion study demonstrates impact microbiota reveals possible novel adjuvant therapy for IBD patients.

Язык: Английский

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