Chitosan alchemy: transforming tissue engineering and wound healing
RSC Advances,
Год журнала:
2024,
Номер
14(27), С. 19219 - 19256
Опубликована: Янв. 1, 2024
Chitosan,
a
biopolymer
acquired
from
chitin,
has
emerged
as
versatile
and
favorable
material
in
the
domain
of
tissue
engineering
wound
healing.
Язык: Английский
Heparin and Gelatin Co-Functionalized Polyurethane Artificial Blood Vessel for Improving Anticoagulation and Biocompatibility
Bioengineering,
Год журнала:
2025,
Номер
12(3), С. 304 - 304
Опубликована: Март 18, 2025
The
primary
challenges
in
the
tissue
engineering
of
small-diameter
artificial
blood
vessels
include
inadequate
mechanical
properties
and
insufficient
anticoagulation
capabilities.
To
address
these
challenges,
urea-pyrimidone
(Upy)-based
polyurethane
elastomers
(PIIU-B)
were
synthesized
by
incorporating
quadruple
hydrogen
bonding
within
polymer
backbone.
synthesis
process
employed
poly(L-lactide-ε-caprolactone)
(PLCL)
as
soft
segment,
while
di-(isophorone
diisocyanate)-Ureido
pyrimidinone
(IUI)
isophorone
diisocyanate
(IPDI)
utilized
hard
segment.
resulting
PIIU-B
vessel
with
a
diameter
4
mm
was
fabricated
using
electrospinning
technique,
achieving
an
optimized
IUI/IPDI
composition
ratio
1:1.
Enhanced
multiple
bonds,
exhibited
robust
elastic
modulus
12.45
MPa,
extracellular
matrix
(ECM)-mimetic
nanofiber
morphology,
high
porosity
41.31%.
Subsequently,
underwent
dual-functionalization
low-molecular-weight
heparin
gelatin
via
ultraviolet
(UV)
crosslinking
(designated
PIIU-B@LHep/Gel),
which
conferred
superior
biocompatibility
exceptional
properties.
study
revealed
improved
anti-platelet
adhesion
characteristics
well
prolonged
activated
partial
thromboplastin
time
(APTT)
157.2
s
thrombin
(TT)
64.2
vitro.
Following
seven-day
subcutaneous
implantation,
PIIU-B@LHep/Gel
excellent
biocompatibility,
evidenced
complete
integration
surrounding
peri-implant
tissue,
significant
cell
infiltration,
collagen
formation
vivo.
Consequently,
polyurethane-based
vessels,
reinforced
bonds
dual-functionalized
gelatin,
present
promising
candidates
for
vascular
engineering.
Язык: Английский
Fabrication and biological properties of electrospun chitosan/polyethylene oxide nanofibrous scaffolds loaded with the Arctium lappa L. extract
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142544 - 142544
Опубликована: Март 1, 2025
Язык: Английский
A Multifunctional Hydrogel for Infected Chronic Wounds Management: Integrated pH Sensing, Photothermal Therapy, and Ion Release
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
ABSTRACT
Chronic
wound
healing
is
often
compromised
by
bacterial
infection,
and
pH
changes
strongly
correlate
with
infection.
Therefore,
the
development
of
dressings
capable
real‐time
monitoring,
antimicrobial
activity,
tissue
repair
crucial
for
effective
management
infected
chronic
wounds.
This
study
reports
a
novel
multifunctional
composite
hydrogel
(GM‐C‐mBG@P)
synthesized
incorporating
microwave‐synthesized
carbon
quantum
dots
(CQDs)
polydopamine‐modified
mesoporous
bioactive
glass
nanoparticles
(mBG@P)
into
modified
gelatin
methacryloyl
(GelMA).
The
incorporated
polydopamine
(PDA)
confers
excellent
photothermal
properties
to
hydrogel,
enabling
activity.
Under
360
nm
UV
excitation,
fluorescence
intensity
CQDs
in
GM‐C‐mBG@P
exhibits
strong
linear
correlation
pH,
monitoring.
Furthermore,
mBG@P
can
gradually
dissolve
calcium,
silicon,
boron,
other
functional
ions
enhance
bioactivity
functionality
accelerate
healing.
These
findings
suggest
that
has
potential
serve
as
promising
dressing
treatment
Язык: Английский
A multi-purpose dressing based on resveratrol-loaded ionic liquids/gelatin methacryloyl hydrogel for enhancing diabetic wound healing
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
283, С. 136773 - 136773
Опубликована: Окт. 21, 2024
Язык: Английский
Injectable GelMA Hydrogel Microspheres with Sustained Release of Platelet‐Rich Plasma for the Treatment of Thin Endometrium
Small,
Год журнала:
2024,
Номер
20(47)
Опубликована: Авг. 29, 2024
Abstract
Platelet‐rich
plasma
(PRP)
intrauterine
infusion
has
been
demonstrated
to
be
effective
in
treating
thin
endometrium
and
achieving
pregnancy.
However,
the
rapid
release
of
growth
factors
limits
its
effectiveness
clinical
applications,
thus,
multiple
infusions
are
often
required
achieve
therapeutic
efficacy.
In
this
study,
a
GelMA
hydrogel
microsphere
biomaterial
is
developed
using
droplet
microfluidics
modify
delivery
mode
PRP
thus
prolong
duration
action.
Its
biocompatibility
confirmed
through
both
vivo
vitro
studies.
Cell
experiments
show
that
PRP‐loaded
microspheres
significantly
enhance
cell
proliferation,
migration,
angiogenesis.
effects
on
repairing
restoring
fertility
mice
could
impact
triple
infusions.
Further
mechanistic
investigations
reveal
facilitate
endometrial
repair
by
regulating
expression
E2Fs,
group
transcription
factors.
This
study
demonstrates
action,
enabling
functional
reconstruction.
design
avoids
repeated
injections
clinic,
reduces
number
patient
visits,
provides
new
avenue
for
treatment
endometrium.
Язык: Английский
Alginate-based systems: advancements in drug delivery and wound healing
Abdulaziz S. Al-Roujayee,
Erina Hilaj,
A. Deepak
и другие.
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 29
Опубликована: Июль 22, 2024
Язык: Английский
Polylysine in biomedical applications: from composites to breakthroughs
Biomedical Materials,
Год журнала:
2024,
Номер
19(6), С. 062002 - 062002
Опубликована: Окт. 9, 2024
Polylysine-based
composites
have
emerged
as
promising
materials
in
biomedical
applications
due
to
their
versatility,
biocompatibility,
and
tunable
properties.
In
drug
delivery,
polylysine-based
furnish
a
novel
platform
for
targeted
controlled
release
of
therapeutic
agents.
Their
high
loading
capacity
capability
encapsulate
diverse
drugs
make
them
ideal
candidates
addressing
challenges
such
stability
kinetics.
Additionally,
biocompatibility
ensures
minimal
cytotoxicity,
vital
applications.
They
also
hold
substantial
potential
tissue
engineering
by
providing
scaffold
with
mechanical
characteristics
surface
properties,
can
support
cell
adhesion,
proliferation,
differentiation.
Furthermore,
bioactive
nature
facilitates
cellular
interactions,
promoting
regeneration
integration.
Wound
healing
is
another
area
where
show
promise.
antimicrobial
properties
help
prevent
infections,
while
ability
foster
migration
proliferation
accelerates
the
wound
procedure.
Incorporation
growth
factors
or
other
molecules
further
enhances
effectiveness.
biosensing
applications,
they
serve
robust
substrates
immobilizing
biomolecules
sensing
elements.
area-to-volume
ratio
excellent
improve
sensor
sensitivity
selectivity,
enabling
accurate
detection
biomarkers
analytes
biological
samples.
offer
contrast
agents
bioimaging,
aiding
diagnosis
monitoring
diseases.
Overall,
represent
versatile
research
clinical
practice,
holding
great
promise
various
healthcare
challenges.
.
Язык: Английский