Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 6, 2025
Traumatic
brain
injury
(TBI)
represents
a
significant
global
public
health
issue,
with
effective
management
posing
numerous
challenges.
The
pathophysiology
of
TBI
is
typically
categorized
into
two
phases:
primary
and
secondary
injuries.
Secondary
involves
pathophysiological
mechanisms
such
as
blood-brain
barrier
(BBB)
disruption,
mitochondrial
dysfunction,
oxidative
stress,
inflammatory
responses.
Current
pharmacological
strategies
often
encounter
obstacles
in
treating
effectively,
primarily
due
to
challenges
BBB
penetration,
inadequate
target
site
accumulation,
off-target
toxicity.
Versatile
hydrogels
nanoparticles
offer
potential
solutions
these
limitations.
This
review
discusses
recent
progress
utilizing
for
treatment
over
the
past
5
years,
highlighting
their
relevance
underlying
pathophysiology.
Hydrogels
demonstrate
substantial
promise
addressing
injury,
providing
broad
spectrum
future
therapeutic
opportunities.
Язык: Английский
Application of stimuli-responsive hydrogel in brain disease treatment
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июль 18, 2024
Treating
brain
diseases
presents
significant
challenges
due
to
neuronal
degeneration,
inflammation,
and
the
intricate
nature
of
brain.
Stimuli-responsive
hydrogels,
designed
closely
resemble
brain’s
extracellular
matrix,
have
emerged
as
promising
candidates
for
controlled
drug
delivery
tissue
engineering.
These
hydrogels
unique
ability
encapsulate
therapeutic
agents
release
them
in
a
manner
when
triggered
by
environmental
stimuli.
This
property
makes
particularly
suitable
delivering
drugs
precisely
targeted
areas
brain,
while
minimizing
collateral
damage
healthy
tissue.
Their
preclinical
success
treating
various
animal
studies
underscores
their
translational
potential
human
disease
treatment.
However,
deeper
understanding
long-term
behavior,
biodistribution,
biocompatibility
within
remains
crucial.
Furthermore,
exploring
novel
hydrogel
systems
combinations
is
paramount
advancing
towards
more
effective
treatments.
review
summarizes
latest
advancements
this
field
over
past
5
years,
specifically
highlighting
progress
with
stimuli-responsive
diseases.
Язык: Английский
Hydrogel in the treatment of traumatic brain injury
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
Язык: Английский
The induction of metallothionein by sulforaphane reduces iron toxicity via Nrf2
Journal of Applied Biology & Biotechnology,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Iron
is
essential
for
cell
survival;
however,
iron
overload
disorders
lead
to
excess
deposition,
which
can
induce
oxidative
stress
and
reduce
viability.
Rapid
chelation
of
prevent
critical
avoiding
the
negative
impacts
overload.
Iron-chelating
agents
are
often
used
treat
overload;
most
these
have
adverse
side
effects
a
narrow
scope
applications.
Recently,
many
classes
phytochelators
with
additional
antioxidant
activities
been
developed
clinical
use.
Sulforaphane
(SFN)
has
potent
cytoprotective
activities,
but
its
role
in
metabolism
never
reported.
Thus,
we
assessed
protective
SFN
against
iron-induced
toxicity
hepatoma
Hep3B
cells
examined
mechanism.
In
this
study,
Fe
ions
increased
intracellular
ROS
levels
decreased
An
transcription
factor
called
NF-E2-related
2
(Nrf2)
was
activated
by
treatment.
chelator
deferoxamine
(DFO)
reduced
did
not
affect
Next,
showed
that
improved
viability
further
enhancing
Nrf2
via
phosphoinositide
3-kinase
(PI3K)
pathway.
Mechanistically,
transcriptionally
metallothionein
(MT),
metal-binding
protein.
Overexpression
MT
protected
from
toxicity,
similar
activities.
These
results
suggest
induction
mRNA
mechanisms
contributing
disorders.
Язык: Английский