Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(24), С. 15814 - 15814

Опубликована: Дек. 13, 2022

Myocardial infarction (MI), a major contributor to worldwide morbidity and mortality, is caused by lack of blood flow the heart. Affected heart tissue becomes ischemic due deficiency perfusion oxygen delivery. In case sufficient cannot be timely restored, cardiac injury with necrosis occurs. The ischemic/necrotic area induces systemic inflammatory response hundreds thousands leukocytes are recruited from injured pool rapidly depleted urgent re-supply these cells needed. Myeloid generated in bone marrow (BM) spleen, released into blood, travel sites need, extravasate accumulate inside tissues accomplish various functions. this review we focus on “leukocyte supply chain” will separately evaluate different myeloid cell compartments (BM, heart) steady state after MI. Moreover, highlight local kinetics extracellular factors, chemokines danger signals involved regulation production/generation, release, transportation, uptake, activation during phase

Язык: Английский

---

The role of 14-3-3 in the progression of vascular inflammation induced by lipopolysaccharide

International Immunopharmacology, Год журнала: 2023, Номер 119, С. 110220 - 110220

Опубликована: Апрель 25, 2023

To explore the role of 14-3-3 protein and Hippo yes-associated 1 (YAP) signaling pathway in lipopolysaccharide (LPS)-induced vascular inflammation.Human umbilical vein endothelial cells (HUVECs) C57B6 mice were treated with LPS to establish cell animal models inflammation. Lentiviral transfection, Western blot, qPCR, immunofluorescence, immunohistochemistry, co-immunoprecipitation, enzyme-linked immunosorbent assays used measure inflammatory factors expression phosphorylation YAP at S127. HUVECs pretreated a inhibitor, Verteporfin, observe changes downstream inflammation.LPS induced acute chronic responses upregulated several factors. also S127 response inflammation downregulated these markers Verteporfin reduced LPS-induced effects on inflammation.In inflammation, is downregulated, which promotes by increasing Hippo/YAP nuclear translocation.

Язык: Английский

---

Triptolide attenuates irritable bowel syndrome via inhibiting ODC1

BMC Gastroenterology, Год журнала: 2023, Номер 23(1)

Опубликована: Июнь 12, 2023

Irritable bowel syndrome (IBS) is a chronic disorder of the gut-brain axis with significant morbidity. Triptolide, an active compound extracted from Tripterygium wilfordii Hook F (TwHF), has been widely used as major medicinal herb in treatment inflammatory disease. The chronic-acute combined stress (CAS) stimulation was to establish IBS rat model. model rats were then gavaged triptolide. Forced swimming, marble-burying, fecal weight and abdominal withdrawal reflex (AWR) score recorded. Pathologic changes ileal colonic tissues validated by hematoxylin eosin staining. cytokines Ornithine Decarboxylase-1 (ODC1) performed ELISA WB. Triptolide didn't have antidepressant- antianxiety- effects caused CAS, but decreased AWR score. In addition, reduced release IL-1, IL-6, TNF-α expression ODC1 ileum colon. therapeutic efficacy triptolide for induced CAS revealed this study, which may be related reduction ODC1.

Язык: Английский

---

Longitudinal Change of Serum Inter-<i>α</i>-Trypsin Inhibitor Heavy Chain H4 and its Relation with Inflammation, Disease Recurrence, and Mortality in Acute Ischemic Stroke Patients

The Tohoku Journal of Experimental Medicine, Год журнала: 2022, Номер 259(3), С. 221 - 227

Опубликована: Дек. 28, 2022

Inter-α-trypsin inhibitor heavy chain H4 (ITIH4) modulates atherosclerosis, lipid, and inflammation, which is involved in the development of acute ischemic stroke. Hence, this study aimed to investigate longitudinal change prognostic role ITIH4 In 267 patients with stroke, serum after admission (baseline), 1st day (D1), D3, D7, D30, inflammatory cytokines at baseline were detected by enzyme-linked immunosorbent assay (ELISA). Additionally, 30 controls enrollment was ELISA. reduced stroke than [median (interquartile range, IQR): 131.0 (95.5-194.3) vs. 418.6 (241.5-506.8) ng/mL] (P < 0.001). Among patients, negatively associated tumor necrosis factor-alpha (r = −0.211, P 0.001), interleukin (IL)-1β −0.164, 0.007), IL-6 −0.121, 0.049), IL-17A −0.188, 0.002). presented a decreased trend from then increased D3 D30 The 1-year, 2-year, 3-year cumulative recurrence rate 7.5%, 18.0%, 19.1%, respectively; meanwhile, death 2.2%, 7.1%, accordingly. further analysis that 0.002), D1 0.003), D7 0.001) recurrent non-recurrent patients; besides, 0.017), 0.004), but not 0.151) or 0.013), deaths survivors. Serum declines first elevates time, its reduction correlated higher risk mortality patients.

Язык: Английский

---

Lifestyle Interventions and Atherosclerotic Cardiovascular Disease Outcomes

Contemporary cardiology, Год журнала: 2024, Номер unknown, С. 167 - 200

Опубликована: Янв. 1, 2024

A healthy lifestyle across the lifespan is foundation for prevention of atherosclerotic cardiovascular disease (ASCVD). Lifestyle interventions associated with improved health and ASCVD risk reduction include dietary interventions, physical activity, adequate sleep, psychosocial health, tobacco abstinence or cessation. The majority available evidence impact on outcomes from observational studies. Results randomized controlled trials various demonstrate significant beneficial effects factors, such as lipids lipoproteins, glucose, blood pressures. totality association support following recommendations: (1) consume a high-quality pattern; (2) limit intakes saturated fatty acids replace unsaturated acids; (3) foods beverages added sugars; (4) alcohol those who do not currently drink intake to ≤1 drink/day men women choose drink; (5) participate in sufficient quantities types activity; (6) reduce excess adiposity; (7) obtain quantity quality sleep; (8) manage stressors improve psychological health; (9) abstain use.

Язык: Английский

---