International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 241 - 241
Опубликована: Дек. 30, 2024
Alzheimer’s
disease
(AD)
poses
a
significant
worldwide
health
challenge,
requiring
novel
approaches
for
improved
models
and
treatment
development.
This
comprehensive
review
emphasises
the
systematic
development
improvement
of
biomimetic
brain
environment
to
address
shortcomings
existing
AD
enhance
efficiency
screening
potential
drug
treatments.
We
identify
drawbacks
in
traditional
emphasise
necessity
more
physiologically
accurate
systems
through
an
in-depth
analysis
current
literature.
aims
study
advanced
model
that
accurately
replicates
key
pathophysiological
aspects
using
cutting-edge
biomaterials
microenvironment
design.
Incorporating
biomolecular
elements
like
Tau
proteins
beta-amyloid
(Aβ)
plaques
improve
accuracy
illustrating
mechanisms.
The
expected
results
involve
creating
solid
foundation
high-throughput
with
enhanced
scalability,
translational
significance,
possibility
speeding
up
discovery.
Thus,
this
fills
gaps
modelling
shows
precise
efficient
treatments
AD.
Advanced Engineering Materials,
Год журнала:
2023,
Номер
25(21)
Опубликована: Авг. 29, 2023
Stimuli‐responsive
polymers
(SRPs)
are
special
types
of
soft
materials,
which
have
been
extensively
used
for
developing
flexible
actuators,
robots,
wearable
devices,
sensors,
self‐expanding
structures,
and
biomedical
thanks
to
their
ability
change
shapes
functional
properties
in
response
external
stimuli
including
light,
humidity,
heat,
pH,
electric
field,
solvent,
magnetic
field
or
combinations
two
more
these
stimuli.
In
recent
years,
additive
manufacturing
(AM)
aka
3D
printing
technology
SRPs,
also
known
as
4D
printing,
has
gained
phenomenal
attention
different
engineering
fields,
its
unique
develop
complex,
personalized,
innovative
undergo
twisting,
elongating,
swelling,
rolling,
shrinking,
bending,
spiraling,
other
complex
morphological
transformations.
Herein,
an
effort
made
provide
insightful
information
about
the
AM
techniques,
type
applications
including,
but
not
limited
tissue
engineering,
bionics,
construction,
smart
textiles.
This
article
incorporates
current
challenges
prospects,
hoping
basis
utilization
this
fields.
It
is
expected
that
amalgamation
with
SRPs
would
unparalleled
advantages
arenas.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2441 - 2467
Опубликована: Март 1, 2024
Abstract:
New
nanotechnology
strategies
for
enhancing
drug
delivery
in
brain
disorders
have
recently
received
increasing
attention
from
designers.
The
treatment
of
neurological
conditions,
including
tumors,
stroke,
Parkinson's
Disease
(PD),
and
Alzheimer's
disease
(AD),
may
be
greatly
influenced
by
nanotechnology.
Numerous
studies
on
neurodegeneration
demonstrated
the
effective
application
nanomaterials
illnesses.
Nanocarriers
(NCs)
made
it
easier
to
deliver
drugs
precisely
where
they
are
needed.
Thus,
most
use
is
various
diseases,
as
this
amplifies
overall
impact
medication
emphasizes
significance
nanotherapeutics
through
gene
therapy,
enzyme
replacement
blood-barrier
mechanisms.
Recent
advances
led
development
multifunctional
nanotherapeutic
agents,
a
promising
disorders.
This
novel
method
reduces
side
effects
improves
outcomes.
review
critically
assesses
efficient
nano-based
systems
light
obstacles
outstanding
achievements.
that
transfer
medications
across
blood-brain
barrier
nano-assisted
therapies,
nano-immunotherapy,
nano-gene
nano
scaffolds,
3D
6D
printing,
been
widely
explored
study
aimed
evaluate
existing
literature
regarding
can
penetrate
(BBB)
therapeutic
agents
treat
Keywords:
delivery,
nanomedicine,
nano-therapeutics,
nanocarriers,
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(19), С. 4584 - 4612
Опубликована: Янв. 1, 2024
Recent
advancements
pertaining
to
the
application
of
3D,
4D,
5D,
and
6D
bioprinting
in
cancer
research
are
discussed,
focusing
on
important
challenges
future
perspectives.
Advances in medical education, research, and ethics (AMERE) book series,
Год журнала:
2025,
Номер
unknown, С. 119 - 146
Опубликована: Янв. 10, 2025
Speech
impairment
presents
a
significant
challenge
for
aged
and
chronically
ill
individuals.
Emerging
assistive
technologies
offer
promising
solutions
to
improve
their
communication
abilities.
This
discussion
explores
established
options
like
Augmentative
Alternative
Communication
(AAC)
devices
cutting-edge
approaches
Brain-Computer
Interfaces
(BCIs).
Neuroprosthetics,
field
merging
neuroscience
biomedical
engineering,
aims
replace
or
modulate
damaged
parts
of
the
nervous
system.
We
delved
into
potential
optogenetics,
neuroengineering
devices,
biosensors,
highlighting
contributions
future
advancements
in
speech
assistance.
The
dialogue
emphasized
importance
comprehensive
approach,
combining
with
ongoing
research
on
areas
synthetic
biology.
multi-faceted
approach
holds
key
empowering
speech-impaired
individuals
fostering
improved
communication.
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Июль 2, 2024
Glioblastoma
poses
a
formidable
challenge
among
primary
brain
tumors:
its
tumorigenic
stem
cells,
capable
of
self-renewal,
proliferation,
and
differentiation,
contribute
substantially
to
tumor
initiation
therapy
resistance.
These
glioblastoma
cells
(GSCs),
resembling
conventional
progenitor
adopt
pathways
critical
for
tissue
development
repair,
promoting
uninterrupted
expansion.
Long
non-coding
RNAs
(lncRNAs),
substantial
component
the
human
transcriptome,
have
garnered
considerable
interest
their
pivotal
roles
in
normal
physiological
processes
cancer
pathogenesis.
They
display
cell-
or
tissue-specific
expression
patterns,
extensive
investigations
highlighted
impact
on
regulating
GSC
properties
cellular
thus
offering
promising
avenues
therapeutic
interventions.
Consequently,
lncRNAs,
with
ability
exert
regulatory
control
over
progression,
emerged
as
targets
innovative
therapies.
This
review
explores
notable
examples
GSC-associated
lncRNAs
elucidates
functional
driving
progression.
Additionally,
we
delved
deeper
into
utilizing
3D
