Biomimetic nanoparticles functionalized by macrophage membrane ameliorate heart failure in mouse and human cardiac organoid model
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 159447 - 159447
Опубликована: Янв. 1, 2025
Язык: Английский
Macrophage Membrane-Cloaked ROS-Responsive Albumin Nanoplatforms for Targeted Delivery of Curcumin to Alleviate Acute Liver Injury
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Developing
low-toxicity,
high-efficacy,
and
fast-acting
strategies
to
manage
acute
liver
injury
(ALI)
is
critical
due
its
rapid
progression
potential
for
severe
outcomes.
Curcumin
(CUR)
has
shown
promise
in
ALI
therapy
ability
modulate
the
inflammatory
microenvironment
by
scavenging
reactive
oxygen
species
(ROS).
Nevertheless,
CUR
highly
hydrophobic
limiting
bioavailability
effective
vivo
transport,
which
hinders
further
application.
In
this
study,
we
developed
an
microenvironment-targeted
drug
delivery
system
covalently
coupling
human
serum
albumin
(HSA)
with
ROS-sensitive
thioketal
linkers
loading
it
form
nanoparticles
(HSA-TK/CUR).
These
were
then
coated
a
macrophage
membrane
(CM@HSA-TK/CUR),
resulting
negatively
charged
spherical
particles
(≈
−23.26
mV)
average
particle
size
of
around
165
nm.
ROS
responsiveness
was
confirmed
through
release
assays
enhanced
depletion
demonstrated
Diacetyldichlorofluorescein
(DCFH-DA)
detection
experiments.
CM@HSA-TK/CUR
treatment
resulted
94.7%
reduction
levels
cells.
addition,
cellular
uptake
distribution
experiments
that
camouflaging
HSA-TK/CUR
membranes
significantly
targeting
microenvironment.
The
findings
revealed
rapidly
accumulated
injured
within
6
h,
inhibited
production
pro-inflammatory
factors
(IL-1β,
IL-6,
TNF-α),
shifted
polarization
from
M1
M2
vivo,
protected
hepatocytes
oxidative
stress-associated
cell
death,
attenuating
response
mice.
conclusion,
excellent
treating
mice
ALI.
Язык: Английский
Ferroptosis as a key player in the pathogenesis and intervention therapy in liver injury: focusing on drug-induced hepatotoxicity
Bahaa Ibrahim Saeed,
Subasini Uthirapathy,
Aziz Kubaev
и другие.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
M X Huang,
Xinxin Liu,
Yingcong Ren
и другие.
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 5709 - 5728
Опубликована: Дек. 1, 2024
In
intensive
care
units,
acute
lung
injury
(ALI)
is
a
syndrome
that
frequently
encountered.
It
associated
with
high
rate
of
morbidity
and
mortality.
Despite
the
extensive
research
conducted
by
medical
community
on
its
treatment,
no
specific
effective
drugs
have
been
identified.
Quercetin
natural
flavonoid
many
biological
activities
pharmacological
effects.
Research
indicates
can
modulate
various
targets
signaling
pathways,
inhibiting
oxidative
stress,
inflammatory
responses,
ferroptosis,
apoptosis,
fibrosis,
bacterial
viral
infections
in
ALI.
This
regulation
suggests
potential
therapeutic
application
for
condition.
Currently,
there
comprehensive
review
addressing
treatment
paper
begins
classification
ALI,
followed
detailed
summary
mechanisms
through
which
may
treat
ALI
to
evaluate
as
novel
option.
Язык: Английский
Macrophage Membrane-Coated Nanoparticles for the Delivery of Natamycin Exhibit Increased Antifungal and Anti-Inflammatory Activities in Fungal Keratitis
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(44), С. 59777 - 59788
Опубликована: Окт. 28, 2024
This
study
aims
to
explore
the
efficacy
and
safety
of
macrophage
membrane-coated
nanoparticles
for
delivery
natamycin
(NAT)
in
therapy
fungal
keratitis
(FK).
Macrophage
membranes
were
isolated
identified
by
immunofluorescence
staining
(IFS).
NAT
was
encapsulated
into
poly(lactic-co-glycolic
acid)
(PLGA).
Fungal
stimulated
(M1)
or
unstimulated
(M)
separately
mixed
sonicated
with
PLGA
nanoparticles.
The
biocompatible
(PLGA-NAT,
PLGA-NAT@M,
PLGA-NAT@M1)
characterized
zeta-sizer
analysis,
transmission
electron
microscopy
(TEM),
Western
blot.
Drug
encapsulation
loading
efficiency
release
detected
ultraviolet
spectrophotometry.
cytotoxicity,
ocular
surface
toxicity
irritability,
systemic
different
concentrations
assessed.
In
vitro,
we
examined
antifungal
properties
eye
retention
time,
drug
release,
curative
effects
on
FK
evaluated
vitro
vivo.
IFS
results
showed
separation
membrane
nucleus.
prepared
had
a
typical
"core–shell"
structure
uniform
nanometer
size,
proteins
retained
allowing
exert
functional
macrophage.
efficiencies
PLGA-NAT@M
PLGA-NAT@M1
7.6
6.7%,
respectively.
51.2
41.5%,
could
gradually
reduce
clearance
surface.
enhanced
activity
PLGA-NAT.
Furthermore,
coated
increased
biocompatibility
decreased
corneal
vivo,
significantly
alleviated
severity
FK.
PLGA@M
PLGA@M1
reduced
protein
levels
inflammatory
cytokines
after
stimulation.
has
good
physical
biosafety.
It
evade
clearance,
gradually,
achieve
high
anti-inflammatory
clinically
have
application
potential
treatment
Язык: Английский