Biochemical Pharmacology,
Год журнала:
2022,
Номер
203, С. 115168 - 115168
Опубликована: Июль 12, 2022
Pathological
deterioration
of
mitochondrial
function
is
increasingly
linked
with
multiple
degenerative
illnesses
as
a
mediator
wide
range
neurologic
and
age-related
chronic
diseases,
including
those
genetic
origin.
Several
these
diseases
are
rare,
typically
defined
in
the
United
States
an
illness
affecting
fewer
than
200,000
people
U.S.
population,
or
about
one
1600
individuals.
Vision
impairment
due
to
dysfunction
eye
prominent
feature
evident
numerous
primary
common
pathophysiology
many
familiar
ophthalmic
disorders,
macular
degeneration,
diabetic
retinopathy,
glaucoma
retinopathy
prematurity
—
collection
syndromes,
disorders
significant
unmet
medical
needs.
Focusing
on
metabolic
pathway
mechanisms,
possible
roles
cuproptosis
ferroptosis
retinal
dysfunction,
we
shed
light
potential
α-lipoyl-L-carnitine
treating
diseases.
α-Lipoyl-L-carnitine
bioavailable
mitochondria-targeting
lipoic
acid
prodrug
that
has
shown
protecting
against
degeneration
photoreceptor
cell
loss
indications.
Antioxidants,
Год журнала:
2023,
Номер
12(3), С. 671 - 671
Опубликована: Март 9, 2023
Iron
is
irreplaceably
required
for
animal
and
human
cells
as
it
provides
the
activity
center
a
wide
variety
of
essential
enzymes
needed
energy
production,
nucleic
acid
synthesis,
carbon
metabolism
cellular
defense.
However,
iron
toxic
when
present
in
excess
its
uptake
storage
must,
therefore,
be
tightly
regulated
to
avoid
damage.
A
growing
body
evidence
indicates
that
dysregulation
leading
quantities
free
reactive
responsible
range
otherwise
discrete
diseases.
can
promote
proliferative
diseases
such
infections
cancer
by
supplying
pathogens
or
cells.
Toxicity
from
plays
roles
pathogenesis
various
metabolic,
neurological
inflammatory
Interestingly,
common
underlying
aspect
these
conditions
availability
iron.
This
underpinning
potential
new
therapeutic
avenue.
Existing
hematologically
used
chelators
take
up
have
shown
serious
limitations
use
but
purpose-designed
development
show
promise
suppressing
microbial
pathogen
cell
growth,
also
relieving
iron-induced
toxicity
other
Hepcidin
hepcidin
agonists
are
showing
dysregulation.
Harnessing
iron-driven
oxygen
species
(ROS)
generation
with
ferroptosis
has
selective
destruction
We
review
biological
requirements,
regulation
nature
Current
results
pertaining
therapies
reviewed.
Biochemical Pharmacology,
Год журнала:
2022,
Номер
203, С. 115168 - 115168
Опубликована: Июль 12, 2022
Pathological
deterioration
of
mitochondrial
function
is
increasingly
linked
with
multiple
degenerative
illnesses
as
a
mediator
wide
range
neurologic
and
age-related
chronic
diseases,
including
those
genetic
origin.
Several
these
diseases
are
rare,
typically
defined
in
the
United
States
an
illness
affecting
fewer
than
200,000
people
U.S.
population,
or
about
one
1600
individuals.
Vision
impairment
due
to
dysfunction
eye
prominent
feature
evident
numerous
primary
common
pathophysiology
many
familiar
ophthalmic
disorders,
macular
degeneration,
diabetic
retinopathy,
glaucoma
retinopathy
prematurity
—
collection
syndromes,
disorders
significant
unmet
medical
needs.
Focusing
on
metabolic
pathway
mechanisms,
possible
roles
cuproptosis
ferroptosis
retinal
dysfunction,
we
shed
light
potential
α-lipoyl-L-carnitine
treating
diseases.
α-Lipoyl-L-carnitine
bioavailable
mitochondria-targeting
lipoic
acid
prodrug
that
has
shown
protecting
against
degeneration
photoreceptor
cell
loss
indications.
