Influence of Acute Melatonin Administration on Human Physical Performance: A Systematic Review DOI

Vinícius Silva Faria,

Leonardo Henrique Dalcheco Messias, Taciane Maria Melges Pejon

и другие.

Sports Health A Multidisciplinary Approach, Год журнала: 2023, Номер 16(1), С. 70 - 78

Опубликована: Март 5, 2023

Context: Melatonin is an ancient molecule with a wide range of functions in mammals, such as antioxidant, anti-inflammatory, and hypothermic effects among others. However, the influence acute melatonin administration on human physical performance debatable. Objective: To summarize available data from controlled trials about performance, especially respect to strength, power, speed, short- long-term continuous exercise. Data Sources: A systematic search PubMed, Web Science, Scopus, Embase, Cochrane databases up December 10, 2021, was conducted using specified keywords Boolean operators (“melatonin” AND “exercise OR circuit-based exercise plyometric tolerance test”). Study Selection: Only studies English language humans were accepted. Design: Systematic review. Level Evidence: 1. Extraction: Participants’ characteristics (sex, age, body mass, height fat percentage), dose time, outcomes trial extracted. Results: total 10 identified after screening process. Overall, did not change speed or short-term performances. relation strength results are debatable since 5 articles showed no difference, while another 2 pointed decrease performance. In terms improvement, only 1 study reported increase balance nonathletes, advantage found for athletes. Conclusion: cause any significant fact, it led reduced power performances specific tests. On other hand, seems have improved at least nonathletes. More investigations required corroborate these findings.

Язык: Английский

Dual sources of melatonin and evidence for different primary functions DOI Creative Commons
Russel J. Reíter, Ramaswamy Sharma, Dun‐Xian Tan

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 14, 2024

This article discusses data showing that mammals, including humans, have two sources of melatonin exhibit different functions. The best-known source melatonin, herein referred to as Source #1, is the pineal gland. In this organ, production circadian with maximal synthesis and release into blood cerebrospinal fluid occurring during night. Of total amount produced in we speculate less than 5% synthesized by rhythm has primary function influencing clock at level suprachiasmatic nucleus (the CSF melatonin) clockwork all peripheral organs via receptor-mediated actions. A second (Source # 2) from multiple tissues throughout body, probably being mitochondria these cells. constitutes bulk mammals concerned metabolic regulation. review emphasizes action determining re-dox homeostasis, but it other critical effects well. Extrapineal does not a released acts locally its cell origin possibly paracrine matter on adjacent factors control/influence extrapineal sites are unknown. We propose concentration cells determined subcellular redox state may be inducible under stressful conditions plant

Язык: Английский

Процитировано

25
The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging DOI Open Access
Georgeta Bocheva, Dimitar Bakalov, Petar Iliev

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5122 - 5122

Опубликована: Май 8, 2024

While primarily produced in the pineal gland, melatonin's influence goes beyond its well-known role regulating sleep, nighttime metabolism, and circadian rhythms, field of chronobiology. A plethora new data demonstrates melatonin to be a very powerful molecule, being potent ROS/RNS scavenger with anti-inflammatory, immunoregulatory, oncostatic properties. Melatonin metabolites exert multiple beneficial effects cutaneous systemic aging. This review is focused on neuroprotective during has an anti-aging capacity, retarding rate healthy brain aging development age-related neurodegenerative diseases, such as Alzheimer's disease, Parkinson's Huntington's sclerosis, amyotrophic lateral etc. Melatonin, well metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) N1-acetyl-5-methoxykynuramine (AMK), can reduce oxidative damage by shielding mitochondria from dysfunction process. could also implicated treatment conditions, modifying their characteristic low-grade neuroinflammation. It either prevent initiation inflammatory responses or attenuate ongoing inflammation. Drawing current knowledge, this discusses potential benefits supplementation preventing managing cognitive impairment diseases.

Язык: Английский

Процитировано

17
Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment DOI Creative Commons
Russel J. Reíter, Ramaswamy Sharma, Walter Manucha

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102480 - 102480

Опубликована: Сен. 3, 2024

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient oxidative phosphorylation (OXPHOS) and elevated electron leakage from the transport chain (ETC) promoting increased intramitochondrial generation of damaging reactive oxygen nitrogen species (ROS RNS). The associated progressive accumulation molecular damage causes an increasingly rapid decline in mitochondrial physiology contributing to aging. Melatonin, a multifunctional free radical scavenger indirect antioxidant, is synthesized matrix neurons. Melatonin reduces ETC elevates ATP production; it also detoxifies ROS/RNS via SIRT3/FOXO pathway upregulates activities superoxide dismutase 2 glutathione peroxidase. influences glucose processing by In neurogenerative diseases, often adopt Warburg-type metabolism which excludes pyruvate mitochondria causing reduced acetyl coenzyme A production. Acetyl supports citric acid cycle OXPHOS. Additionally, required co-substrate for arylalkylamine-N-acetyl transferase, rate limits melatonin synthesis; therefore, production diminished cells that experience making more vulnerable stress. Moreover, endogenously produced diminishes during aging, further increasing components. More normal preserved aging with supplementation.

Язык: Английский

Процитировано

14
Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin DOI Creative Commons

Feng-Wen Niu,

Mingdong Liu,

Kai Yao

и другие.

Environment International, Год журнала: 2025, Номер 197, С. 109346 - 109346

Опубликована: Фев. 23, 2025

Arsenic (As) is an environmental metalloid. Previous studies have demonstrated that As exposure resulted in decline of sperm quality. This study aimed to investigate the impact on blood-testis barrier (BTB) a mouse model. Four-week-old male mice were exposed NaAsO2 (1 or 15 mg/L) for 6 weeks. Our results found disrupted BTB and reduced counts adult mice. activated integrated stress response (ISR) downregulated junction protein testes Sertoli cells. Ribosome profiling sequencing (Ribo-seq) Ribosome-nascent chain complex-bound mRNA qPCR (RNC-qPCR) showed translational efficiency N-cadherin ZO-1, two key proteins, was NaAsO2-treated Mechanistically, SIRT3 via proteasomal degradation, thereby resulting mitochondrial dysfunction excess ROS (mtROS) generation Melatonin alleviated NaAsO2-induced mtROS upregulation reducing SOD2 acetylation Moreover, melatonin antagonized ISR, proteins downregulation function impairment Accordingly, attenuated NaAsO2-evoked disruption count reduction These suggest dysfunction-associated inhibition involved As-mediated quality decline.

Язык: Английский

Процитировано

1
Mitochondrial Quality and Quantity Control: Mitophagy Is a Potential Therapeutic Target for Ischemic Stroke DOI

Meiying Song,

Yuan Zhou, Xiang Fan

и другие.

Molecular Neurobiology, Год журнала: 2022, Номер 59(5), С. 3110 - 3123

Опубликована: Март 9, 2022

Язык: Английский

Процитировано

32
Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System DOI Creative Commons
Kenneth Maiese

Biomolecules, Год журнала: 2023, Номер 13(5), С. 816 - 816

Опубликована: Май 11, 2023

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning knowledge that disease intimately tied to neurodegenerative disorders, affecting both central and peripheral nervous systems well leading dementia, seventh cause of death. New innovative therapeutic strategies address metabolism, apoptosis, autophagy, pyroptosis, mechanistic target rapamycin (mTOR), AMP activated protein kinase (AMPK), growth factor signaling with erythropoietin (EPO), risk factors apolipoprotein E (APOE-ε4) gene coronavirus 2019 (COVID-19) can offer valuable insights for clinical care treatment disorders impacted by disease. Critical insight into modulation these complex pathways are required since mTOR pathways, AMPK activation, improve memory retention in Alzheimer's (AD) DM, promote healthy aging, facilitate clearance β-amyloid (Aß) tau brain, control inflammation, but also may lead cognitive loss long-COVID syndrome through mechanisms include oxidative stress, mitochondrial cytokine release, APOE-ε4 if autophagy other programmed cell death left unchecked.

Язык: Английский

Процитировано

21
Function of intramitochondrial melatonin and its association with Warburg metabolism DOI Creative Commons

R.J. Reiter,

Ramaswamy Sharma, Yidong Bai

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111754 - 111754

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease DOI
Kenneth Maiese

Current Neurovascular Research, Год журнала: 2023, Номер 20(3), С. 314 - 333

Опубликована: Июль 25, 2023

Disorders of metabolism affect multiple systems throughout the body but may have greatest impact on both central and peripheral nervous systems. Currently available treatments behavior changes for disorders that include diabetes mellitus (DM) system diseases are limited cannot reverse disease burden. Greater access to healthcare a longer lifespan led an increased prevalence metabolic neurodegenerative disorders. In light these challenges, innovative studies into underlying pathways offer new treatment perspectives Alzheimer's Disease, Parkinson's Huntington's Disease. Metabolic intimately tied can lead debilitating outcomes, such as multi-nervous disease, susceptibility viral pathogens, long-term cognitive disability. Novel strategies robustly address involve careful consideration cellular metabolism, programmed cell death pathways, mechanistic target rapamycin (mTOR) its associated mTOR Complex 1 (mTORC1), 2 (mTORC2), AMP-activated protein kinase (AMPK), growth factor signaling, risk factors apolipoprotein E (APOE-ε4) gene. Yet, complex necessitate comprehensive understanding achieve clinical outcomes susceptibility, onset, progression.

Язык: Английский

Процитировано

15
Role of Melatonin in Viral, Bacterial and Parasitic Infections DOI Creative Commons
Georges J. M. Maestroni

Biomolecules, Год журнала: 2024, Номер 14(3), С. 356 - 356

Опубликована: Март 16, 2024

In all mammals, the circulating pool of MLTs is synthesized in pineal gland during night’s darkness hours. Its main function synchronizing organism photoperiod. contrast, extra-pineal MLT peripheral organs, does not follow any circadian rhythm or circulate, and plays a detoxifying cytoprotective role. Circulating may stimulate both innate acquired immune responses through its action by activating high-affinity receptors on immunocompetent cells. Extra-pineal have antioxidant anti-inflammatory effects that dampen response. These two seemingly divergent roles be considered to sides same coin. fact, integration functions might generate balanced effective response against microbial pathogens. The studies described this review investigated exogenous various models infectious diseases using extremely different doses treatment schedules. None them evaluated possibility integrating non-circadian effect with immunoenhancing MLT. As consequence, spite fact most agree has beneficial infections, it seems difficult draw definite conclusion about possible therapeutic use.

Язык: Английский

Процитировано

6
The Sentient Cell DOI
Arthur S. Reber, František Baluška, William B. Miller

и другие.

Oxford University Press eBooks, Год журнала: 2023, Номер unknown

Опубликована: Окт. 5, 2023

Abstract This volume is the natural follow-up to Arthur Reber’s 2019 book, The First Minds: Caterpillars, ‘Karyotes, and Consciousness (TFM). In that earlier work, Cellular Basis of (CBC) theory was developed based on a number efforts published in variety journals between 1997 as well talks, colloquia, presentations at conferences. core proposition TFM life mind are co-terminous. All organisms, all species extant extinct, sentient. have an existentially secure consciousness—without which they would been evolutionary dead-ends, unable survive chaotic, dangerous environment first appeared. And, importantly, forms sentience, cognitive functioning right up including those expressed by humans, evolved from original expression consciousness birth prokaryotes. unicellular widely accepted, foundational principle biological social sciences. CBC simply applies same sentience.

Язык: Английский

Процитировано

13