Nature Herbal Medicine‐ Tissue Engineering Strategies for Regulate Cell Homeostasis in Bone Regeneration
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Bone
fractures,
especially
large
and
complex
defects,
continue
to
pose
significant
challenges
in
the
medical
field.
Current
treatments
often
rely
on
autografts
or
allografts
for
structural
support,
which
can
lead
problems
such
as
reduced
bioactivity,
infection
risks,
potential
pathogen
transmission.
Nature
herbal
medicine
(NHM),
including
herbs
extracts,
offers
a
promising
alternative
by
effectively
modulating
inflammatory
responses,
enhancing
osteoblast
function,
inhibiting
bone
resorption,
thereby
facilitating
fracture
repair.
However,
traditional
drug
delivery
methods
NHM
encounter
interactions,
poor
tissue
distribution,
patient
compliance.
Biomaterials,
engineered
interact
with
biological
systems,
play
essential
roles
repair,
mechanical
delivery.
When
used
carriers,
biomaterials
be
combined
form
stable
systems
that
further
promote
regeneration.
Here
applications
of
are
reviewed,
hydrogels,
extracellular
vesicles,
cement,
conjunction
regulating
homeostasis
aiming
provide
valuable
insights
guidance
future
research
therapeutic
strategies.
Язык: Английский
Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
285, С. 117148 - 117148
Опубликована: Окт. 1, 2024
Kashin-Beck
disease
(KBD)
is
an
endemic
osteoarthropathy
characterized
by
excessive
chondrocytes
apoptosis.
T-2
toxin
exposure
has
been
proved
to
be
its
etiology.
Connective
tissue
growth
factor
(CTGF)
exerts
a
profound
influence
on
cartilage
and
metabolism.
We
investigated
the
potential
role
of
CTGF
in
KBD
development
examined
alterations
under
stimulation.
Язык: Английский
Bioactive Compounds in Osteoarthritis: Molecular Mechanisms and Therapeutic Roles
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11656 - 11656
Опубликована: Окт. 30, 2024
Osteoarthritis
(OA)
is
the
most
common
and
debilitating
form
of
arthritis.
Current
therapies
focus
on
pain
relief
efforts
to
slow
disease
progression
through
a
combination
drug
non-drug
treatments.
Bioactive
compounds
derived
from
plants
show
significant
promise
due
their
anti-inflammatory,
antioxidant,
tissue-protective
properties.
These
natural
can
help
regulate
inflammatory
processes
metabolic
pathways
involved
in
OA,
thereby
alleviating
symptoms
potentially
slowing
progression.
Investigating
efficacy
these
agents
treating
osteoarthritis
addresses
growing
demand
for
health
solutions
creates
new
opportunities
managing
this
increasingly
prevalent
age-related
condition.
The
aim
review
provide
an
overview
use
some
bioactive
modulating
associated
pain.
Язык: Английский
Epicatechin Derivatives in Tissue Engineering: Antioxidant, Anti-Inflammatory, Regenerative Use
Tissue Engineering Part B Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Epicatechin
(EC)-based
derivatives
have
garnered
significant
attention
for
their
powerful
antioxidant,
anti-inflammatory,
anticancer,
and
antibacterial
properties,
all
of
which
are
attributed
to
the
phenolic
hydroxyl
groups
in
structure.
These
compounds
promising
regenerative
medicine,
particularly
as
bioactive
components
scaffolds.
This
review
provides
an
in-depth
analysis
mechanisms
by
EC-based
materials
enhance
tissue
repair,
examining
application
various
scaffold
forms,
such
hydrogels,
nanoparticles,
nanofibers.
study
also
addresses
challenges
stability
bioavailability
associated
with
ECs
proposes
encapsulation
techniques
overcome
these
barriers.
The
potential
clinical
benefits
medicine
role
fostering
advancements
engineering
discussed,
making
this
a
valuable
resource
guiding
future
studies
on
integration
into
practice.
Язык: Английский