Immunogenic cell death signatures derived from on-treatment tumor specimens for predicting immune checkpoint blockade therapy response and prognosis in metastatic melanoma DOI Creative Commons
Huancheng Zeng,

Qiongzhi Jiang,

Rendong Zhang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 17, 2024

Abstract Melanoma is a highly malignant form of skin cancer that typically originates from abnormal melanocytes. Despite significant advances in treating metastatic melanoma with immune checkpoint blockade (ICB) therapy, substantial number patients do not respond to this treatment and face risks recurrence metastasis. This study collected data multiple datasets, including cohorts Riaz et al., Gide MGH, Abril-Rodriguez focusing on on-treatment samples during ICB therapy. We used the single-sample gene set enrichment analysis (ssGSEA) method calculate immunogenic cell death scores (ICDS) employed an elastic network algorithm construct model predicting efficacy. By analyzing 18 ICD signatures, we identified 9 key signatures effectively predict response for specimens. Results showed high had significantly higher rates therapy compared those low scores. ROC demonstrated AUC values both training validation sets were around 0.8, indicating good predictive performance. Additionally, survival revealed longer progression-free (PFS) overall (OS). identify related melanoma. These features can only efficacy but also provide references clinical decision-making. The results indicate plays important role immunotherapy expressing more accurately prognosis specimens, thus providing basis personalized treatment.

Язык: Английский

Emerging role of immunogenic cell death in cancer immunotherapy DOI Creative Commons

Kei‐ichiro Arimoto,

Sayuri Miyauchi,

Mengdan Liu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to immunotherapy is suboptimal, primarily attributed low immunogenicity in certain types of malignant tumors. Immunogenic cell death (ICD) represents form regulated (RCD) capable enhancing tumor and activating tumor-specific innate adaptive responses immunocompetent hosts. Therefore, gaining deeper understanding ICD evolution crucial developing more therapeutic strategies. This review focuses exclusively on both historical recent discoveries related modes their mechanistic insights, particularly within context immunotherapy. Our findings are also highlighted, revealing mode induction facilitated by atypical interferon (IFN)-stimulated genes (ISGs), including polo-like kinase 2 ( PLK2 ), during hyperactive type I IFN signaling. The concludes discussing potential ICD, with special attention relevance preclinical settings field

Язык: Английский

Процитировано

13
Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases DOI
Zhibo Yang,

Ridong Feng,

Zhao Hai

и другие.

APOPTOSIS, Год журнала: 2024, Номер 29(9-10), С. 1330 - 1360

Опубликована: Июль 16, 2024

Язык: Английский

Процитировано

12
Targeting paraptosis in cancer: opportunities and challenges DOI Open Access
Fangquan Chen, Hu Tang,

Xiutao Cai

и другие.

Cancer Gene Therapy, Год журнала: 2024, Номер 31(3), С. 349 - 363

Опубликована: Янв. 4, 2024

Язык: Английский

Процитировано

11
Disulfidptosis: A new type of cell death DOI Creative Commons
Fei Xiao, Huili Li, Bei Yang

и другие.

APOPTOSIS, Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Abstract Disulfidptosis is a novel form of cell death that distinguishable from established programmed pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis. This process characterized by the rapid depletion nicotinamide adenine dinucleotide phosphate (NADPH) in cells high expression solute carrier family 7 member 11 (SLC7A11) during glucose starvation, resulting abnormal cystine accumulation, which subsequently induces andabnormal disulfide bond formation actin cytoskeleton proteins, culminating network collapse disulfidptosis. review aimed to summarize underlying mechanisms, influencing factors, comparisons with traditional pathways, associations related diseases, application prospects, future research directions

Язык: Английский

Процитировано

9
Alkaliptosis induction counteracts paclitaxel‐resistant ovarian cancer cells via ATP6V0D1‐mediated ABCB1 inhibition DOI
Fangquan Chen, Junhao Lin, Rui Kang

и другие.

Molecular Carcinogenesis, Год журнала: 2024, Номер 63(8), С. 1515 - 1527

Опубликована: Май 15, 2024

Abstract Paclitaxel serves as the cornerstone chemotherapy for ovarian cancer, yet its prolonged administration frequently culminates in drug resistance, presenting a substantial challenge. Here we reported that inducing alkaliptosis, rather than apoptosis or ferroptosis, effectively overcomes paclitaxel resistance. Mechanistically, ATPase H + transporting V0 subunit D1 (ATP6V0D1), key regulator of plays pivotal role by mediating downregulation ATP‐binding cassette subfamily B member 1 (ABCB1), multidrug resistance protein. Both ATP6V0D1 overexpression through gene transfection and pharmacological enhancement protein stability using JTC801 inhibit ABCB1 upregulation, resulting growth inhibition drug‐resistant cells. Additionally, increasing intracellular pH to alkaline (pH 8.5) via sodium hydroxide application suppresses expression, whereas reducing acidic conditions 6.5) with hydrochloric acid amplifies expression Collectively, these results indicate potentially effective therapeutic strategy targeting paclitaxel‐resistant cancer ATP6V0D1‐dependent alkaliptosis.

Язык: Английский

Процитировано

8
N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential DOI Creative Commons
Qihui Wu, Xiaodan Fu,

Guoqian Liu

и другие.

Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 29, 2025

N7-methylguanosine (m7G) is an important RNA modification involved in epigenetic regulation that commonly observed both prokaryotic and eukaryotic organisms. Their influence on the synthesis processing of messenger RNA, ribosomal transfer allows m7G modifications to affect diverse cellular, physiological, pathological processes. are pivotal human diseases, particularly cancer progression. On one hand, modification-associated modulate tumour progression malignant biological characteristics, including sustained proliferation signalling, resistance cell death, activation invasion metastasis, reprogramming energy metabolism, genome instability, immune evasion. This suggests they may be novel therapeutic targets for treatment. other aberrant expression molecules linked clinicopathological staging, lymph node unfavourable prognoses patients with cancer, indicating their potential as biomarkers. review consolidates discovery, identification, detection methodologies, functional roles modification, analysing mechanisms by which contribute development, exploring clinical applications diagnostics therapy, thereby providing innovative strategies identification targeted

Язык: Английский

Процитировано

1
Multiple programmed cell death patterns predict the prognosis and drug sensitivity in gastric cancer DOI Creative Commons

Qiying Song,

Shihe Liu, Di Wu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 4, 2025

Background Gastric cancer (GC) is a malignant tumor with poor prognosis. The diverse patterns of programmed cell death (PCD) are significantly associated the pathogenesis and progression GC, it has potential to serve as prognostic drug sensitivity indicators for GC. Method sequencing data clinical characteristics GC patients were downloaded from Cancer Genome Atlas GEO databases. LASSO cox regression method was used screen feature genes develop PCD score (PCDS). Immune infiltration, immune checkpoint expression, Tumor Dysfunction Exclusion (TIDE) algorithm analysis explore immunotherapy response. By integrating PCDS characteristics, we constructed validated nomogram that demonstrated robust predictive performance. Results We screened nine PCD-related (SERPINE1, PLPPR4, CDO1, MID2, NOX4, DYNC1I1, PDK4, MYB, TUBB2A) create PCDS. found high experienced poorer prognoses, identified an independent factor. Furthermore, there significant difference in profile between low groups. Additionally, indicated may exhibit resistance standard adjuvant chemotherapy regimens; however, they benefit FDA-approved Dasatinib. Conclusion Overall, confirmed risk factor valuable predictor response patients, which provides new evidence application

Язык: Английский

Процитировано

0
A Predictive Model for Prognosis and Therapeutic Response in early-stage Hepatocellular Carcinoma: emphasis on program cell death genes DOI Creative Commons
Chang Liu, Xiaojun Jin, Yuan An

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract The principal cause of treatment ineffectiveness inhepatocellular carcinoma (HCC) patients stems from post-surgery stagnation and resistance. A comprehensive predictive model for the progression drug response HCC remains elusive. Various programmed cell death (PCD) patterns significantly influence tumor advancement, offering potential as prognostic sensitivity indicators postsurgery HCC. analysis in this study utilized integrated data 12 different types PCD, multi-omics TCGA-HCC other cohorts International Cancer Genome Consortium (ICGC), well clinical information patients. PCD score was calculated using a four-gene signature determined through cox regression analysis. Validation independent datasets revealed that with high scores had poorer prognoses post-surgery. Furthermore, an unsupervised clustering identified two distinct molecular subtypes unique biological processes. nomogram exhibiting accuracy developed by integrating characteristics. association between death, immune checkpoint genes key components microenvironment. established. Patients displaying elevated CDI levels demonstrated resistance to traditional adjuvant chemotherapy inhibitor therapies. Additionally, oncogenic function four inpatient cohort. novel scoring methodology devised examination linked diverse subtypes, providing valuable insights into prognosis responsiveness Early-stage may potentially derive therapeutic benefits therapy directed at death.

Язык: Английский

Процитировано

0
Assessing the role of programmed cell death signatures and related gene TOP2A in progression and prognostic prediction of clear cell renal cell carcinoma DOI Creative Commons
Qingshui Wang, Jiamin Liu,

Ruiqiong Li

и другие.

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Май 10, 2024

Abstract Kidney Clear Cell Carcinoma (KIRC), the predominant form of kidney cancer, exhibits a diverse therapeutic response to Immune Checkpoint Inhibitors (ICIs), highlighting need for predictive models ICI efficacy. Our study has constructed prognostic model based on 13 types Programmed Death (PCD), which are intertwined with tumor progression and immune microenvironment. Validated by analyses comprehensive datasets, this identifies seven key PCD genes that delineate two subtypes distinct profiles sensitivities anti-PD-1 therapy. The high-PCD group demonstrates more immune-suppressive environment, while low-PCD shows better responses PD-1 treatment. In particular, TOP2A emerged as crucial, its inhibition markedly reducing KIRC cell growth mobility. These findings underscore relevance PCDs in predicting outcomes immunotherapy response, implications enhancing clinical decision-making.

Язык: Английский

Процитировано

4
Intracellular metal ion-based chemistry for programmed cell death DOI
Y You, Zhongying Guo, Tyler Wolter

и другие.

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular intracellular signaling, and electron transfer. It is crucial to maintain ion homeostasis which achieved by the subtle balance of storage release intracellularly along with influx efflux at interface cell membrane. Dysregulation has been identified as a key mechanism triggering programmed death (PCD). Despite importance initiating PCD, molecular mechanisms within these processes are infrequently discussed. An in-depth understanding review role PCD may better uncover novel tools for cancer diagnosis therapy. Specifically, calcium (Ca

Язык: Английский

Процитировано

0