Redox signaling at the crossroads of human health and disease

MedComm, Год журнала: 2022, Номер 3(2)

Опубликована: Март 31, 2022

Abstract Redox biology is at the core of life sciences, accompanied by close correlation redox processes with biological activities. homeostasis a prerequisite for human health, in which physiological levels nonradical reactive oxygen species (ROS) function as primary second messengers to modulate signaling orchestrating multiple sensors. However, excessive ROS accumulation, termed oxidative stress (OS), leads biomolecule damage and subsequent occurrence various diseases such type 2 diabetes, atherosclerosis, cancer. Herein, starting evolution biology, we reveal roles multifaceted modulators mediate sustain homeostasis. In addition, also emphasize detailed OS mechanisms involved initiation development several important diseases. double‐edged sword disease progression suggest two different therapeutic strategies treat redox‐relevant diseases, targeting sources redox‐related effectors manipulate will largely promote precision medicine. Therefore, comprehensive understanding networks under pathological conditions facilitate medicine benefit patients

Язык: Английский

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Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome

Nature Reviews Urology, Год журнала: 2024, Номер 21(7), С. 433 - 449

Опубликована: Фев. 7, 2024

Язык: Английский

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Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders

Antioxidants and Redox Signaling, Год журнала: 2018, Номер 31(4), С. 275 - 317

Опубликована: Дек. 26, 2018

Our current knowledge of the pathophysiology and molecular mechanisms causing psychiatric disorders is modest, but genetic susceptibility environmental factors are central to etiology these conditions. Autism, schizophrenia, bipolar disorder major depressive show gene risk overlap share symptoms metabolic comorbidities. The identification such common features may provide insights into development disorders.

Язык: Английский

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Local Melatoninergic System as the Protector of Skin Integrity

International Journal of Molecular Sciences, Год журнала: 2014, Номер 15(10), С. 17705 - 17732

Опубликована: Сен. 30, 2014

The human skin is not only a target for the protective actions of melatonin, but also site melatonin synthesis and metabolism, suggesting an important role local melatoninergic system in protection against ultraviolet radiation (UVR) induced damages. While exerts many effects on cell physiology tissue homeostasis via membrane bound receptors, strong UVR-induced damage including DNA repair/protection seen at its high (pharmocological) concentrations indicate that these are mainly mediated through receptor-independent mechanisms or perhaps activation putative nuclear receptors. destructive UVR significantly counteracted modulated by context complex intracutaneous anti-oxidative with UVR-enhanced UVR-independent metabolites. Therefore, endogenous production, together topically-applied exogenous metabolites would be expected to represent one most potent defense systems UV-induced skin. In summary, we propose can exploited therapeutically as agent survival factor anti-genotoxic properties “guardian” genome cellular integrity clinical applications pathology includes carcinogenesis aging.

Язык: Английский

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Melatonin: A review of its potential functions and effects on neurological diseases

Revue Neurologique, Год журнала: 2019, Номер 176(3), С. 148 - 165

Опубликована: Ноя. 11, 2019

Язык: Английский

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Circadian and sleep dysfunction in Alzheimer’s disease

Ageing Research Reviews, Год журнала: 2020, Номер 60, С. 101046 - 101046

Опубликована: Апрель 16, 2020

Язык: Английский

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Neurodegeneration and the Circadian Clock

Frontiers in Aging Neuroscience, Год журнала: 2017, Номер 9

Опубликована: Май 29, 2017

Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes diminished hormone release) biochemical activities antioxidant production). Circadian disturbances are among earliest symptoms these diseases, molecular mechanisms system suspected to play a pivotal, possibly causal, role their natural histories. Here, we review abnormalities observed ADs, PDs HDs, summarize evidence that clockwork directly influences course disease states. On basis this research, explore circadian-oriented interventions proposed treatments for neurological disorders.

Язык: Английский

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Circadian Rhythm and Alzheimer’s Disease

Medical Sciences, Год журнала: 2018, Номер 6(3), С. 52 - 52

Опубликована: Июнь 21, 2018

Alzheimer's disease (AD) is a neurodegenerative disorder with growing epidemiological importance characterized by significant burden. Sleep-related pathological symptomatology often accompanies AD. The etiology and pathogenesis of disrupted circadian rhythm AD share common factors, which also opens the perspective viewing them as mutually dependent process. This article focuses on bi-directional relationship between these processes, discussing pathophysiological links clinical aspects. Common mechanisms linking both processes include neuroinflammation, neurodegeneration, desynchronization. Timely recognition sleep-specific symptoms components could lead to an earlier correct diagnosis opportunity offering treatments at stage. Likewise, proper sleep hygiene related ought be one priorities in management patient population affected narrative review brings comprehensive approach clearly demonstrate underlying complexities disruption. Most data are based interventions including melatonin, but larger-scale research still scarce. Following reasoning backed evidence gained from models, novel anti-inflammatory those targeting metabolic alterations might prove useful for normalizing rhythm. By restoring it, benefits would conferred immunological, metabolic, behavioral function individual. On other hand, balanced should provide greater resilience pathogenesis.

Язык: Английский

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Circadian Rhythms, Exercise, and Cardiovascular Health

Journal of Circadian Rhythms, Год журнала: 2018, Номер 16(1)

Опубликована: Янв. 1, 2018

Human circadian rhythmicity is driven by a clock comprised of two distinct components: the central clock, located in suprachiasmatic nucleus (SCN) within hypothalamus, and peripheral clocks, almost all tissues organ systems body. Entrainment, or alignment, dependent upon time day can occur through environmental influences such as light cues physical activity exerted on skeletal muscle. Entrainment exercise has been reported to improve health reducing risk conditions cardiovascular disease (CVD), but further research still needed. The purpose this review discuss effects regulation rhythmicity, specifically with respect CVD factors – including hormonal levels, sleep/wake cycles, blood pressure, heart rate. Additionally, impact exercise-induced entrainment discussed relative hormone regulation, nocturnal pressure dipping, post-exercise hypotension, overall health.

Язык: Английский

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Hydrogen: A Novel Option in Human Disease Treatment

Oxidative Medicine and Cellular Longevity, Год журнала: 2020, Номер 2020, С. 1 - 17

Опубликована: Сен. 8, 2020

H 2 has shown anti-inflammatory and antioxidant ability in many clinical trials, its application is recommended the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed surprising finding that gas may protect lungs extrapulmonary organs from pathological stimuli NCP patients. The potential mechanisms underlying action of are not clear. regulate activity, mitochondrial energy metabolism, endoplasmic reticulum stress, immune system, cell death (apoptosis, autophagy, pyroptosis, ferroptosis, circadian clock, among others) therapeutic for systemic diseases. This paper reviews basic research applications multiorgan system diseases to establish strategies various

Язык: Английский

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