Polylysine in biomedical applications: from composites to breakthroughs DOI
Deepak Arun Annamalai,

Erina Hilaj,

Manisha Singh

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(6), P. 062002 - 062002

Published: Oct. 9, 2024

Polylysine-based composites have emerged as promising materials in biomedical applications due to their versatility, biocompatibility, and tunable properties. In drug delivery, polylysine-based furnish a novel platform for targeted controlled release of therapeutic agents. Their high loading capacity capability encapsulate diverse drugs make them ideal candidates addressing challenges such stability kinetics. Additionally, biocompatibility ensures minimal cytotoxicity, vital applications. They also hold substantial potential tissue engineering by providing scaffold with mechanical characteristics surface properties, can support cell adhesion, proliferation, differentiation. Furthermore, bioactive nature facilitates cellular interactions, promoting regeneration integration. Wound healing is another area where show promise. antimicrobial properties help prevent infections, while ability foster migration proliferation accelerates the wound procedure. Incorporation growth factors or other molecules further enhances effectiveness. biosensing applications, they serve robust substrates immobilizing biomolecules sensing elements. area-to-volume ratio excellent improve sensor sensitivity selectivity, enabling accurate detection biomarkers analytes biological samples. offer contrast agents bioimaging, aiding diagnosis monitoring diseases. Overall, represent versatile research clinical practice, holding great promise various healthcare challenges. .

Language: Английский

Chitosan alchemy: transforming tissue engineering and wound healing DOI Creative Commons
Sheersha Pramanik,

Akanksha Aggarwal,

Ammar Kadi

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(27), P. 19219 - 19256

Published: Jan. 1, 2024

Chitosan, a biopolymer acquired from chitin, has emerged as versatile and favorable material in the domain of tissue engineering wound healing.

Language: Английский

Citations

14
Heparin and Gelatin Co-Functionalized Polyurethane Artificial Blood Vessel for Improving Anticoagulation and Biocompatibility DOI Creative Commons
Jimin Zhang,

Jingzhe Guo,

Junxian Zhang

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(3), P. 304 - 304

Published: March 18, 2025

The primary challenges in the tissue engineering of small-diameter artificial blood vessels include inadequate mechanical properties and insufficient anticoagulation capabilities. To address these challenges, urea-pyrimidone (Upy)-based polyurethane elastomers (PIIU-B) were synthesized by incorporating quadruple hydrogen bonding within polymer backbone. synthesis process employed poly(L-lactide-ε-caprolactone) (PLCL) as soft segment, while di-(isophorone diisocyanate)-Ureido pyrimidinone (IUI) isophorone diisocyanate (IPDI) utilized hard segment. resulting PIIU-B vessel with a diameter 4 mm was fabricated using electrospinning technique, achieving an optimized IUI/IPDI composition ratio 1:1. Enhanced multiple bonds, exhibited robust elastic modulus 12.45 MPa, extracellular matrix (ECM)-mimetic nanofiber morphology, high porosity 41.31%. Subsequently, underwent dual-functionalization low-molecular-weight heparin gelatin via ultraviolet (UV) crosslinking (designated PIIU-B@LHep/Gel), which conferred superior biocompatibility exceptional properties. study revealed improved anti-platelet adhesion characteristics well prolonged activated partial thromboplastin time (APTT) 157.2 s thrombin (TT) 64.2 vitro. Following seven-day subcutaneous implantation, PIIU-B@LHep/Gel excellent biocompatibility, evidenced complete integration surrounding peri-implant tissue, significant cell infiltration, collagen formation vivo. Consequently, polyurethane-based vessels, reinforced bonds dual-functionalized gelatin, present promising candidates for vascular engineering.

Language: Английский

Citations

0
Fabrication and biological properties of electrospun chitosan/polyethylene oxide nanofibrous scaffolds loaded with the Arctium lappa L. extract DOI

Dehghan Navaei Ardeh,

Mohammad Sadegh Nourbakhsh,

Arash Montazeri

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142544 - 142544

Published: March 1, 2025

Language: Английский

Citations

0
A Multifunctional Hydrogel for Infected Chronic Wounds Management: Integrated pH Sensing, Photothermal Therapy, and Ion Release DOI
Ziqi Zhou, Liyan Zhang, Muyan Qin

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

ABSTRACT Chronic wound healing is often compromised by bacterial infection, and pH changes strongly correlate with infection. Therefore, the development of dressings capable real‐time monitoring, antimicrobial activity, tissue repair crucial for effective management infected chronic wounds. This study reports a novel multifunctional composite hydrogel (GM‐C‐mBG@P) synthesized incorporating microwave‐synthesized carbon quantum dots (CQDs) polydopamine‐modified mesoporous bioactive glass nanoparticles (mBG@P) into modified gelatin methacryloyl (GelMA). The incorporated polydopamine (PDA) confers excellent photothermal properties to hydrogel, enabling activity. Under 360 nm UV excitation, fluorescence intensity CQDs in GM‐C‐mBG@P exhibits strong linear correlation pH, monitoring. Furthermore, mBG@P can gradually dissolve calcium, silicon, boron, other functional ions enhance bioactivity functionality accelerate healing. These findings suggest that has potential serve as promising dressing treatment

Language: Английский

Citations

0
A multi-purpose dressing based on resveratrol-loaded ionic liquids/gelatin methacryloyl hydrogel for enhancing diabetic wound healing DOI
Shaochen Xu, Chao Jiang,

Tao Yu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 136773 - 136773

Published: Oct. 21, 2024

Language: Английский

Citations

2
Injectable GelMA Hydrogel Microspheres with Sustained Release of Platelet‐Rich Plasma for the Treatment of Thin Endometrium DOI Open Access
Guanghui Yuan, Chenghao Yu, Xin Du

et al.

Small, Journal Year: 2024, Volume and Issue: 20(47)

Published: Aug. 29, 2024

Abstract Platelet‐rich plasma (PRP) intrauterine infusion has been demonstrated to be effective in treating thin endometrium and achieving pregnancy. However, the rapid release of growth factors limits its effectiveness clinical applications, thus, multiple infusions are often required achieve therapeutic efficacy. In this study, a GelMA hydrogel microsphere biomaterial is developed using droplet microfluidics modify delivery mode PRP thus prolong duration action. Its biocompatibility confirmed through both vivo vitro studies. Cell experiments show that PRP‐loaded microspheres significantly enhance cell proliferation, migration, angiogenesis. effects on repairing restoring fertility mice could impact triple infusions. Further mechanistic investigations reveal facilitate endometrial repair by regulating expression E2Fs, group transcription factors. This study demonstrates action, enabling functional reconstruction. design avoids repeated injections clinic, reduces number patient visits, provides new avenue for treatment endometrium.

Language: Английский

Citations

2
Alginate-based systems: advancements in drug delivery and wound healing DOI

Abdulaziz S. Al-Roujayee,

Erina Hilaj,

A. Deepak

et al.

International Journal of Polymeric Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 29

Published: July 22, 2024

Language: Английский

Citations

1
Polylysine in biomedical applications: from composites to breakthroughs DOI
Deepak Arun Annamalai,

Erina Hilaj,

Manisha Singh

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(6), P. 062002 - 062002

Published: Oct. 9, 2024

Polylysine-based composites have emerged as promising materials in biomedical applications due to their versatility, biocompatibility, and tunable properties. In drug delivery, polylysine-based furnish a novel platform for targeted controlled release of therapeutic agents. Their high loading capacity capability encapsulate diverse drugs make them ideal candidates addressing challenges such stability kinetics. Additionally, biocompatibility ensures minimal cytotoxicity, vital applications. They also hold substantial potential tissue engineering by providing scaffold with mechanical characteristics surface properties, can support cell adhesion, proliferation, differentiation. Furthermore, bioactive nature facilitates cellular interactions, promoting regeneration integration. Wound healing is another area where show promise. antimicrobial properties help prevent infections, while ability foster migration proliferation accelerates the wound procedure. Incorporation growth factors or other molecules further enhances effectiveness. biosensing applications, they serve robust substrates immobilizing biomolecules sensing elements. area-to-volume ratio excellent improve sensor sensitivity selectivity, enabling accurate detection biomarkers analytes biological samples. offer contrast agents bioimaging, aiding diagnosis monitoring diseases. Overall, represent versatile research clinical practice, holding great promise various healthcare challenges. .

Language: Английский

Citations

0