Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 17, 2024
The
study
of
energy
transduction
in
eukaryotic
cells
has
been
divided
between
Bioenergetics
and
Physiology,
reflecting
contributing
to
a
variety
Bioenergetic
myths
considered
here:
1)
ATP
production
=
production,
2)
is
confined
mitochondria
(plus
glycolysis
chloroplasts),
3)
only
produce
heat
when
required,
4)
inefficient
compared
mitochondria,
5)
are
the
main
source
reactive
oxygen
species
(ROS)
cells.
These
constitute
‘mitocentric’
view
cell
that
wrong
or
unbalanced.
In
reality,
site
dissipation
cells,
this
an
essential
function
mammals.
Energy
ROS
occur
throughout
cell,
particularly
cytosol
plasma
membrane,
all
membranes
act
as
two-dimensional
conduits.
Glycolysis
efficient,
produces
less
per
than
which
might
explain
its
increased
use
muscle
cancer
Frontiers in Human Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Март 18, 2024
Non-invasive
brain
stimulation
(NIBS)
is
a
complex
and
multifaceted
approach
to
modulating
activity
holds
the
potential
for
broad
accessibility.
This
work
discusses
mechanisms
of
four
distinct
approaches
non-invasively:
electrical
currents,
magnetic
fields,
light,
ultrasound.
We
examine
dual
stochastic
deterministic
nature
its
implications
NIBS,
highlighting
challenges
posed
by
inter-individual
variability,
nebulous
dose-response
relationships,
biases
neuroanatomical
heterogeneity.
Looking
forward,
we
propose
five
areas
opportunity
future
research:
closed-loop
stimulation,
consistent
intended
target
region,
reducing
bias,
multimodal
approaches,
strategies
address
low
sample
sizes.
Abstract
Body
temperature
variations,
including
the
generation,
transfer,
and
dissipation
of
heat,
play
an
important
role
throughout
life
participate
in
all
biological
events.
Cellular
information
is
indispensable
link
comprehensive
understanding
science
processes,
but
traditional
testing
strategies
cannot
provide
sufficient
due
to
their
low
precision
inefficient
cellular‐entrance.
In
recent
years,
with
help
luminescent
nanomaterials,
a
variety
new
thermometers
have
been
developed
achieve
real‐time
measurement
at
micro/nano
scale.
this
review,
we
summarized
latest
advances
several
nanoparticles
for
cellular
detection
related
applications
revealing
cell
metabolism
disease
diagnosis.
Furthermore,
review
proposed
few
challenges
nano‐thermometry,
expecting
spark
novel
thought
push
forward
its
preclinical
translational
uses.
Cellular
circadian
rhythms
confer
temporal
organisation
upon
physiology
that
is
fundamental
to
human
health.
Rhythms
are
present
in
red
blood
cells
(RBCs),
the
most
abundant
cell
type
body,
but
their
physiological
function
poorly
understood.
Here,
we
a
novel
biochemical
assay
for
haemoglobin
(Hb)
oxidation
status
which
relies
on
redox-sensitive
covalent
haem-Hb
linkage
forms
during
SDS-mediated
lysis.
Formation
of
this
lowest
when
ferrous
Hb
oxidised,
form
ferric
metHb.
Daily
observed
mouse
and
RBCs
cultured
vitro,
or
taken
from
humans
vivo,
unaffected
by
mutations
affect
nucleated
cells.
These
correlate
with
daily
core
body
temperature,
temperature
metHb
levels
highest.
Raising
dietary
sodium
nitrite
can
further
decrease
daytime
mice
via
nitric
oxide
(NO)
signalling.
results
extend
our
molecular
understanding
RBC
suggest
they
contribute
regulation
temperature.
Circulation Research,
Год журнала:
2024,
Номер
134(6), С. 711 - 726
Опубликована: Март 14, 2024
The
brain
is
a
complex
organ,
fundamentally
changing
across
the
day
to
perform
basic
functions
like
sleep,
thought,
and
regulating
whole-body
physiology.
This
requires
symphony
of
nutrients,
hormones,
ions,
neurotransmitters
more
be
properly
distributed
maintain
homeostasis
throughout
24
hours.
These
solutes
are
both
by
blood
cerebrospinal
fluid.
Cerebrospinal
fluid
contents
distinct
from
general
circulation
because
regulation
at
barriers
including
choroid
plexus,
glymphatic
system,
blood-brain
barrier.
In
this
review,
we
discuss
overlapping
circadian
(≈24-hour)
rhythms
in
biology
barriers.
Our
goal
for
reader
gain
fundamental
understanding
alongside
an
interactions
between
these
fluids
timing
system.
Ultimately,
review
will
provide
new
insight
into
how
alterations
finely
tuned
clocks
may
lead
pathology.
Pharmacological Reviews,
Год журнала:
2023,
Номер
75(6), С. 1140 - 1166
Опубликована: Июнь 16, 2023
Pharmacological
agents
used
to
treat
or
manage
diseases
can
modify
the
level
of
heat
strain
experienced
by
chronically
ill
and
elderly
patients
via
different
mechanistic
pathways.
Human
thermoregulation
is
a
crucial
homeostatic
process
that
maintains
body
temperature
within
narrow
range
during
stress
through
dry
(i.e.,
increasing
skin
blood
flow)
evaporative
sweating)
loss,
as
well
active
inhibition
thermogenesis,
which
avoid
overheating.
Medications
independently
synergistically
interact
with
ageing
chronic
disease
alter
responses
rising
stress.
This
review
focuses
on
physiological
changes,
specific
emphasis
thermolytic
processes,
associated
medication
use
The
begins
providing
readers
background
global
burden.
effects
are
then
summarised
give
an
understanding
unique
changes
faced
older
adults.
common
regulation
outlined
in
main
sections.
Physiological
impacts
medications
these
reviewed
detail,
mechanisms
thermolysis
concludes
perspectives
need
understand
hot
environments,
summary
table
all
clinical
considerations
research
needs
included
this
review.
Significance
Statement
Long-term
modulate
thermoregulatory
function,
resulting
excess
predisposing
adverse
health
outcomes
prolonged
exposures
extreme
rest
physical
work
(e.g.,
exercise).
Understanding
medication-specific
altered
has
importance
both
fraternities,
paving
way
for
towards
refining
current
prescription
recommendations
formulating
mitigation
strategies
drug
patients.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
160, С. 114287 - 114287
Опубликована: Янв. 27, 2023
Brain
temperature
determines
not
only
an
individual's
cognitive
functionality
but
also
the
prognosis
and
mortality
rates
of
many
brain
diseases.
More
specifically,
changes
in
response
to
different
physiological
events
like
yawning
stretching,
plays
a
significant
pathophysiological
role
number
neurological
neuropsychiatric
illnesses.
Here,
we
have
outlined
function
hyperthermia
both
diseased
healthy
states,
focusing
particularly
on
amyloid
beta
aggregation
Alzheimer's
disease.
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Understanding
temperature
sensitivity
in
magnetic
resonance
is
key
to
novel
molecular
probes
for
noninvasive
mapping.
Herein,
we
report
an
investigation
of
the
effects
heavy-donor-atom
dithiocarbamate
ligands
on
variable-temperature
59Co
nuclear
(NMR)
properties
six
Co(III)
complexes:
Co(et2-dtc)3
(1),
Co(bu2-dtc)3
(2),
Co(hex2-dtc)3
(3),
Co(pyrr-dtc)3
(4),
Co(benzyl2-dtc)3
(5)
and
Co(2,6-dmpip-dtc)3
(6)
(et2-dtc
=
diethyldithiocarbamate;
bu2-dtc
dibutyldithiocarbamate;
hex2-dtc
dihexyldithiocarbamate;
pyrr-dtc
pyrrolidine-dithiocarbamate;
benzyl2-dtc
dibenzyldithiocarbamate;
2,6-dmpip-dtc
2,6-dimethylpiperidine-dithiocarbamate).
This
study
reveals
chemical-shift
dependences
1.17(3)-1.73(4)
ppm/°C
as
a
function
ligand
substituents.
Solid-state
Raman
spectroscopic
analyses
show
that
more
Raman-active
Co-S6
vibrational
modes
correlate
higher
thermal
sensitivities
these
compounds,
line
with
our
current
model
sensitivity.
Short
spin-lattice
relaxation
T1
times
solution
(ca.
200
μs)
were
observed,
correlation
T2*
solid-state
NMR
reveal
solution-phase
widths
are
attributable
quadrupolar
processes,
which
ultimately
lower
temperature-sensing
resolution.
Abstract
Near‐infrared
(NIR)
fluorescent
proteins
and
optogenetic
tools
derived
from
bacterial
phytochromes'
photosensory
core
modules
(PCMs)
operate
within
the
first
(NIR‐I)
tissue
transparency
window
under
single‐photon
activation.
Leveraging
two‐photon
(2P)
light
in
second
(NIR‐II)
for
photoswitching
phytochromes
between
Pr
Pfr
absorption
states
offers
significant
advantages,
including
enhanced
penetration,
spatial
resolution,
signal‐to‐noise
ratio.
However,
2P
photoconversion
of
remains
understudied.
Here,
we
study
non‐linear
to
photoconversion's
dependence
on
irradiation
wavelength
(1180–1360
nm)
energy
fluence
(41–339
mJ/cm
2
)
PCM
Dr
BphP
phytochrome.
Our
findings
reveal
substantially
higher
efficiency
engineered
monomeric
BphP‐PCM
(73%)
compared
natural
dimeric
(57%).
Molecular
mechanical
calculations,
based
experimentally
determined
cross‐section
coefficients
monomer
(167
GM)
dimer
(170
GM),
further
verify
these
results.
We
demonstrate
both
short‐
(SWE)
long‐wavelength
excitation
(LWE)
fluorescence
Soret
band
using
405
810–890
nm
laser
sources,
respectively.
Under
LWE,
emission
(724
exhibits
saturation
at
a
peak
power
density
1.5
GW/cm
.
For
SWE,
observe
linear
degradation
BphP‐PCMs,
decreasing
by
32%
as
temperature
rises
19
38°C.
Conversely,
BphP‐PCM's
brightness
increases
up
182%
(at
37°C),
surpassing
form's
rise
39%.
These
establish
promising
template
developing
NIR
imaging
probes
operating
optimal
parameters
its
LWE
fluorescence.
