Micronutrient Supplementation to Reduce Cardiovascular Risk

Journal of the American College of Cardiology, Год журнала: 2022, Номер 80(24), С. 2269 - 2285

Опубликована: Дек. 1, 2022

Язык: Английский

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Targeting aging mechanisms: pharmacological perspectives

Trends in Endocrinology and Metabolism, Год журнала: 2022, Номер 33(4), С. 266 - 280

Опубликована: Фев. 17, 2022

Язык: Английский

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Natural Antioxidant Evaluation: A Review of Detection Methods

Molecules, Год журнала: 2022, Номер 27(11), С. 3563 - 3563

Опубликована: Июнь 1, 2022

Antioxidants have drawn the attention of scientific community due to being related prevention various degenerative diseases. The antioxidant capacity has been extensively studied in vitro, and different methods used assess its activity. However, main issues studying natural antioxidants are evaluating whether these demonstrate a key role biological system assessing their bioavailability organism. majority outcomes literature controversial lack method standardization proper application. Therefore, this study aims compile concerning field study, comparing most common vitro evaluate activity compounds, demonstrating systems enzymes redox cellular signaling explaining how bioactive compounds is evaluated animal models human clinical trials.

Язык: Английский

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Associations of Serum Carotenoids With Risk of All‐Cause and Cardiovascular Mortality in Hypertensive Adults

Journal of the American Heart Association, Год журнала: 2023, Номер 12(4)

Опубликована: Фев. 8, 2023

Background Systemic oxidative stress is involved in the development of hypertension, whereas carotenoids are a group natural antioxidants. Our study aims to evaluate relationships between serum concentrations major and mortality hypertensive adults. Methods Results Data on 5 from National Health Nutrition Examination Survey (NHANES) III NHANES 2001-2006 were included. Outcome measures (all-cause cardiovascular mortality) identified Death Index through December 31, 2019. Multiple Cox proportional hazards regression restricted cubic spline analyses performed determine association carotenoid levels outcomes. A total 8390 adults included analysis. At median follow-up duration 16.6 years, all-cause occurred 4005 (47.74%) 1205 (14.36%) participants, respectively. Compared with lowest quartiles, highest quartiles associated lower risk mortality, multivariable-adjusted hazard ratios (HRs) 0.63 (95% CI, 0.56-0.71) for α-carotene, 0.70 0.61-0.80); β-carotene, 0.67 0.58-0.76); β-cryptoxanthin, 0.74 0.64-0.86) lycopene; 0.72 0.63-0.83) lutein/zeaxanthin. For cause-specific this fourth quartile was evident reduced rate 32% reduction α-carotene (HR, 0.68 [95% 0.55-0.86]), 29% β-cryptoxanthin 0.71 0.56-0.89]), 26% lycopene 0.59-0.94]), but not β-carotene In addition, we found that lutein/zeaxanthin nonlinearly related inflection points 2.43, 8.49, 5.12, 14.17 μg/dL, Serum showed nonlinear associations 2.31, 5.26, 15.40 Conclusions Findings suggest higher risks

Язык: Английский

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Composite dietary antioxidant index is inversely and nonlinearly associated with cardiovascular disease, atherosclerotic cardiovascular disease, and cardiovascular mortality in people with dyslipidemia: evidence from NHANES 2001–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Dyslipidemia is a major risk factor for cardiovascular disease (CVD) and atherosclerotic CVD (ASCVD). The composite dietary antioxidant index (CDAI), an emerging measure of combined exposure, may provide insights into the relationship between diet CVD/ASCVD outcomes. We aimed to explore association CDAI prevalence CVD/ASCVD, as well mortality in individuals with dyslipidemia. was assessed by integrating vitamins A, C, E, zinc, selenium, carotenoids. diagnosed according widely established criteria. Data on were obtained through self-reports, while prospective matching participant records National Death Index database. Multivariate logistic regression analysis Cox proportional hazards used these associations calculate odds ratios [OR], hazard [HR], 95% confidence intervals [CI], respectively. A total 23,126 participants dyslipidemia from NHANES 2001-2018 included. After adjusting potential confounders, inversely associated both ASCVD populations (OR CI 0.979 (0.964, 0.995) 0.977 (0.961, 0.993), respectively). Similar observed specific types CVD. also (HR = 0.957, 0.939-0.976, p < 0.0001). Restricted cubic spline threshold effects analyses indicated that nonlinearly significant occurring only when CDAI≤0; however, > -2. Furthermore, age, sex, drinking found modify body mass influenced mortality. events dyslipidemic populations. These findings highlight patterns alleviate burden underscore importance personalized strategies.

Язык: Английский

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Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 24, 2025

The evidence regarding dietary antioxidant intake and all-cause cardiovascular disease (CVD) mortality among patients with hypertension is scarce. This study included 16,190 adults from the National Health Nutrition Examination Survey (NHANES) 1999–2018. Death outcomes were ascertained by linkage to Index records through December 31, 2019. Overall was estimated composite index (CDAI). Cox proportional hazards models used estimate risk for CVD mortality. Kaplan–Meier curve illustrate survival probabilities CDAI quartiles. Weighted quantile sum (WQS) regression conducted evaluate joint independent associations of antioxidants median (interquartile range) age participants 59.00 (47.00, 69.00) years. During a 94 months follow-up, 3,858 deaths documented. Compared lowest quartile CDAI, multivariable adjusted HR 95% CI highest 0.76 (0.64, 0.91) (Q4) vitamin E (HR = 0.69; CI, 0.59–0.80), selenium 0.84; 0.70–1.00) total carotenoids 0.86; 0.75–0.98) intakes negatively associated Vitamin might be major contributors this negative relationship. 0.72; 0.56–0.93) Higher overall significantly decreased hypertension. Further randomized controlled trials are required confirm our findings.

Язык: Английский

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Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease

Journal of the American College of Cardiology, Год журнала: 2021, Номер 77(1), С. 45 - 54

Опубликована: Янв. 1, 2021

Язык: Английский

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Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

Cancers, Год журнала: 2020, Номер 12(9), С. 2425 - 2425

Опубликована: Авг. 26, 2020

An incidence and mortality of cancer are rapidly growing worldwide, especially due to heterogeneous character the disease that is associated with irreversible impairment cellular homeostasis function. Targeting apoptosis, one hallmarks, represents a potent treatment strategy. Carotenoids phytochemicals represented by carotenes, xanthophylls, derived compounds such as apocarotenoids demonstrate broad spectrum anti-cancer effects involving pro-apoptotic signaling through extrinsic intrinsic pathways. As demonstrated in preclinical oncology research, apoptotic modulation performed at post-genomic levels. Further, carotenoids additive/synergistic action combination conventional oncostatic agents. In addition, sensitization tumor cells can be achieved carotenoids. The disadvantage application their low solubility and, therefore, poor bioavailability. However, this deficiency improved using nanotechnological approaches, solid dispersions, microemulsions or biofortification significantly increase efficacy Only limited number studies dealing potential has been published clinical sphere. Pro-apoptotic should beneficial for individuals high risk development. article considers utility framework 3P medicine.

Язык: Английский

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Clinical Advances in Immunonutrition and Atherosclerosis: A Review

Frontiers in Immunology, Год журнала: 2019, Номер 10

Опубликована: Апрель 24, 2019

Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries considered to be major underlying cause of cardiovascular (CVD). The high risk mortality by atherosclerosis has led the development new strategies for prevention management, including immunonutrition. Plant-based dietary patterns, functional foods, supplements bioactive compounds such as Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 ω-6, vitamins E, A, C D, coenzyme Q10, well phytochemicals isoflavones, stilbenes sterols have been associated with improvement in atheroma plaque at an level. However, many these correlations obtained vitro experimental animals models. On one hand, present review focuses on evidence from epidemiological, intervention supplementation studies humans supporting role immunonutrient its effect anti-inflammatory response atherosclerotic disease. other this also analyzes possible molecular mechanisms protective action supplements, which may lead novel therapeutic approach prevent or attenuate diet-related disease, atherosclerosis.

Язык: Английский

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Definition of the Traditional Mexican Diet and Its Role in Health: A Systematic Review

Nutrients, Год журнала: 2019, Номер 11(11), С. 2803 - 2803

Опубликована: Ноя. 17, 2019

Promoting traditional diets could potentially reduce the current high rates of non-communicable diseases (NCDs) globally. While Mexican diet (TMexD) be specifically promoted in Mexico, a concise definition TMexD and evidence its association with NCDs are needed before promotion. To evaluate what constitutes this pattern, we aimed to systematically review, for first time, how has been described literature date. A secondary aim was examine whether TMexD, as by available definitions, is associated NCD outcomes. We searched records describing whole up July 2019 12 electronic databases, reference lists, relevant journal, contacting experts on topic. reported results using Preferred Reporting Items Systematic reviews Meta-Analyses (PRISMA) guidelines. included 61 six The food groups characterising that were consistently mentioned all study subgroups grains tubers, legumes, vegetables; specific foods maize, beans, chile, squash, tomato, onion. Other also mentioned, although lesser frequency, maize products, fruits, beverages, fish seafood, meats, sweets sweeteners, herbs condiments. Only few studies frequency consumption or amounts which these consumed TMexD. It not possible reach strong conclusions between adherence weakly developing breast cancer, triglyceride levels, inconsistently obesity diabetes However, limited small number (n = 6), most observational nature evaluated different definitions. These findings provide identified characteristics More ascertain exact quantities order establish dietary pattern health should within population.

Язык: Английский

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