Diffusion- and Tractography-Based Characterization of Tissue Damage Within and Surrounding Paramagnetic Rim Lesions in Multiple Sclerosis DOI
Maryam Mohebbi, Jack A. Reeves, Dejan Jakimovski

и другие.

American Journal of Neuroradiology, Год журнала: 2025, Номер 46(3), С. 611 - 619

Опубликована: Март 1, 2025

Paramagnetic rim lesions (PRLs) are an imaging biomarker of chronic inflammation in MS that associated with more aggressive disease. However, the precise tissue characteristics and extent their damage, particularly regard to connected axonal tracts, incompletely understood. Quantitative diffusion measurements fiber tractography can provide a complete picture these phenomena. One hundred fifteen people were enrolled this study. susceptibility mapping DWI acquired on 3T MRI scanner. PRLs identified 49 (43%) subjects. Diffusion was then used identify nearby PRL-connected versus non-PRL tracts nonconnected surrounding tracts. metrics, including fractional anisotropy (FA), quantitative (QA), mean diffusivity, axial radial isotropy, restricted imaging, compared between within themselves. Tissue had significantly lower FA than T2 (P = .04). Tracts exhibited < .001), higher .02, Iso values .007) lesions. Only QA different .003). destructive both themselves tissue. This damage appears spatially axonally mediated.

Язык: Английский

Smouldering‐Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions DOI Creative Commons
Antonio Scalfari, Anthony Traboulsee, Jiwon Oh

и другие.

Annals of Neurology, Год журнала: 2024, Номер 96(5), С. 826 - 845

Опубликована: Июль 25, 2024

Despite therapeutic suppression of relapses, multiple sclerosis (MS) patients often experience subtle deterioration, which extends beyond the definition "progression independent relapsing activity." We propose concept smouldering-associated-worsening (SAW), encompassing physical and cognitive symptoms, resulting from smouldering pathological processes, remain unmet targets. provide a consensus-based framework possible substrates manifestations MS, we discuss clinical, radiological, serum/cerebrospinal fluid biomarkers for potentially monitoring SAW. Finally, share considerations optimizing disease surveillance implications clinical trials to promote integration MS into routine practice future research efforts. ANN NEUROL 2024;96:826-845.

Язык: Английский

Процитировано

22
Safety and efficacy of evobrutinib in relapsing multiple sclerosis (evolutionRMS1 and evolutionRMS2): two multicentre, randomised, double-blind, active-controlled, phase 3 trials DOI
Xavier Montalbán, Patrick Vermersch, Douglas L. Arnold

и другие.

The Lancet Neurology, Год журнала: 2024, Номер 23(11), С. 1119 - 1132

Опубликована: Сен. 20, 2024

Язык: Английский

Процитировано

22
TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis DOI Creative Commons
Ceren Tozlu, Keith Jamison, Yeona Kang

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Abstract Objective To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation PRL-disrupted WM associated with disability people multiple sclerosis (MS). Methods Forty-four MS patients 16 healthy controls were included. 18 kDa-translocator protein positron emission tomography (TSPO-PET) 11 C-PK11195 radioligand was used to measure neuroinflammatory activity. The Network Modification Tool identify PRLs non-PRLs that delineated on MRI. Expanded Disability Status Scale disability. Results had whole brain compared (p=0.001). Compared without PRLs, exhibited levels of any type (p=0.02) or (p=0.004). In at least one PRL, highly (p=0.009). Elevated increased PRL (p=0.03), but not (p=0.2). Interpretation This study suggests may exhibit more diffuse addition along non-PRLs, which could contribute larger lesion volumes faster progression. Imaging serve both focal inflammation, guiding therapeutic interventions aimed reducing preventing progressive MS.

Язык: Английский

Процитировано

3
Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis DOI Creative Commons
Serena Borrelli, Maria Sofia Martire, Anna Stölting

и другие.

Neurology Neuroimmunology & Neuroinflammation, Год журнала: 2024, Номер 11(4)

Опубликована: Май 24, 2024

The diagnosis of multiple sclerosis (MS) can be challenging in clinical practice because MS presentation atypical and mimicked by other diseases. We evaluated the diagnostic performance, alone or combination, central vein sign (CVS), paramagnetic rim lesion (PRL), cortical (CL), as well their association with outcomes.

Язык: Английский

Процитировано

12
Associations Between Paramagnetic Rim Lesion Evolution and Clinical and Radiologic Disease Progression in Persons With Multiple Sclerosis DOI
Jack A. Reeves, Alexander Bartnik, Dejan Jakimovski

и другие.

Neurology, Год журнала: 2024, Номер 103(10)

Опубликована: Окт. 24, 2024

Recent technological advances have enabled visualizing in vivo a subset of chronic active brain lesions persons with multiple sclerosis (pwMS), referred to as "paramagnetic rim lesions" (PRLs), iron-sensitive MRI. PRLs predict future clinical disease progression, making them promising and translational imaging marker. However, it is unknown how progression modified by PRL evolution (PRL disappearance, new appearance). This key understanding MS pathophysiology may help inform selection sensitive endpoints for trials targeting inflammation. To this end, we assessed the longitudinal associations between disappearance appearance disability atrophy.

Язык: Английский

Процитировано

10
Towards a biological view of multiple sclerosis from early subtle to clinical progression: an expert opinion DOI Creative Commons
Massimo Filippi, Maria Pia Amato, Carlo Avolio

и другие.

Journal of Neurology, Год журнала: 2025, Номер 272(2)

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Age Matters in Multiple Sclerosis DOI
Maria A. Rocca, Paolo Preziosa, Massimo Filippi

и другие.

Neurology, Год журнала: 2025, Номер 104(4)

Опубликована: Фев. 4, 2025

Язык: Английский

Процитировано

1
Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis DOI Creative Commons

Riccardo Nistri,

Antonio Ianniello, Valeria Pozzilli

и другие.

Diagnostics, Год журнала: 2024, Номер 14(11), С. 1120 - 1120

Опубликована: Май 28, 2024

Brain and spinal cord imaging plays a pivotal role in aiding clinicians with the diagnosis monitoring of multiple sclerosis. Nevertheless, significance magnetic resonance MS extends beyond its clinical utility. Advanced modalities have facilitated vivo detection various components pathogenesis, and, recent years, MRI biomarkers been utilized to assess response patients relapsing-remitting available treatments. Similarly, indicators neurodegeneration demonstrate potential as primary secondary endpoints trials targeting progressive phenotypes. This review aims provide an overview latest advancements brain neuroimaging MS.

Язык: Английский

Процитировано

6
Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis DOI Creative Commons
Sienna Drake, Aliyah Zaman,

Christine Gianfelice

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Ноя. 1, 2024

The role of senescence in disease contexts is complex, however there considerable evidence that depletion senescent cells improves outcomes a variety particularly related to aging, cognition, and neurodegeneration. Much research has shown previously inflammation can promote cellular senescence. Microglia are central nervous system innate immune cell undergo with aging during contribution microglia multiple sclerosis, an inflammatory neurodegenerative disease, not clear, but strongly implicated chronic active lesion pathology, tissue injury, progression. Drugs could specifically eliminate dysregulated sclerosis therefore great interest the field.

Язык: Английский

Процитировано

6
Chronic active lesions in multiple sclerosis: classification, terminology, and clinical significance DOI Creative Commons
Assunta Dal‐Bianco, Jiwon Oh, Pascal Sati

и другие.

Therapeutic Advances in Neurological Disorders, Год журнала: 2024, Номер 17

Опубликована: Янв. 1, 2024

In multiple sclerosis (MS), increasing disability is considered to occur due persistent, chronic inflammation trapped within the central nervous system (CNS). This condition, known as smoldering neuroinflammation, present across clinical spectrum of MS and currently understood be relatively resistant treatment with existing disease-modifying therapies. Chronic active white matter lesions represent a key component neuroinflammation. Initially characterized in autopsy specimens, approaches visualize (CALs) vivo using advanced neuroimaging techniques postprocessing methods are rapidly emerging. Among these imaging correlates CALs, paramagnetic rim (PRLs) defined by presence perilesional formed iron-laden microglia macrophages, whereas slowly expanding identified based on linear, concentric lesion expansion over time. recent years, several longitudinal studies have linked occurrence detected CALs more aggressive disease course. PRLs highly specific therefore recently been incorporated into diagnostic criteria. They also prognostic potential biomarkers identify patients at risk early severe progression. These developments could significantly affect care evaluation new treatments. review describes latest knowledge CAL biology relevance natural history MS. addition, we outline considerations for current future emphasizing need validation, standardization, automation their assessment.

Язык: Английский

Процитировано

6