Cell Biology of Ischemia/Reperfusion Injury

International review of cell and molecular biology, Год журнала: 2012, Номер unknown, С. 229 - 317

Опубликована: Янв. 1, 2012

Язык: Английский

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The Science of Stroke: Mechanisms in Search of Treatments

Neuron, Год журнала: 2010, Номер 67(2), С. 181 - 198

Опубликована: Июль 1, 2010

Язык: Английский

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NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

Nature reviews. Immunology, Год журнала: 2010, Номер 10(3), С. 210 - 215

Опубликована: Фев. 19, 2010

Язык: Английский

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Toxicity of nanomaterials

Chemical Society Reviews, Год журнала: 2011, Номер 41(6), С. 2323 - 2343

Опубликована: Дек. 14, 2011

Nanoscience has matured significantly during the last decade as it transitioned from bench top science to applied technology. Presently, nanomaterials are used in a wide variety of commercial products such electronic components, sports equipment, sun creams and biomedical applications. There few studies long-term consequences nanoparticles on human health, but governmental agencies, including United States National Institute for Occupational Safety Health Japan's Ministry Health, have recently raised question whether seemingly innocuous materials carbon-based nanotubes should be treated with same caution afforded known carcinogens asbestos. Since increasing part everyday consumer products, manufacturing processes, medical is imperative that both workers end-users protected inhalation potentially toxic NPs. It also suggests NPs may need sequestered into so not released atmosphere product's life or recycling. Further, non-inhalation routes NP absorption, dermal injectables, must studied order understand possible effects. Fewer date addressed body can eventually eliminate prevent particle build-up tissues organs. This critical review discusses biophysicochemical properties various emphasis currently available toxicology data methodologies evaluating nanoparticle toxicity (286 references).

Язык: Английский

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Alternative Antimicrobial Approach: Nano-Antimicrobial Materials

Evidence-based Complementary and Alternative Medicine, Год журнала: 2015, Номер 2015, С. 1 - 16

Опубликована: Янв. 1, 2015

Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity mortality. Moreover, the need to develop additional bactericidal means has significantly increased due growing concern regarding multidrug-resistant strains biofilm associated infections. Consequently, attention been especially devoted new emerging nanoparticle-based materials in field chemotherapy. The present review discusses activities nanoparticles as an their mode action, nanoparticle effect on drug-resistant bacteria, risks attendant use antibacterial agents. Factors contributing performance clinical setting, unique properties, mechanism action agents discussed detail.

Язык: Английский

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Ischemia/Reperfusion

Comprehensive physiology, Год журнала: 2016, Номер unknown, С. 113 - 170

Опубликована: Дек. 6, 2016

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease, are the most common causes of debilitating disease death in westernized cultures. The extent tissue injury relates directly to blood flow reduction length ischemic period, which influence levels cellular ATP intracellular pH reduced. By impairing ATPase-dependent ion transport, ischemia mitochondrial calcium increase (calcium overload). Cell volume regulatory mechanisms also disrupted by lack ATP, can induce lysis organelle plasma membranes. Reperfusion, although required salvage oxygen-starved tissues, produces paradoxical responses that fuel production reactive oxygen species (oxygen paradox), sequestration proinflammatory immunocytes endoplasmic reticulum stress, development postischemic capillary no-reflow, amplify injury. These pathologic events culminate opening permeability transition pores a end-effector ischemia/reperfusion (I/R)-induced cell death. Emerging concepts include intestinal microbiome, fetal programming, epigenetic changes, microparticles pathogenesis I/R. overall goal this review is describe these other contribute I/R Because so many different deleterious participate I/R, it clear therapeutic approaches will be effective only when multiple processes targeted. In addition, translational significance research enhanced much wider use animal models incorporate complicating effects risk factors for cardiovascular disease. © 2017 American Physiological Society. Compr Physiol 7:113-170, 2017.

Язык: Английский

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Pathogenic mechanisms following ischemic stroke

Neurological Sciences, Год журнала: 2017, Номер 38(7), С. 1167 - 1186

Опубликована: Апрель 17, 2017

Язык: Английский

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A review on plant-based rutin extraction methods and its pharmacological activities

Journal of Ethnopharmacology, Год журнала: 2013, Номер 150(3), С. 805 - 817

Опубликована: Окт. 31, 2013

Язык: Английский

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Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

Frontiers in Neuroscience, Год журнала: 2018, Номер 12

Опубликована: Июль 10, 2018

Ferroptosis is a newly described form of regulated cell death, distinct from apoptosis, necroptosis and other forms death. induced by disruption glutathione synthesis or inhibition peroxidase 4, exacerbated iron, prevented radical scavengers such as ferrostatin-1, liproxstatin-1 endogenous vitamin E. terminates with mitochondrial dysfunction toxic lipid peroxidation. Although conclusive identification ferroptosis in vivo challenging, several salient very well established features neurodegenerative diseases are consistent ferroptosis, including peroxidation, iron dysregulation. Accordingly, interest the role neurodegeneration escalating specific evidence rapidly emerging. One aspect that has thus far received little attention antioxidant transcription factor nuclear erythroid 2-related 2 (Nrf2). This regulates hundreds genes, which many either directly indirectly involved modulating metabolism glutathione, lipids, function. potentially positions Nrf2 key deterministic component onset outcomes ferroptotic stress. The minimal direct currently available this indicates may be critical for protection against ferroptosis. In contrast, abundant demonstrates enhancing signaling potently neuroprotective models neurodegeneration, although exact mechanism achieved unclear. Further studies required to determine extent effects activation involve prevention

Язык: Английский

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Archives of Toxicology, Год журнала: 2010, Номер 84(11), С. 825 - 889

Опубликована: Авг. 16, 2010

Exposure to a variety of toxins and/or infectious agents leads disease, degeneration and death, often characterised by circumstances in which cells or tissues do not merely die cease function but may be more less entirely obliterated. It is then legitimate ask the question as whether, despite many kinds agent involved, there at least some unifying mechanisms such cell death destruction. I summarise evidence that great cases, one underlying mechanism, providing major stresses this type, entails continuing autocatalytic production (based on positive feedback mechanisms) hydroxyl radicals via Fenton chemistry involving poorly liganded iron, leading apoptosis (probably including pathways induced changes NF-κB system). While every pathway sense connected other one, highlight literature suggesting degenerative effects diseases toxicological insults converge iron dysregulation. This highlights specifically role metabolism, detailed speciation chemical toxicology, has significant implications for use chelating substances partnership with appropriate anti-oxidants) nutritional therapeutic inhibiting both progression these mainly sequelae chronic acute toxin exposure. The complexity biochemical networks, especially those behaviour feedbacks, means multiple interventions (e.g. chelators plus antioxidants) are likely prove most effective. A systems biology approaches, summarise, can predict involved optimal sites action pharmacological interventions.

Язык: Английский

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