Опубликована: Янв. 1, 2024
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11
Опубликована: Авг. 4, 2023
Malignant tumors represent a major threat to global health and the search for effective treatments is imperative. While various exist, including surgery, radiotherapy, chemotherapy, immunotherapy combination therapies, there remains need develop therapies that target regulated cell death pathways eliminate cancer cells while preserving normal cells. Alkaliptosis, pH-dependent process triggered by small molecular compound JTC801, has been identified as novel approach malignant tumor treatment, particularly in pancreatic cancer. Two signaling pathways, NF-κB-CA9 pathway ATP6V0D1-STAT3 pathway, contribute induction of alkaliptosis. This review summarizes recent developments our understanding alkaliptosis signals, mechanisms, modulation, explores its context-dependent effects on drug resistance, inflammation, immunity. By providing deeper heterogeneity plasticity this information holds promise informing design more anti-tumor therapies.
Язык: Английский
Процитировано
31
Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16
Опубликована: Апрель 23, 2024
The expanding geriatric population, whose predisposition toward disabling morbidities and age-related diseases (ARD) is well-documented, has become a paramount social issue, exerting an onerous burden on both the healthcare industry wider society. ARD manifest as progressive deterioration of bodily tissues organs, eventually resulting in failure these vital components. At present, no efficacious measures exist to hinder onset ARD. Copper, essential trace element, involved wide range physiological processes across different cell types. In recent research, novel variant copper-dependent death, termed cuproptosis, been identified. This mode cellular demise stands apart from previously recognized types death. Cuproptosis occurs when copper binds with acyl-CoA synthetase tricarboxylic acid (TCA) cycle, protein aggregation toxicity stress, ultimately leading this paper, we provide concise overview current understanding concerning metabolism copper, copper-related diseases, hallmarks toxicity, mechanisms that regulate toxicity. Additionally, discuss implications cuproptosis mutations development ARD, well potential for targeting treatment
Язык: Английский
Процитировано
10
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Апрель 1, 2025
Abstract Ferroptosis represents an emerging, iron-dependent form of cell death driven by lipid peroxidation. In recent years, it has garnered significant attention in the realm cancer immunotherapy, particularly studies involving immune checkpoint inhibitors. This not only enhances our comprehension tumor microenvironment but is also considered a promising therapeutic strategy to address resistance, investigate activation mechanisms, and facilitate development vaccines. The combination immunotherapy with ferroptosis provides innovative targets fresh perspectives for advancing treatment. Nevertheless, cells appear possess wider array evasion strategies compared CD8 + T cells, which have been conclusively shown be more vulnerable ferroptosis. Furthermore, TME can create favorable environment survival invasion. Under this premise, both inducing inhibiting will impact antitumor immunity some extent, even make final result run counter purpose. paper systematically elucidates dual-edged sword role process briefly outlining complexity within TME. It explores potential side effects associated ferroptosis-inducing therapies critically considers combined application ferroptosis-based ICIs. highlights current challenges faced approach points out future directions development.
Язык: Английский
Процитировано
2
Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(5)
Опубликована: Май 4, 2024
Abstract Purpose Acute myeloid leukemia (AML) is a refractory hematologic malignancy that poses serious threat to human health. Exploring alternative therapeutic strategies capable of inducing modes cell death, such as ferroptosis, holds great promise viable and effective intervention. Methods We analyzed online database data collected clinical samples verify the expression function BMAL1 in AML. conducted experiments on AML proliferation, cycle, chemotherapy resistance by overexpressing/knocking down using assays MDA detection BODIPY 581/591 C11 staining. validated transcriptional regulation HMGB1 through ChIP assay, luciferase RNA level detection, western blotting. Finally, we confirmed results our at animal level. Results up-regulation an observed phenomenon patients. Furthermore, there existed strong correlation between elevated levels inferior prognosis individuals with found knocking inhibited growth blocking cycle. Conversely, overexpressing promoted proliferation. Moreover, research revealed ferroptosis cells BMAL1-HMGB1-GPX4 pathway. can enhance efficacy certain first-line cancer drugs, including venetoclax, dasatinib, sorafenib. Conclusion Our suggest plays crucial regulatory role drug resistance, ferroptosis. could be potential important target for
Язык: Английский
Процитировано
5
International Immunopharmacology, Год журнала: 2024, Номер 140, С. 112886 - 112886
Опубликована: Авг. 10, 2024
High mobility group box proterin-1 (HMGB-1) is a multifunctional protein that can be released by various programmed cell deaths (PCDs), such as necroptosis and ferroptosis. PCDs play critical role in the pathogenesis of systemic lupus erythematosus (SLE). However, HMGB-1 process SLE remains unclear. This study aims to demonstrate potential diagnosing serum We found levels HMGB-1, receptor-interacting kinase 3 (RIPK3) /mixed lineage domain-like (MLKL) related with necroptosis, metabolites associated ferroptosis were significantly upregulated patients compared HC individuals. These positively correlated disease activity. Additionally, level showed strong positive RIPK3/MLKL metabolites. Moreover, was renal involvement high-antinuclear antibodies (ANA) titer. After interferon γ (IFN-γ) treatment vitro, markers activated HMGB1 both HEK293 HK2 cells. Clinically, considered significant independent risk factor binary logistic assay. Notably, exhibited outstanding diagnostic ability for area under curve (AUC) receiver operating characteristic (ROC) analysis. Taken together, our indicates promising biomarker diagnosis monitoring SLE.
Язык: Английский
Процитировано
3
Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111607 - 111607
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 4, 2025
Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease with multiple tissue damage. However, the pathology remains elusive, effective treatments are lacking. Multiple types of programmed cell death (PCD) implicated in SLE progression have recently been identified. Although ferroptosis, an iron-dependent form death, has numerous pathophysiological features similar to those SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders concentration damage associated-molecular patterns (DAMPs), only few reports demonstrated that ferroptosis involved role pathogenesis continues be neglected. Therefore, this review elucidates potential intricate relationship between provide reliable theoretical basis for further research on SLE.
Язык: Английский
Процитировано
0
Reproductive Sciences, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Abstract Introduction Trophoblast cells undergo ferroptosis in pregnancy-related diseases. HMGB1 participates pathological ferroptosis. However, whether lipopolysaccharide (LPS) -mediated expression induces the of trophoblast and further spontaneous abortion (SA) remains unknown. Methods ACSL4 were measured villous tissues from 20 women with SA elective abortion. Human HTR-8/SVneo treated LPS to establish an vitro model. The hallmarks including MDA, GSH, Fe 2+ ROS detected using indicated assay kits. Results levels significantly higher than those normal control group. interacts stabilizes promote cells. Conversely, and/or inhibition attenuated LPS-induced Conclusions An HMGB1/ACSL4 axis is engaged cells, may be targeted design treatments preventing SA.
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер 176, С. 214339 - 214339
Опубликована: Май 6, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2023, Номер 12(17), С. 2176 - 2176
Опубликована: Авг. 30, 2023
(1) Background: Breast cancer is a frequent heterogeneous disorder diagnosed in women and causes high number of mortality among this population due to rapid metastasis disease recurrence. Ferroptosis can inhibit breast cell growth, improve the sensitivity chemotherapy radiotherapy, distant metastases, potentially impacting tumor microenvironment. (2) Methods: Through data mining, ferroptosis/extracellular matrix remodeling literature text-mining results were integrated into transcriptome cohort, taking account patients with relapse-free survival (DRFS) under adjuvant therapy (anthracyclin + taxanes) validation an independent METABRIC along MDA-MB-231 HCC338 functional experiments ferroptosis activations (GSE173905). (3) Results: Ferroptosis/extracellular identified 910 associated genes. Univariate Cox analyses focused on (GSE25066) selected 252 individual significant genes, which 170 found have adverse expression. Functional enrichment these genes predicted basal signatures. text-mining, some ferroptosis-significant adverse-selected shared citations domain ECM remodeling, such as TNF, IL6, SET, CDKN2A, EGFR, HMGB1, KRAS, MET, LCN2, HIF1A, TLR4. A molecular score based expression eleven was predictive worst prognosis at univariate level: subtype, short DRFS, high-grade values 3 4, estrogen progesterone receptor negative nodal stages 2 3. This eleven-gene signature validated regulated by inductors (erastin RSL3) triple-negative cellular model MDA-MB-231. (4) Conclusions: The crosstalk between remodeling-ferroptosis functionalities allowed for defining score, has been characterized parameter patients. gene be erastin/RSL3 activators. could promising evaluate ECM-related impact target therapies cancer.
Язык: Английский
Процитировано
5