“Cupuaçu” (Theobroma grandiflorum): A brief review on chemical and technological potential of this Amazonian fruit
Food Chemistry Advances,
Год журнала:
2024,
Номер
5, С. 100747 - 100747
Опубликована: Июнь 15, 2024
Язык: Английский
l-Theanine: From Tea Leaf to Trending Supplement – Does the Science Match the Hype for Brain Health and Relaxation?
Nutrition Research,
Год журнала:
2025,
Номер
134, С. 39 - 48
Опубликована: Янв. 2, 2025
l-Theanine
is
a
unique
non-protein
amino
acid
found
abundantly
in
tea
leaves.
Interest
its
potential
use
as
dietary
supplement
has
surged
recently,
especially
claims
related
to
promoting
relaxation
and
cognitive
enhancement.
This
review
surveys
the
chemistry,
metabolism,
purported
biological
activities
of
l-theanine.
It
well
absorbed
from
intestine
can
cross
blood-brain
barrier.
Some
studies
suggest
l-theanine
may
increase
alpha
waves
brain
associated
with
selective
attention,
reduce
stress
anxiety,
improve
sleep
quality,
though
findings
are
often
inconsistent.
Potential
neuroprotective
anti-seizure
effects
have
also
been
reported
animal
models.
When
combined
caffeine,
performance,
alertness
focus.
However,
evidence
supporting
many
health
remains
limited,
lack
rigorous
human
clinical
trials.
While
exhibits
good
safety
profile
based
on
toxicology
studies,
caution
warranted
regarding
benefits,
until
stronger
scientific
substantiation
emerges.
Overall,
mechanisms
action
therapeutic
require
further
investigation,
given
current
interest
increasing
popularity
this
nutraceutical
marketed
for
relaxation.
In
absence
well-designed
carefully
controlled
trials,
we
would
urge
supplements
at
pharmacologic
doses
by
wider
population,
believe
that
science
does
not
yet
match
hype
behind
trending
Язык: Английский
About the influence of the natural anthocyanin delphinidin on the lifespan of Drosophila melanogaster
Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences,
Год журнала:
2025,
Номер
0(9), С. 92 - 97
Опубликована: Янв. 10, 2025
Anthocyanins
are
vividly
colored
pigments
that
appear
pink,
red,
blue,
or
violet
and
dissolved
in
the
vacuolar
sap
of
epidermal
tissues
flowers,
fruits,
leaves,
stems.
Delphinidin
is
one
most
common
anthocyanins
with
heroprotective
potential.
In
this
study,
we
examined
effect
delphinidin
on
lifespan
both
male
female
Drosophila
melanogaster.
Our
results
showed
concentration
10
µM
causes
a
statistically
significant
decrease
median
melanogaster
by
5%
an
increase
females
4
%.
However,
mechanism
action
organism
still
understudied
limits
our
understanding
its
properties.
context,
studying
effects
stress
resistance,
viability
indicators,
expression
levels
aging-related
genes
appears
to
be
promising
direction.
Such
studies
would
discover
mechanisms
heroprotection
aging,
as
well
answer
question
how
natural
like
can
used
improve
human
health
enlarge
lifespan.
Язык: Английский
Dietary Polyphenols as Geroprotective Compounds: From Blue Zones to Hallmarks of Ageing
Ageing Research Reviews,
Год журнала:
2025,
Номер
unknown, С. 102733 - 102733
Опубликована: Март 1, 2025
Язык: Английский
Toward a rational therapeutic for elastin related disease: key considerations for elastin based regenerative medicine strategies
Matrix Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Antitumor properties of colored native potatoes (Solanum tuberosum ssp. tuberosum) from southern Chile
Food Bioscience,
Год журнала:
2024,
Номер
61, С. 104969 - 104969
Опубликована: Авг. 23, 2024
Язык: Английский
Development of novel flavonoid senolytics through phenotypic drug screening and drug design
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 27, 2024
Abstract
Accumulation
of
senescent
cells
drives
aging
and
age-related
diseases.
Senolytics,
which
selectively
kill
cells,
offer
a
promising
approach
for
treating
many
Using
cell-based
phenotypic
drug
discovery
that
combines
screening
design,
we
developed
two
novel
flavonoid
senolytics,
SR29384
SR31133,
derived
from
the
senolytic
fisetin.
These
compounds
demonstrated
enhanced
activities,
effectively
eliminating
multiple
cell
types,
reducing
tissue
senescence
in
vivo
,
extending
healthspan
mouse
model
accelerated
aging.
Mechanistic
studies
utilizing
RNA-Seq,
machine
learning,
network
pharmacology,
computational
simulation
suggest
these
senolytics
target
PARP1,
BCL-xL,
CDK2
to
induce
selective
death.
This
phenotype-based
coupled
with
mechanistic
insights,
represents
key
advancement
developing
next-generation
senolyticss
potential
clinical
applications
Язык: Английский