Development of novel flavonoid senolytics through phenotypic drug screening and drug design DOI Creative Commons
Lei Zhang, Rahagir Salekeen,

Carolina Soto-Palma

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Accumulation of senescent cells drives aging and age-related diseases. Senolytics, which selectively kill cells, offer a promising approach for treating many Using cell-based phenotypic drug discovery that combines screening design, we developed two novel flavonoid senolytics, SR29384 SR31133, derived from the senolytic fisetin. These compounds demonstrated enhanced activities, effectively eliminating multiple cell types, reducing tissue senescence in vivo , extending healthspan mouse model accelerated aging. Mechanistic studies utilizing RNA-Seq, machine learning, network pharmacology, computational simulation suggest these senolytics target PARP1, BCL-xL, CDK2 to induce selective death. This phenotype-based coupled with mechanistic insights, represents key advancement developing next-generation senolyticss potential clinical applications

Language: Английский

“Cupuaçu” (Theobroma grandiflorum): A brief review on chemical and technological potential of this Amazonian fruit DOI Creative Commons
Jaqueline de Araújo Bezerra, Renilto Frota Corrêa, Edgar Aparecido Sanches

et al.

Food Chemistry Advances, Journal Year: 2024, Volume and Issue: 5, P. 100747 - 100747

Published: June 15, 2024

Language: Английский

Citations

4
l-Theanine: From Tea Leaf to Trending Supplement – Does the Science Match the Hype for Brain Health and Relaxation? DOI Creative Commons
Roderick H. Dashwood, Francesco Visioli

Nutrition Research, Journal Year: 2025, Volume and Issue: 134, P. 39 - 48

Published: Jan. 2, 2025

l-Theanine is a unique non-protein amino acid found abundantly in tea leaves. Interest its potential use as dietary supplement has surged recently, especially claims related to promoting relaxation and cognitive enhancement. This review surveys the chemistry, metabolism, purported biological activities of l-theanine. It well absorbed from intestine can cross blood-brain barrier. Some studies suggest l-theanine may increase alpha waves brain associated with selective attention, reduce stress anxiety, improve sleep quality, though findings are often inconsistent. Potential neuroprotective anti-seizure effects have also been reported animal models. When combined caffeine, performance, alertness focus. However, evidence supporting many health remains limited, lack rigorous human clinical trials. While exhibits good safety profile based on toxicology studies, caution warranted regarding benefits, until stronger scientific substantiation emerges. Overall, mechanisms action therapeutic require further investigation, given current interest increasing popularity this nutraceutical marketed for relaxation. In absence well-designed carefully controlled trials, we would urge supplements at pharmacologic doses by wider population, believe that science does not yet match hype behind trending

Language: Английский

Citations

0
About the influence of the natural anthocyanin delphinidin on the lifespan of Drosophila melanogaster DOI
E. Platonova, Denis Golubev,

S. A. Patov

et al.

Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences, Journal Year: 2025, Volume and Issue: 0(9), P. 92 - 97

Published: Jan. 10, 2025

Anthocyanins are vividly colored pigments that appear pink, red, blue, or violet and dissolved in the vacuolar sap of epidermal tissues flowers, fruits, leaves, stems. Delphinidin is one most common anthocyanins with heroprotective potential. In this study, we examined effect delphinidin on lifespan both male female Drosophila melanogaster. Our results showed concentration 10 µM causes a statistically significant decrease median melanogaster by 5% an increase females 4 %. However, mechanism action organism still understudied limits our understanding its properties. context, studying effects stress resistance, viability indicators, expression levels aging-related genes appears to be promising direction. Such studies would discover mechanisms heroprotection aging, as well answer question how natural like can used improve human health enlarge lifespan.

Language: Английский

Citations

0
Dietary Polyphenols as Geroprotective Compounds: From Blue Zones to Hallmarks of Ageing DOI Creative Commons
Sergio Davinelli, Alessandro Medoro, Frank B. Hu

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102733 - 102733

Published: March 1, 2025

Language: Английский

Citations

0
Toward a rational therapeutic for elastin related disease: key considerations for elastin based regenerative medicine strategies DOI

Meysam Ganjibakhsh,

Yana Tkachenko, Russell H. Knutsen

et al.

Matrix Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Antitumor properties of colored native potatoes (Solanum tuberosum ssp. tuberosum) from southern Chile DOI
Anita Behn,

Nicole Uribe,

Carina Chipón

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104969 - 104969

Published: Aug. 23, 2024

Language: Английский

Citations

0
Development of novel flavonoid senolytics through phenotypic drug screening and drug design DOI Creative Commons
Lei Zhang, Rahagir Salekeen,

Carolina Soto-Palma

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Accumulation of senescent cells drives aging and age-related diseases. Senolytics, which selectively kill cells, offer a promising approach for treating many Using cell-based phenotypic drug discovery that combines screening design, we developed two novel flavonoid senolytics, SR29384 SR31133, derived from the senolytic fisetin. These compounds demonstrated enhanced activities, effectively eliminating multiple cell types, reducing tissue senescence in vivo , extending healthspan mouse model accelerated aging. Mechanistic studies utilizing RNA-Seq, machine learning, network pharmacology, computational simulation suggest these senolytics target PARP1, BCL-xL, CDK2 to induce selective death. This phenotype-based coupled with mechanistic insights, represents key advancement developing next-generation senolyticss potential clinical applications

Language: Английский

Citations

0