Molecules, Год журнала: 2022, Номер 27(20), С. 7084 - 7084
Опубликована: Окт. 20, 2022
Aging is a very complex process that accompanied by degenerative impairment in many of the major functions human body over time. This inevitable influenced hereditary factors, lifestyle, and environmental influences such as xenobiotic pollution, infectious agents, UV radiation, diet-borne toxins, so on. Many external internal signs symptoms are related with aging senescence, including skin dryness wrinkles, atherosclerosis, diabetes, neurodegenerative disorders, cancer, etc. Oxidative stress, consequence imbalance between pro- antioxidants, one main provoking factors causing aging-related damages concerns, due to generation highly reactive byproducts oxygen nitrogen species during metabolism, which result cellular damage apoptosis. Antioxidants can prevent these processes extend healthy longevity ability inhibit formation free radicals or interrupt their propagation, thereby lowering level oxidative stress. review focuses on supporting antioxidant system organism balancing diet through consumption necessary amount natural ingredients, vitamins, minerals, polyunsaturated fatty acids (PUFA), essential amino acids, probiotics, plants’ fibers, nutritional supplements, polyphenols, some phytoextracts, drinking water.
Язык: Английский
Процитировано
111Vitamin D as a Shield against Aging
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4546 - 4546
Опубликована: Фев. 25, 2023
Aging can be seen as a physiological progression of biomolecular damage and the accumulation defective cellular components, which trigger amplify process, toward whole-body function weakening. Senescence initiates at level consists in an inability to maintain homeostasis, characterized by overexpression/aberrant expression inflammatory/immune/stress responses. is associated with significant modifications immune system cells, decline immunosurveillance, which, turn, leads chronic elevation inflammation/oxidative stress, increasing risk (co)morbidities. Albeit aging natural unavoidable it regulated some factors, like lifestyle diet. Nutrition, indeed, tackles mechanisms underlying molecular/cellular aging. Many micronutrients, i.e., vitamins elements, impact cell function. This review focuses on role exerted vitamin D geroprotection, based its ability shape cellular/intracellular processes drive response protection against infections age-related diseases. To this aim, main paths immunosenescence inflammaging are identified biotargets D. Topics such heart skeletal muscle function/dysfunction, depending status, addressed, comments hypovitaminosis correction food supplementation. research has progressed, still limitations exist translating knowledge into clinical practice, making necessary focus attention aging, especially considering growing number older individuals.
Язык: Английский
Процитировано
56Novel strategies for cancer immunotherapy: counter-immunoediting therapy
Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)
Опубликована: Апрель 13, 2023
Abstract The advent of immunotherapy has made an indelible mark on the field cancer therapy, especially application immune checkpoint inhibitors in clinical practice. Although proven its efficacy and safety some tumors, many patients still have innate or acquired resistance to immunotherapy. emergence this phenomenon is closely related highly heterogeneous microenvironment formed by tumor cells after undergoing immunoediting. process immunoediting refers cooperative interaction between system that involves three phases: elimination, equilibrium, escape. During these phases, conflicting interactions result formation a complex microenvironment, which contributes acquisition different levels cells. In review, we summarize characteristics phases corresponding therapeutic tools, propose normalized strategies based immunophenotyping. retrograded through targeted interventions immunoediting, making context precision therapy most promising cure cancer.
Язык: Английский
Процитировано
48A comprehensive review on the utilization of probiotics in aquaculture towards sustainable shrimp farming
Fish & Shellfish Immunology, Год журнала: 2024, Номер 147, С. 109459 - 109459
Опубликована: Фев. 17, 2024
Язык: Английский
Процитировано
22Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases
Biomedicines, Год журнала: 2024, Номер 12(5), С. 1023 - 1023
Опубликована: Май 7, 2024
The synergic role of vitamin D and the intestinal microbiota in regulation immune system has been thoroughly described literature. Vitamin deficiency dysbiosis have shown a pathogenetic development numerous immune-mediated allergic diseases. physiological processes underlying aging sex proven to be capable having negative influence both on values biodiversity microbiome. This leads global increase levels systemic inflammatory markers, with potential implications for all diseases conditions. Our review aims collect analyze relationship between microbiome associated it, emphasizing effect mediated by sexual hormones aging.
Язык: Английский
Процитировано
14Adherence to an antioxidant diet and lifestyle is associated with reduced risk of cardiovascular disease and mortality among adults with nonalcoholic fatty liver disease: evidence from NHANES 1999–2018
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Апрель 8, 2024
Background Nonalcoholic fatty liver disease (NAFLD) stands a prevalent chronic condition significantly influenced by oxidative stress. We investigated the unclear relationship between antioxidant-rich diet and lifestyle cardiovascular (CVD) prevalence rate mortality in adult patients with NAFLD. Methods This study utilized data from National Health Nutrition Examination Survey (NHAENS) spanning 1999 to 2018 investigate association adherence an The employed Oxidative Balance Score (OBS) define antioxidant lifestyle. Results Including 8,670 NAFLD, revealed inverse OBS of most CVD conditions. Fully adjusted models demonstrated that each unit increase OBS, overall corresponded 2, 7, 2% reduction all-cause mortality, respectively. In findings Q2 Q3 were linked reduced cancer whereas did not exhibit association. Additionally, Stratified analysis age (<45 years) education level (> high school) CVD. Conclusion These results underscore protective link diminished adults particularly among younger higher-educated populations.
Язык: Английский
Процитировано
12Intestinal toxicity of Pb: Structural and functional damages, effects on distal organs and preventive strategies
The Science of The Total Environment, Год журнала: 2024, Номер 931, С. 172781 - 172781
Опубликована: Апрель 27, 2024
Язык: Английский
Процитировано
10Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults
Drugs & Aging, Год журнала: 2025, Номер 42(1), С. 39 - 55
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Growing old together: What we know about the influence of diet and exercise on the aging host's gut microbiome
Frontiers in Sports and Active Living, Год журнала: 2023, Номер 5
Опубликована: Апрель 17, 2023
The immune system is critical in defending against infection from pathogenic microorganisms. Individuals with weakened systems, such as the elderly, are more susceptible to infections and developing autoimmune inflammatory diseases. gut microbiome contains a plethora of bacteria other microorganisms, which collectively plays significant role function homeostasis. Gut microbiota considered be highly influential on host health function. Therefore, dysbiosis could major contributor elevated incidence multiple age-related pathologies. While there seems general consensus that composition changes age, very little known about how diet exercise might influence aging microbiome. Here, we examine current state literature regarding alterations hosts drawing particular attention knowledge gaps addressing Further, will demonstrate need for controlled studies investigate roles play driving composition, diversity, an population.
Язык: Английский
Процитировано
21Postbiotics as potential new therapeutic agents for sepsis
Burns & Trauma, Год журнала: 2023, Номер 11
Опубликована: Янв. 1, 2023
Sepsis is the main cause of death in critically ill patients and gut microbiota dysbiosis plays a crucial role sepsis. On one hand, sepsis leads to destruction induces aggravates terminal organ dysfunction. other activation pathogenic flora reduction beneficial microbial products increase susceptibility host Although probiotics or fecal transplantation preserve barrier function on multiple levels, their efficacy with intestinal disruptions remains uncertain. Postbiotics consist inactivated cells cell components. They possess antimicrobial, immunomodulatory, antioxidant antiproliferative activities. Microbiota-targeted therapy strategies, such as postbiotics, may reduce incidence improve prognosis by regulating metabolites, improving integrity changing composition microbiota. offer variety mechanisms might even be superior more conventional 'biotics' prebiotics. In this review, we present an overview concept postbiotics summarize what currently known about prospective utility therapy. Overall, show promise viable adjunctive option for
Язык: Английский
Процитировано
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