Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese DOI Creative Commons

Zhuqin Gu,

Binbin Wang, Yong‐Biao Zhang

et al.

Scientific Reports, Journal Year: 2015, Volume and Issue: 5(1)

Published: Oct. 28, 2015

Abstract Circadian disruptions may result in sleep problems, oxidative stress and an altered inflammatory response. These symptoms contribute to PD pathogenesis, despite a lack of direct experimental evidence supporting this relationship. Clock genes are essential drive maintain circadian rhythm. To elucidate the possible role PD, we investigated 132 tag variants eight clock genes. We genotyped these tags within 1,394 Chinese cases 1,342 controls using Illumina GoldenGate chips. discovered that SNPs ARNTL (rs900147, P = 3.33 × 10 −5 , OR 0.80) PER1 (rs2253820, 5.30 −6 1.31) significantly associated with risk. Moreover, positive association rs900147 variant was more robust tremor dominant (TD) ( 3.44 −4 ) than postural instability gait difficulty (PIGD) 6.06 −2 ). The rs2253820 PIGD 5.42 TD 4.2 Haplotype analysis also showed were PD. Imputation identified some which affect gene expression through altering transcription factor binding site. In summary, our findings suggest genetic polymorphisms genes, as well disruptions, pathogenesis.

Language: Английский

Redox signaling at the crossroads of human health and disease DOI
Jing Zuo, Zhe Zhang,

Maochao Luo

et al.

MedComm, Journal Year: 2022, Volume and Issue: 3(2)

Published: March 31, 2022

Abstract Redox biology is at the core of life sciences, accompanied by close correlation redox processes with biological activities. homeostasis a prerequisite for human health, in which physiological levels nonradical reactive oxygen species (ROS) function as primary second messengers to modulate signaling orchestrating multiple sensors. However, excessive ROS accumulation, termed oxidative stress (OS), leads biomolecule damage and subsequent occurrence various diseases such type 2 diabetes, atherosclerosis, cancer. Herein, starting evolution biology, we reveal roles multifaceted modulators mediate sustain homeostasis. In addition, also emphasize detailed OS mechanisms involved initiation development several important diseases. double‐edged sword disease progression suggest two different therapeutic strategies treat redox‐relevant diseases, targeting sources redox‐related effectors manipulate will largely promote precision medicine. Therefore, comprehensive understanding networks under pathological conditions facilitate medicine benefit patients

Language: Английский

Citations

79
Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome DOI
Ashu Mohammad,

Mallory A. Laboulaye,

Chen Shenhar

et al.

Nature Reviews Urology, Journal Year: 2024, Volume and Issue: 21(7), P. 433 - 449

Published: Feb. 7, 2024

Language: Английский

Citations

17
Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders DOI
Yeni Kim, Krishna C. Vadodaria, Zsolt Lenkei

et al.

Antioxidants and Redox Signaling, Journal Year: 2018, Volume and Issue: 31(4), P. 275 - 317

Published: Dec. 26, 2018

Our current knowledge of the pathophysiology and molecular mechanisms causing psychiatric disorders is modest, but genetic susceptibility environmental factors are central to etiology these conditions. Autism, schizophrenia, bipolar disorder major depressive show gene risk overlap share symptoms metabolic comorbidities. The identification such common features may provide insights into development disorders.

Language: Английский

Citations

156
Local Melatoninergic System as the Protector of Skin Integrity DOI Open Access
Andrzej Słomiński, Konrad Kleszczyński, Igor Semak

et al.

International Journal of Molecular Sciences, Journal Year: 2014, Volume and Issue: 15(10), P. 17705 - 17732

Published: Sept. 30, 2014

The human skin is not only a target for the protective actions of melatonin, but also site melatonin synthesis and metabolism, suggesting an important role local melatoninergic system in protection against ultraviolet radiation (UVR) induced damages. While exerts many effects on cell physiology tissue homeostasis via membrane bound receptors, strong UVR-induced damage including DNA repair/protection seen at its high (pharmocological) concentrations indicate that these are mainly mediated through receptor-independent mechanisms or perhaps activation putative nuclear receptors. destructive UVR significantly counteracted modulated by context complex intracutaneous anti-oxidative with UVR-enhanced UVR-independent metabolites. Therefore, endogenous production, together topically-applied exogenous metabolites would be expected to represent one most potent defense systems UV-induced skin. In summary, we propose can exploited therapeutically as agent survival factor anti-genotoxic properties “guardian” genome cellular integrity clinical applications pathology includes carcinogenesis aging.

Language: Английский

Citations

140
Melatonin: A review of its potential functions and effects on neurological diseases DOI
Mehmet Günata, Hakan Parlakpınar, Ahmet Acet

et al.

Revue Neurologique, Journal Year: 2019, Volume and Issue: 176(3), P. 148 - 165

Published: Nov. 11, 2019

Language: Английский

Citations

133
Neurodegeneration and the Circadian Clock DOI Creative Commons
Suzanne Hood, Shimon Amir

Frontiers in Aging Neuroscience, Journal Year: 2017, Volume and Issue: 9

Published: May 29, 2017

Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes diminished hormone release) biochemical activities antioxidant production). Circadian disturbances are among earliest symptoms these diseases, molecular mechanisms system suspected to play a pivotal, possibly causal, role their natural histories. Here, we review abnormalities observed ADs, PDs HDs, summarize evidence that clockwork directly influences course disease states. On basis this research, explore circadian-oriented interventions proposed treatments for neurological disorders.

Language: Английский

Citations

130
Circadian and sleep dysfunction in Alzheimer’s disease DOI
Md. Sahab Uddin, Devesh Tewari, Abdullah Al Mamun

et al.

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 60, P. 101046 - 101046

Published: April 16, 2020

Language: Английский

Citations

128
Circadian Rhythm and Alzheimer’s Disease DOI Creative Commons
Jan Homolak,

Monika Mudrovčić,

Barbara Vukić

et al.

Medical Sciences, Journal Year: 2018, Volume and Issue: 6(3), P. 52 - 52

Published: June 21, 2018

Alzheimer's disease (AD) is a neurodegenerative disorder with growing epidemiological importance characterized by significant burden. Sleep-related pathological symptomatology often accompanies AD. The etiology and pathogenesis of disrupted circadian rhythm AD share common factors, which also opens the perspective viewing them as mutually dependent process. This article focuses on bi-directional relationship between these processes, discussing pathophysiological links clinical aspects. Common mechanisms linking both processes include neuroinflammation, neurodegeneration, desynchronization. Timely recognition sleep-specific symptoms components could lead to an earlier correct diagnosis opportunity offering treatments at stage. Likewise, proper sleep hygiene related ought be one priorities in management patient population affected narrative review brings comprehensive approach clearly demonstrate underlying complexities disruption. Most data are based interventions including melatonin, but larger-scale research still scarce. Following reasoning backed evidence gained from models, novel anti-inflammatory those targeting metabolic alterations might prove useful for normalizing rhythm. By restoring it, benefits would conferred immunological, metabolic, behavioral function individual. On other hand, balanced should provide greater resilience pathogenesis.

Language: Английский

Citations

96
Circadian Rhythms, Exercise, and Cardiovascular Health DOI Creative Commons

Isabella M. Hower,

Sara A. Harper, Thomas W. Buford

et al.

Journal of Circadian Rhythms, Journal Year: 2018, Volume and Issue: 16(1)

Published: Jan. 1, 2018

Human circadian rhythmicity is driven by a clock comprised of two distinct components: the central clock, located in suprachiasmatic nucleus (SCN) within hypothalamus, and peripheral clocks, almost all tissues organ systems body. Entrainment, or alignment, dependent upon time day can occur through environmental influences such as light cues physical activity exerted on skeletal muscle. Entrainment exercise has been reported to improve health reducing risk conditions cardiovascular disease (CVD), but further research still needed. The purpose this review discuss effects regulation rhythmicity, specifically with respect CVD factors – including hormonal levels, sleep/wake cycles, blood pressure, heart rate. Additionally, impact exercise-induced entrainment discussed relative hormone regulation, nocturnal pressure dipping, post-exercise hypotension, overall health.

Language: Английский

Citations

87
Hydrogen: A Novel Option in Human Disease Treatment DOI Creative Commons
Mengling Yang, Yinmiao Dong, Qingnan He

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 17

Published: Sept. 8, 2020

H 2 has shown anti-inflammatory and antioxidant ability in many clinical trials, its application is recommended the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed surprising finding that gas may protect lungs extrapulmonary organs from pathological stimuli NCP patients. The potential mechanisms underlying action of are not clear. regulate activity, mitochondrial energy metabolism, endoplasmic reticulum stress, immune system, cell death (apoptosis, autophagy, pyroptosis, ferroptosis, circadian clock, among others) therapeutic for systemic diseases. This paper reviews basic research applications multiorgan system diseases to establish strategies various

Language: Английский

Citations

86