European Thyroid Journal,
Год журнала:
2024,
Номер
13(4)
Опубликована: Июнь 13, 2024
Introduction
The
type
2
deiodinase
and
its
Thr92Ala-DIO2
polymorphism
have
been
linked
to
clinical
outcomes
in
acute
lung
injury
coronavirus
disease
2019
(COVID-19).
Objective
objective
was
identify
a
potential
association
between
body
composition
(appendicular
muscle
mass,
myosteatosis,
fat
distribution)
determine
whether
they
reflect
the
severity
or
mortality
associated
with
disease.
Methods
In
this
prospective
cohort
study
(June–August
2020),
181
patients
hospitalized
moderate-to-severe
COVID-19
underwent
non-contrast-enhanced
computed
tomography
(CT)
of
thorax
assess
composition,
laboratory
tests,
genotyping
for
polymorphism.
Results
total,
consecutive
were
stratified
into
three
subgroups
according
genotype:
Thr/Thr
(
n
=
64),
Thr/Ala
96),
Ala/Ala
21).
prevalence
low
area
(MA)
(<
92
cm²)
52.5%.
Low
MA
less
frequent
Ala/Thr
(44.8%)
than
(60.9%)
(61.9%)
P
0.027).
Multivariate
logistic
regression
analysis
confirmed
that
allele
reduced
risk
(41%
69%)
myosteatosis
(62%
72%)
compared
+
(overdominant
model).
Kaplan–Meier
curves
showed
mass
homozygosity
had
lower
survival
rates
other
groups.
Notably,
heterozygotes
≥92
cm²
exhibited
best
rate.
Conclusion
heterozygosity
is
increased
skeletal
COVID-19.
protective
effect
on
restricted
MA.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Апрель 27, 2022
Severe
acute
respiratory
syndrome-coronavirus
2
(SARS-CoV-2)
causes
a
wide
spectrum
of
clinical
manifestations,
with
progression
to
multiorgan
failure
in
the
most
severe
cases.
Several
biomarkers
can
be
altered
coronavirus
disease
2019
(COVID-19),
and
they
associated
diagnosis,
prognosis,
outcomes.
The
used
COVID-19
include
several
proinflammatory
cytokines,
neuron-specific
enolase
(NSE),
lactate
dehydrogenase
(LDH),
aspartate
transaminase
(AST),
neutrophil
count,
neutrophils-to-lymphocytes
ratio,
troponins,
creatine
kinase
(MB),
myoglobin,
D-dimer,
brain
natriuretic
peptide
(BNP),
its
N-terminal
pro-hormone
(NT-proBNP).
Some
these
readily
predict
severity,
hospitalization,
intensive
care
unit
(ICU)
admission,
mortality,
while
others,
such
as
metabolomic
proteomic
analysis,
have
not
yet
translated
practice.
This
narrative
review
aims
identify
laboratory
that
shown
significant
diagnostic
prognostic
value
for
risk
stratification
discuss
possible
application
novel
analytic
strategies,
like
metabolomics
proteomics.
Future
research
should
focus
on
identifying
limited
but
essential
number
easily
prognosis
outcome
COVID-19.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Дек. 19, 2022
Coronavirus
disease
2019
(COVID-19)
was
characterized
as
a
pandemic
in
March,
2020
by
the
World
Health
Organization.
COVID-19
is
respiratory
syndrome
that
can
progress
to
acute
distress
syndrome,
multiorgan
dysfunction,
and
eventually
death.
Despite
being
considered
disease,
it
known
other
organs
systems
be
affected
COVID-19,
including
thyroid
gland.
Thyroid
gland,
well
hypothalamus
pituitary,
which
regulate
functioning
of
most
endocrine
glands,
express
angiotensin-converting
enzyme
2
(ACE2),
main
protein
functions
receptor
SARS-CoV-2
binds
enter
host
cells.
In
addition,
gland
extremely
sensitive
changes
body
homeostasis
metabolism.
Immune
system
cells
are
targets
for
hormones
T3
T4
modulate
specific
immune
responses,
cell-mediated
immunity,
natural
killer
cell
activity,
antiviral
action
interferon
(IFN)
proliferation
T-
B-lymphocytes.
However,
studies
show
patients
with
controlled
hypothyroidism
hyperthyroidism
do
not
have
higher
prevalence
nor
they
worse
prognosis
when
infected
virus.
On
hand,
retrospective
observational
studies,
prospective
case
reports
published
last
two
years
reported
abnormal
function
related
infection
or
even
several
weeks
after
its
resolution.
Indeed,
variety
disorders
been
documented
patients,
non-thyroidal
illness
(NTIS),
subacute
thyroiditis
thyrotoxicosis.
has
already
consequence
administration
vaccines
against
SARS-CoV-2.
Overall,
data
revealed
may
occur
during
convalescence
post-COVID
condition
phase.
Although
cellular
molecular
mechanisms
completely
understood,
evidence
suggests
“cytokine
storm”
an
important
mediator
this
context.
Thus,
future
needed
better
investigate
pathophysiology
dysfunction
induced
at
both
clinical
levels.
Life,
Год журнала:
2022,
Номер
12(4), С. 517 - 517
Опубликована: Март 31, 2022
COVID-19
is
currently
considered
a
systemic
infection
involving
multiple
systems
and
causing
chronic
complications.
Compared
to
other
post-viral
fatigue
syndromes,
these
complications
are
wider
more
intense.
The
most
frequent
symptoms
profound
fatigue,
dyspnea,
sleep
difficulties,
anxiety
or
depression,
reduced
lung
capacity,
memory/cognitive
impairment,
hyposmia/anosmia.
Risk
factors
for
this
condition
severity
of
illness,
than
five
in
the
first
week
disease,
female
sex,
older
age,
presence
comorbidities,
weak
anti-SARS-CoV-2
antibody
response.
Different
lines
research
have
attempted
explain
protracted
symptoms;
persistent
inflammation,
autonomic
nervous
system
disruption,
hypometabolism,
autoimmunity
may
play
role.
Due
thyroid
high
ACE
expression,
key
molecular
complex
SARS-CoV-2
uses
infect
host
cells,
be
target
coronavirus
infection.
Thyroid
dysfunction
after
combination
numerous
mechanisms,
its
role
long-COVID
manifestations
not
yet
established.
proposed
mechanisms
direct
effect
on
an
indirect
inflammatory
immune
response,
hypothalamic-pituitary-thyroid
(HPT)
axis
leading
decreased
serum
TSH.
Only
few
studies
reported
gland
status
post-COVID-19
condition.
post-COVID
deserves
recognition
as
cause
syndrome.
It
important
recognize
affected
individuals
at
early
stage
so
we
can
offer
them
adequate
treatments,
helping
thrive
through
uncertainty
their
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 4, 2022
Objectives
Recently,
a
number
of
reports
have
described
the
potential
relationship
between
COVID-19
and
thyroid
hormones,
but
results
were
conflicting.
We
performed
meta-analysis
to
evaluate
effect
severity
on
thyroid-related
hormones
outcome
in
order
try
confirm
association
serum
levels
free
triiodothyronine
(FT3),
thyroxine
(FT4)
stimulating
hormone
(TSH)
or
mortality
coronavirus-19
patients.
Methods
The
methodology
was
already
registered
International
Prospective
Register
Systematic
Reviews
(PROSPERO)
database,
protocol
is
CRD42021269246.
searches
carried
out
Cochrane
Library,
Embase,
PubMed
Web
Science
databases
November
15,
2021.
set
up
literature
search
strategy
based
following
keywords:
[(T3
OR
FT3
triiodothyronine)
(T4
FT4
thyroxine)
(TSH
thyrotropin)]
(COVID-19
SARS-CoV-2),
without
time
restrictions.
Results
Twenty
studies
satisfied
inclusion/exclusion
criteria
included
meta-analysis.
A
total
3609
patients
enrolled
study.
From
analysis
studies,
incidence
abnormalities
higher
with
severe
COVID-19,
TSH
lower
than
those
nonsevere
COVID-19.
However,
difference
not
significant.
Similar
characteristics
shown
survivors
nonsurvivors.
In
addition,
outcomes
showed
that
abnormal
had
greater
mortality.
Conclusions
Low
levels,
low
may
increase
during
admission.
On
other
hand,
level
probability
decreases
FT3,
FT4,
levels.
Diagnostics,
Год журнала:
2022,
Номер
12(4), С. 960 - 960
Опубликована: Апрель 12, 2022
This
is
a
review
of
full-length
articles
strictly
concerning
subacute
thyroiditis
(SAT)
in
relation
to
the
SARS-CoV-2
virus
infection
(SVI)
and
COVID-19
vaccine
(COV)
that
were
published
between
1st
March
2020
21st
2022
PubMed-indexed
journals.
A
total
161
cases
reported
as
follows:
81
SAT-SVI
(2
retrospective
studies,
5
case
series,
29
reports),
80
respective
SAT-COV
(1
longitudinal
study,
14
17
reports;
also,
1
prospective
study
included
12
patients,
with
6
patients
each
category).
To
our
knowledge,
this
represents
largest
cohort
until
present
time.
was
detected
adults
aged
18
85
years,
mostly
middle-aged
females.
SAT-COVID-19
timing
classifies
SAT
viral
(synchronous
infection,
which
an
original
feature
SATs
usually
follow
infection)
post-viral
(during
recovery
period
or
after
within
8
weeks,
up
maximum
24
weeks).
The
clinical
spectrum
has
two
patterns:
either
accompanying
severe
multi-organ
spreading
(most
frequent
lung
involvement)
asymptomatic
being
single
manifestation
first
presentation.
Either
way,
may
remain
unrecognized.
Some
data
suggest
more
intense
neck
pain,
fever,
hypothyroidism
at
3
months
are
identified
when
compared
non-SAT-SVI,
but
other
authors
have
similar
presentations
outcomes.
Post-COVID-19
fatigue
be
due
residual
post-SAT
hypothyroidism.
practical
importance
derives
from
fact
thyroid
hormone
anomalies
aggravate
general
status
infections
(particular
concerns
tachycardia/arrhythmias,
cardiac
insufficiency,
ischemic
events).
If
misdiagnosed,
results
unnecessary
treatment
anti-thyroid
drugs
even
antibiotics
for
fever
unknown
cause.
Once
recognized,
does
not
seem
require
particular
approach
non-COVID-19
cases,
including
need
glucocorticoid
therapy
rate
permanent
complete
resolution
inflammation
expected,
except
persistent
follows
few
hours
average
2
weeks
(no
pattern
related
second
dose).
Pathogenesis
includes
molecular
mimicry
immunoinflammatory
anomalies,
some
suggested
part
ASIA
syndrome
(autoimmune/inflammatory
induced
by
adjuvants).
An
alternative
hypothesis
vaccine-related
increased
autoimmunity
vaccine-induced
hyperviscosity;
however,
supported
incomplete
evidence.
From
what
we
know
so
far
risk
factors,
prior
episode
non-SVI-SAT
associated
higher
SAT-COV,
nor
previous
history
coronavirus
itself.
Post-vaccine
less
presentation
good
outcome.
Generally,
female
sex
prone
developing
any
type
SAT.
HLA
susceptibility
probably
both
new
types
SATs.
current
low
level
statistical
evidence
expected
change
future.
Practitioners
should
aware
restrict
immunization
protocols
case.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 28, 2022
This
systematic
review
and
meta-analysis
was
conducted
to
evaluate
the
effect
of
COVID-19
on
thyroid
function
role
hormones
alterations
in
predicting
severity
COVID-19.
Online
databases,
including
Scopus,
Medline/PubMed,
EMBASE,
Google
Scholar,
Cochrane
were
searched
up
August
2,
2022.
After
screening
titles,
abstracts,
full
manuscripts,
respectively,
30
reports
enrolled.
The
risk
bias
(ROB)
evaluated
using
QUADAS-2
tool.
In
addition,
odds
ratio
(OR)
hazard
(HR)
analysis
for
assessing
OR
abnormal
tests
(TFT)
poor
outcomes.
Among
enrolled
studies,
ROB
current
study
is
estimated
low
moderate.
average
number
patients
each
325
(range:
40-3,703),
with
an
overall
mean
age
57.6,
female
proportion
40.4%.
Overall,
pooled
showed
that
prevalence
dysfunction
among
9,707
cases
15%.
mild
moderate
patients,
6.2%
had
TFT,
who
experienced
severe
critical
COVID-19,
20.8%
TFT.
TFT
obtained
from
3,865
3.77
(2.03,
6.99).
HR
TSH
level
mortality
1.57
(0.91,
2.72).
Our
results
demonstrate
a
high
3.77-fold
higher
compared
Further
studies
are
required
longer-term
prognostic
investigate
potential
therapeutic
strategies.
Annual Review of Medicine,
Год журнала:
2022,
Номер
74(1), С. 75 - 88
Опубликована: Сен. 24, 2022
The
multifaceted
interaction
between
coronavirus
disease
2019
(COVID-19)
and
the
endocrine
system
has
been
a
major
area
of
scientific
research
over
past
two
years.
While
common
endocrine/metabolic
disorders
such
as
obesity
diabetes
have
recognized
among
significant
risk
factors
for
COVID-19
severity,
several
organs
were
identified
to
be
targeted
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2).
New-onset
related
reported
while
long-term
effects,
if
any,
are
yet
determined.
Meanwhile,
“stay
home”
measures
during
pandemic
caused
interruption
in
care
patients
with
pre-existing
may
impeded
diagnosis
treatment
new
ones.
This
review
aims
outline
this
complex
synthesizing
current
knowledge
obtained
from
clinical
pathophysiological
studies,
emphasize
considerations
future
research.
Frontiers in Neurology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
This
study
intended
to
explore
associations
of
reverse
triiodothyronine
(rT3)
with
emotional
disturbances
and
health-related
quality
life
(HRQoL)
after
experiencing
acute
ischemic
stroke
(AIS).
Serum
samples
from
individuals
AIS
were
collected
on
admission
three
Lithuania
centers
investigated
for
free
tetraiodothyronine,
(fT3),
rT3,
thyroid
stimulating
hormone
levels.
At
discharge,
disturbance
was
evaluated
using
the
Hospital
Depression
Anxiety
Scale
(HADS),
HRQoL
EQ-5D-5L
scale.
Analyses
included
159
(59.7%
male
40.3%
female;
mean
(SD)
aged
66.4
[10.3]
years),
52.83%
which
showed
increased
rT3
levels
upon
admission.
After
adjustment
age,
sex,
National
Institutes
Health
Stroke
scores,
previous
stroke,
modified
Rankin
before
≤
2,
diabetes
mellitus,
multivariable
linear
regression
revealed
negative
HADS
total
score
(β
=
-0.163;
p
0.046)
HADS-D
subscale
-0.187;
0.019).
supported
a
positive
relationship
between
fT3
ratio
0.157;
×
product
EQ-5D
index
0.044
β
0.179;
0.023,
respectively).
We
found
that
who
experienced
had
higher
at
hospital
less
better
when
discharged.
Endocrine Connections,
Год журнала:
2022,
Номер
11(10)
Опубликована: Авг. 30, 2022
The
severity
of
coronavirus
disease
2019
(COVID-19)
has
been
positively
correlated
with
several
comorbidities.
primary
outcome
the
study
was
to
assess
relationship
between
mortality
and
COVID-19
obesity
classes
according
BMI,
visceral
adipose
tissue
(VAT)
area,
s.c.
muscle
area
(MA),
leptin
levels.In
this
prospective
cohort
study,
200
patients
hospitalized
moderate-to-severe
underwent
an
unenhanced
CT
thorax
laboratory
tests,
levels
June
August
2020
were
obtained.Our
included
(male
52%;
mean
age:
62
(49-74)
years;
(BMI
>
30):
51.5%)).
Fifty-eight
(23.5%)
admitted
intensive
care
unit
29
(14.5%)
died.
In
multivariate
logistic
regression
(corrected
for
leptin,
sex,
age,
serum
biomarkers)
receiver
operating
characteristic
curve
analyses,
high
VAT
150
cm2
(odds
ratio
(OR):
6.15;
P
<
0.002),
MA
92
(OR:
7.94;
0.005),
VAT/MA
2
13.9;
0.0001)
independent
risk
factors
mortality.
Indeed,
Kaplan-Meier
curves
showed
that
without
30)
had
a
lower
survival
rate
(hazard
3.89
9.66;
0.0006)
than
other
groups.
Leptin
not
related
severity.This
reports
data
on
largest
number
severe
pinpoints
calculated
by
as
predictors