Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid

Science Advances, Год журнала: 2024, Номер 10(8)

Опубликована: Фев. 21, 2024

After acute infection with severe respiratory syndrome coronavirus-2 (SARS-CoV-2), a proportion of patients experience persistent symptoms beyond 12 weeks, termed Long Covid. Understanding the mechanisms that cause this debilitating disease and identifying biomarkers for diagnostic, therapeutic, monitoring purposes are urgently required. We detected persistently high levels interferon-γ (IFN-γ) from peripheral blood mononuclear cells Covid using highly sensitive FluoroSpot assays. This IFN-γ release was seen in absence ex vivo peptide stimulation remains elevated Covid, unlike resolution recovering SARS-CoV-2 infection. The CD8

Язык: Английский

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Pathophysiological, immunological, and inflammatory features of long COVID

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 28, 2024

The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing substantial social economic burdens on nations. While most of the attention therapeutic efforts have concentrated acute phase disease, a notable proportion survivors experience persistent symptoms post-infection clearance. This diverse set symptoms, loosely categorized as long COVID, presents potential additional public health crisis. It is estimated that 1 5 exhibit clinical manifestations consistent with COVID. Despite this prevalence, mechanisms pathophysiology COVID remain poorly understood. Alarmingly, evidence suggests cases within condition develop debilitating or disabling symptoms. Hence, urgent priority should be given further studies equip systems for its management. review provides an overview available information emerging condition, focusing affected individuals’ epidemiology, pathophysiological mechanisms, immunological inflammatory profiles.

Язык: Английский

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Cluster analysis of long COVID in Japan and association of its trajectory of symptoms and quality of life

BMJ Open Respiratory Research, Год журнала: 2024, Номер 11(1), С. e002111 - e002111

Опубликована: Фев. 1, 2024

Background Multiple prolonged symptoms observed in patients who recovered from COVID-19 are defined as long COVID. Although diverse phenotypic combinations possible, they remain unclear. This study aimed to perform a cluster analysis of COVID Japan and clarify the association between its characteristics background factors quality life (QOL). Methods multicentre prospective cohort collected various QOL after January 2020 February 2021. included 935 aged ≥18 years with at 26 participating medical facilities. Hierarchical was performed using 24 symptom 3 months diagnosis. Results Participants were divided into following five clusters: numerous across multiple organs (cluster 1, n=54); no or minor 2, n=546); taste olfactory disorders 3, n=76); fatigue, psychoneurotic dyspnoea (low prevalence cough sputum) 4, n=207) fatigue (high 5, n=52). Cluster 1 elderly severe symptoms, while young female mild symptoms. No significant differences comorbidities. showed most impaired QOL, followed by clusters 4 5; these changes well composition over year. Conclusions We identified clusters. Future different pathologies could result individualised treatment Trial registration number The protocol is registered UMIN clinical trials registry (UMIN000042299).

Язык: Английский

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Characteristics and burden of acute COVID-19 and long-COVID: Demographic, physical, mental health, and economic perspectives

PLoS ONE, Год журнала: 2024, Номер 19(1), С. e0297207 - e0297207

Опубликована: Янв. 22, 2024

Background COVID-19 infection and its associated consequence, known as long-COVID, lead to a significant burden on the global healthcare system limitations in people’s personal work lives. This study aims provide further insight into impact of acute ongoing symptoms investigates role patients’ gender vaccination status. Methods 416 individuals (73.9% female) between ages 16 80 years ( M = 44.18, SD 12.90) with self-reported long-COVID participated an online survey conducted March May 2022. Results 6.0%, 74.3%, 19.7% all respondents reported having had asymptomatic, mild, or severe illness, respectively. Out participants, 7.8% required hospitalization. The most prevalent during Mdn 23.50 symptoms, IQR 13–39) included fatigue, exhaustion, cough, brain fog, memory problems. median disease duration was 12.10 months 2.8–17.4). Among 64 inquired 17.00 9–27), participants problems, dyspnea common which were generally experienced fluctuating deteriorating after physical cognitive activity. Common consequences financial losses (40.5%), changes participants’ profession (41.0%), stress resistance (87.5%), sexual life (38.1%), mood (72.1%), well breathing difficulties (41.3%), increased drug intake (e.g., medicine, alcohol; 44.6%). In addition, vaccinated exhibited shorter illness earlier onset symptoms. general, women more than men. Conclusion Long-COVID represents heterogeneous impacts multiple aspects those affected. Tailored rehabilitation programs targeting plurality mental are needed.

Язык: Английский

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Scent of COVID-19: Whole-Genome Sequencing Analysis Reveals the Role of ACE2, IFI44, and NDUFAF4 in Long-Lasting Olfactory Dysfunction

Life, Год журнала: 2025, Номер 15(1), С. 56 - 56

Опубликована: Янв. 5, 2025

COVID-19-related persistent olfactory dysfunction (OD) presents remarkable interindividual differences, and little is known about the host genetic factors that are involved in its etiopathogenesis. The goal of this study was to explore underpinning OD through analysis Whole Genome Sequencing data 153 affected subjects, focusing on genes antiviral response regulation. An innovative approach developed, namely assessment association between a "gene score", defined as ratio number homozygous alternative variants within gene length, participants' function. highlighted how an increased score ACE2 associated with worse performance, while IFI44 NDUFAF4 better Considering physiological role proteins encoded by these genes, it can be hypothesized reduced expression may protracted severe inflammatory epithelium, thus worsening patients' smell abilities. Conversely, might decreased response, correlating performance. Overall, identified new play pivotal determining heterogeneity, possibly enabling more personalized effective clinical management for individuals.

Язык: Английский

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Long COVID management: a mini review of current recommendations and underutilized modalities

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Июнь 14, 2024

Long COVID is a condition that develops in subset of patients after COVID-19 infection comprising symptoms varying severity encompassing multiple organ systems. Currently, long without consensus on formal definition, identifiable biomarkers, and validated treatment. expected to be long-term chronic for associated with suffering incapacity. There an urgent need clear management guidelines the primary care provider, who essential bridging gap more specialized improve quality life functionality their living COVID. The purpose this mini review provide providers latest highlights from existing literature regarding most common current recommendations. This also underutilized interventions stellate ganglion blocks low-dose naltrexone, both well-established safety profiles demonstrated some COVID, encourages prompt referral interventional pain management.

Язык: Английский

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Cardiovascular disease and covid-19: A systematic review

IJC Heart & Vasculature, Год журнала: 2024, Номер 54, С. 101482 - 101482

Опубликована: Авг. 2, 2024

Cardiovascular complications of COVID-19 are numerous and aspects this phenomenon not well known. The main objective manuscript is a systematic review the acute chronic cardiovascular secondary to COVID-19. A literature through Medline via PubMed was conducted (2020-2024). There plethora effects on heart in setting. Here we discuss pathophysiology, myocardial infarctions, failure, Takotsubo Cardiomyopathy, injury, myocarditis arrhythmias that caused by Additionally, these injuries can linger may be an underlying cause some Long COVID symptoms. life-threatening. affect health. Microclotting induced SARS-CoV-2 infection could therapeutic target for Covid.

Язык: Английский

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Evaluating the Predictors of Persistent Long COVID Symptoms and Their Severity in COVID-19 Survivors 1 Year After Infection

Journal of Primary Care & Community Health, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

As the coronavirus disease 2019 (COVID-19) pandemic progressed, virus was found to cause long-term health complications known as long COVID (LC). This study aimed investigate LC symptom severity and factors associated with likelihood of persistence beyond 1 year among COVID-19 survivors in Saudi Arabia.

Язык: Английский

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The Association Between Self-Reported Long COVID Symptoms and COVID-19 Conspiracy Theories in Jordan, Kuwait, among Other Arab Countries

Опубликована: Авг. 8, 2024

Long COVID comprises persistent symptoms which extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries where high these reported. This study aimed to explore endorsing prevalence self-reported among adults Jordan Kuwait addition other countries. employed a cross-sectional design using an electronic self-administered survey Arabic language. Recruitment utilized snowball sampling via social media was distributed July 2024. instrument included sections on demographic information, history infection, vaccination status. manifestations were assessed score reflecting frequency intensity ten recognized with subsequent categorization into three categories: low, middle, high. beliefs measured 5-point Likert scale across five items. final sample comprised 756 respondents, majority whom confirmed diagnosis at least once (n = 493, 65.2%). results indicated neutral average attitude towards (mean 15.18±4.64 out 30.00). Participants scores significantly more likely report (aOR 6.85, 95% CI: 2.90–16.13, p < 0.001) middle 2.82, 1.32–6.06, 0.008) compared those lower scores. Additional predictors higher reporting female sex household income. Frequent infections hospitalizations also associated symptom reporting. revealed significant correlation magnitude findings highlighted influence sociodemographic factors infection reporting, suggests that public health strategies should address mitigate challenges effectively.

Язык: Английский

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The Association between Self-Reported Long COVID Symptoms and COVID-19 Conspiracy Theories in Jordan and Kuwait

COVID, Год журнала: 2024, Номер 4(9), С. 1440 - 1462

Опубликована: Сен. 12, 2024

Long COVID comprises persistent symptoms that extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries, where high these reported. This study aimed to explore endorsing prevalence self-reported among adults Jordan Kuwait addition other countries. employed a cross-sectional design using Computer-Assisted Web Interviewing (CAWI), conducted Arabic. Recruitment utilized convenience-based snowball sampling via social media survey was distributed July 2024. manifestations were assessed across ten recognized symptoms, belief measured five-point Likert scale five items. final sample comprised 755 respondents, majority whom history confirmed diagnosis at least once (n = 493, 65.2%). results indicated neutral average attitude towards (mean score 15.18 ± 4.64 out 30.00). Participants with scores more likely report (aOR 6.85, p < 0.001) or middle 2.82, 0.008) compared those lower scores. Additional predictors higher reporting included female sex, household income, frequent infections, hospitalizations. revealed significant correlation frequency magnitude symptom reporting. findings also highlighted influence sociodemographic factors infection on reporting, which suggests public health strategies should address mitigate challenges effectively.

Язык: Английский

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