The Journal of Immunology,
Год журнала:
2023,
Номер
211(9), С. 1308 - 1319
Опубликована: Сен. 18, 2023
Gain-of-function
polymorphisms
in
the
transcription
factor
IFN
regulatory
5
(IRF5)
are
associated
with
an
increased
risk
of
developing
systemic
lupus
erythematosus.
Global
homozygous
or
heterozygous
deficiency
IRF5
from
birth
confers
protection
many
mouse
models.
However,
less
is
known
about
effects
targeting
after
autoimmunity
has
already
developed.
This
important
point
to
clarify
when
considering
as
a
potential
therapeutic
target
lupus.
In
this
study,
we
demonstrate
that
genetic
reduction
expression
disease
initiation
reduces
severity
FcγRIIB-/-
Y-linked
autoimmune
accelerating
model.
Reduction
resulted
decrease
splenomegaly
and
lymphadenopathy
splenic
B
cell
activation
plasmablast
numbers.
Splenic
T
differentiation
were
also
impacted
demonstrated
by
increase
number
naive
CD4+
CD8+
cells
memory/effector
cells.
Although
serum
antinuclear
autoantibody
levels
not
altered,
led
decreased
immune
complex
deposition
complement
activation,
diminished
glomerular
interstitial
disease,
infiltrate
kidney.
Mechanistically,
myeloid
kidney
produced
inflammatory
cytokines
TLR7
TLR9
activation.
Overall,
during
active
process
sufficient
reduce
severity.
Our
data
support
consideration
suggest
approaches
erythematosus
may
need
impact
activity
both
systemically
organs.
Cells,
Год журнала:
2025,
Номер
14(9), С. 648 - 648
Опубликована: Апрель 29, 2025
Immunocompetent
cells
of
B
lineage
function
in
the
humoral
immunity
system
adaptive
immune
responses.
differentiate
into
plasmacytes
upon
antigen-induced
activation
and
produce
different
subclasses
immunoglobulins/antibodies.
Secreted
immunoglobulins
not
only
interact
with
pathogens
to
inactivate
neutralize
them,
but
also
involve
complement
exert
antibacterial
activities
trigger
opsonization.
Endometrium
is
a
mucosal
tissue
that
lines
mammalian
uterus
indispensable
for
establishment
successful
pregnancy.
The
lymphocytes
cell
are
minority
human
cycling
endometrium.
Human
endometrial
have
therefore
been
understudied
so
far.
However,
disorders
female
reproductive
tract,
including
chronic
endometritis
endometriosis,
highlighted
importance
further
research
on
lineage.
This
review
aims
revisit
lymphopoiesis,
maturation,
commitment,
survival
cells,
shedding
light
their
physiological
pathological
implications
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 11, 2023
Germinal
centers
(GCs)
are
distinct
microanatomical
structures
that
form
in
the
secondary
lymphoid
organs
of
endothermic
vertebrates
(i.e.,
mammals
and
some
birds).
Within
GCs,
B
cells
undergo
a
Darwinian
selection
process
to
identify
clones
which
can
respond
pathogen
insult
as
well
affinity
mature
cell
repertoire.
The
GC
response
ultimately
generates
memory
bone
marrow
plasma
facilitate
humoral
immunological
memory,
basis
for
successful
vaccination
programs.
GCs
have
not
been
observed
ectothermic
jawed
fishes,
reptiles,
amphibians).
However,
abundant
research
over
past
decades
has
indicated
these
organisms
produce
antigen
specific
responses
degree
maturation.
This
review
examines
data
demonstrating
fundamentals
may
be
more
conserved
across
vertebrate
phylogeny
than
previously
anticipated.
Further,
both
conventional
mammalian
model
systems
comparative
models
raises
question
what
evolutionary
benefit
provide
endotherms
if
they
seemingly
unnecessary
generating
basic
functional
components
adaptive
immune
responses.
Allergy,
Год журнала:
2023,
Номер
78(12), С. 3103 - 3117
Опубликована: Июль 7, 2023
The
existence
of
long-lived
IgE
antibody-secreting
cells
(ASC)
is
contentious,
with
the
maintenance
sensitization
by
continuous
differentiation
short-lived
International Immunology,
Год журнала:
2024,
Номер
36(7), С. 339 - 352
Опубликована: Март 2, 2024
Bone
marrow
is
a
dynamic
organ
composed
of
stem
cells
that
constantly
receive
signals
from
stromal
and
other
hematopoietic
in
the
niches
bone
to
maintain
hematopoiesis
generate
immune
cells.
Perturbation
microenvironment
by
infection
inflammation
affects
may
affect
cell
development.
Little
known
about
effect
malaria
on
govern
(HSC)
niche.
In
this
study,
we
demonstrate
mesenchymal
CXCL12-abundant
reticular
(CAR)
population
reduced
during
acute
infection.
The
reduction
CXCL12
interleukin-7
impairs
lymphopoietic
niche,
leading
depletion
common
lymphoid
progenitors,
B
mature
cells,
including
plasma
marrow.
We
found
interferon-γ
(IFNγ)
responsible
for
upregulation
Sca1
CAR
yet
decline
populations
IFNγ-independent.
contrast
populations,
HSCs
multipotent
progenitors
increased
with
expansion
myelopoiesis
erythropoiesis,
indicating
bias
differentiation
These
findings
suggest
host
immunity
modulating
Immunity,
Год журнала:
2024,
Номер
57(3), С. 600 - 611.e6
Опубликована: Март 1, 2024
Plasma
cells
that
emerge
after
infection
or
vaccination
exhibit
heterogeneous
lifespans;
most
survive
for
days
to
months,
whereas
others
persist
decades,
providing
antigen-specific
long-term
protection.
We
developed
a
mathematical
framework
explore
the
dynamics
of
plasma
cell
removal
and
its
regulation
by
survival
factors.
Analyses
antibody
persistence
following
hepatitis
A
B
HPV
revealed
specific
patterns
longevity
heterogeneity
within
between
responses,
implying
this
process
is
fine-tuned
near
critical
"flat"
state
two
dynamic
regimes.
This
reflects
tuning
rates
underlying
regulatory
network
highly
sensitive
variation
in
parameters,
which
amplifies
lifespan
differences
cells.
propose
fine-tuning
generic
outcome
competition
over
shared
signals,
with
competition-based
mechanism
unifying
explanation
wide
range
experimental
observations,
including
accumulation
effects
factor
deletion.
Our
theory
testable,
we
provide
predictions.
