Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids
Exploration of neuroscience,
Год журнала:
2025,
Номер
4
Опубликована: Март 24, 2025
The
SAR-CoV-2
virus
has
evolved
to
co-exist
with
human
hosts,
albeit
at
a
substantial
energetic
cost
resulting
in
post-infection
neurological
manifestations
[Neuro-post-acute
sequelae
of
SARS-CoV-2
infection
(PASC)]
that
significantly
impact
public
health
and
economic
productivity
on
global
scale.
One
the
main
molecular
mechanisms
responsible
for
development
Neuro-PASC,
individuals
all
ages,
is
formation
inadequate
proteolysis/clearance
phase-separated
amyloid
crystalline
aggregates—a
hallmark
feature
aging-related
neurodegenerative
disorders.
Amyloidogenesis
during
viral
persistence
natural,
inevitable,
protective
defense
response
exacerbated
by
SARS-CoV-2.
Acting
as
chemical
catalyst,
accelerates
hydrophobic
collapse
heterogeneous
nucleation
amorphous
amyloids
into
stable
β-sheet
aggregates.
clearance
aggregates
most
effective
slow
wave
sleep,
when
high
levels
adenosine
triphosphate
(ATP)—a
biphasic
modulator
biomolecular
condensates—and
melatonin
are
available
solubilize
removal.
dysregulation
mitochondrial
dynamics
SARS-CoV-2,
particular
fusion
fission
homeostasis,
impairs
proper
distinct
subpopulations
can
remedy
challenges
created
diversion
substrates
away
from
oxidative
phosphorylation
towards
glycolysis
support
replication
maintenance.
subsequent
reduction
ATP
inhibition
synthesis
sleep
results
incomplete
brain
aggregates,
leading
commonly
associated
age-related
Exogenous
not
only
prevents
dysfunction
but
also
elevates
production,
effectively
augmenting
solubilizing
effect
moiety
ensure
timely,
optimal
disaggregation
pathogenic
prevention
attenuation
Neuro-PASC.
Язык: Английский
MENSA, a Media Enriched with Newly Synthesized Antibodies, to Identify SARS-CoV-2 Persistence and Latent Viral Reactivation in Long-COVID
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 7, 2024
ABSTRACT
Post-acute
sequelae
of
SARS-CoV-2
(SARS2)
infection
(PASC)
is
a
heterogeneous
condition,
but
the
main
viral
drivers
are
unknown.
Here,
we
use
MENSA,
Media
Enriched
with
Newly
Synthesized
Antibodies,
secreted
exclusively
from
circulating
human
plasmablasts,
to
provide
an
immune
snapshot
that
defines
underlying
triggers.
We
proof-of-concept
testing
MENSA
technology
can
capture
new
host
response
accurately
diagnose
acute
primary
and
breakthrough
infections
when
known
SARS2
virus
or
proteins
present.
It
also
positive
after
vaccination
spike
elicit
response.
Applying
same
principles
for
long-COVID
patients,
in
40%
PASC
vs
none
COVID
recovered
(CR)
patients
without
any
demonstrating
ongoing
inflammation
only
PASC.
Additionally,
MENSAs
Epstein-Barr
Virus
(EBV)
37%,
Human
Cytomegalovirus
(CMV)
23%,
herpes
simplex
2
(HSV2)
15%
compared
17%,
4%,
4%
CR
controls
respectively.
Combined,
total
60%
have
SARS2,
EBV,
CMV,
and/or
HSV2.
offers
unique
antibody
reveal
thus
persistence
reactivation
patients.
Graphical
abstract
Язык: Английский
Preeclampsia in pregnant women with COVID-19: a prospective cohort study from two tertiary hospitals in Southern Brazil
PeerJ,
Год журнала:
2024,
Номер
12, С. e17481 - e17481
Опубликована: Июнь 11, 2024
Background
COVID-19
is
an
infectious
pathology
that
shows
vascular
changes
during
pregnancy,
as
well
in
the
placentas.
The
main
objectives
of
this
study
were
to
estimate
prevalence
and
risk
factors
for
preeclampsia
hospitalized
pregnant
women
with
COVID-19.
As
comparing
maternal
perinatal
outcomes
those
without
preeclampsia.
Methods
Prospective
cohort
100
from
two
tertiary
hospitals,
diagnosed
COVID-19,
divided
into
groups:
PE+
group
(pregnant
preeclampsia)
PE-
preeclampsia).
These
had
prevalence,
factors,
data
analyzed.
Results
was
11%.
Severe
factor
(OR
=
8.18
[CI
1.53–43.52]),
fetal
growth
restriction
outcome
8.90
1.52–38.4]).
Comorbidities
more
frequent
(63.6%
vs
31.5%,
p
0.03),
prematurity
(81.8%
41.6%,
0.02),
low
birth
weight
24.7%,
0.01),
need
neonatal
intensive
care
admission
newborn
27.0%,
0.03).
Pregnant
PE
twice
long
a
length
stay
unit
(RR
2.35
1.34–4.14]).
Although
mortality
among
PE,
it
not
statistically
significant.
Conclusions
Prevalence
associated
comorbidities
increased
developing
Long
Язык: Английский
MENSA, a Media Enriched with Newly Synthesized Antibodies, to Identify SARS-CoV-2 Persistence and Latent Viral Reactivation in Long-COVID
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Abstract
Post-acute
sequelae
of
SARS-CoV-2
(SARS2)
infection
(PASC)
is
a
heterogeneous
condition,
but
the
main
viral
drivers
are
unknown.
Here,
we
use
MENSA,
Media
Enriched
with
Newly
Synthesized
Antibodies,
secreted
exclusively
from
circulating
human
plasmablasts,
to
provide
an
immune
snapshot
that
defines
underlying
triggers.
We
proof-of-concept
testing
MENSA
technology
can
capture
new
host
response
accurately
diagnose
acute
primary
and
breakthrough
infections
when
known
SARS2
virus
or
proteins
present.
It
also
positive
after
vaccination
spike
elicit
response.
Applying
same
principles
for
long-COVID
patients,
in
40%
PASC
vs
none
COVID
recovered
(CR)
patients
without
any
demonstrating
ongoing
inflammation
only
PASC.
Additionally,
MENSAs
Epstein-Barr
Virus
(EBV)
37%,
Human
Cytomegalovirus
(CMV)
23%,
herpes
simplex
2
(HSV2)
15%
compared
17%,
4%,
4%
CR
controls
respectively.
Combined,
total
60%
have
SARS2,
EBV,
CMV,
and/or
HSV2.
offers
unique
antibody
reveal
thus
persistence
reactivation
patients.
Язык: Английский
COVID-19 and Neurodegenerative Diseases: One Health Approach
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
SARS-CoV-2,
the
causative
agent
of
COVID-19,
was
identified
in
late
2019
and
subsequently
transmitted
globally.
COVID-19
has
caused
substantial
risk
to
public
health
safety,
with
a
marked
increase
both
mortality
morbidity.
Due
high
transmission
multifactorial
pathogenesis
patients
have
reported
several
long-term
complications,
including
impaired
pulmonary
function,
fatigue,
neurological
manifestations,
kidney
injury.
Recent
studies
demonstrated
that
SARS-CoV-2
can
breach
blood-brain
barrier
trigger
hyperphosphorylation
tau
protein
accumulation
beta-amyloid
synuclein
protein,
which
increases
progression
Alzheimer’s,
Parkinson’s,
other
neurodegenerative
diseases
(NDs)
elderly
population.
One
Health
approach
is
required
combat
this
complication,
may
be
defined
as
an
interdisciplinary
strategy
recognizes
relationship
between
animals,
humans,
environment
achieve
optimal
health.
In
addition,
might
support
researchers
study
NDs.
The
distinctive
impact
on
system
should
considered
while
envisaging
prospective
“One
Health”
programs
related
COVID-19.
Therefore,
chapter
summarizes
NDs
significance
management
effect
mental
Язык: Английский