White matter lesion volumes on 3-T MRI in people with MS who had followed a diet- and lifestyle program for more than 10 years DOI Open Access
Mariaan Jaftha, Frances Robertson, Susan J. van Rensburg

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 6, 2024

Abstract Background Cerebral white matter lesions (WMLs) in people with multiple sclerosis (pwMS) are associated the death of myelin-producing oligodendrocytes. MS treatment strategies aim to limit WML accumulation and disability progression. It is commonly accepted that nutrition one possible environmental factors involved pathogenesis MS, but its role as a complementary unclear and, large extent, ignored. Objective A pilot case control study over 10 year period ascertain whether dietary- lifestyle modification Program pwMS reduces or prevents formation. Methods MRI was performed at baseline after an interval least years longer 22 pwMS. volumes were determined using Sequence Adaptive Multimodal SEGmentation (SAMSEG) software, part FreeSurfer 7.2. Other variables include age MRI, disease duration, status medication. Results PwMS (n=13) who had followed for more than years, significantly smaller lesion (mm 3 ) compared did not adhere (n=9) (4950 ± 5303 vs 17934 11139; p=0.002). (p=0.02) (EDSS) (p=0.350), duration (p=0.709), Interferon-β (p=0.70). Conclusion Dietary- changes may lower risk developing cerebral WMLs potentially slow down Larger studies required confirm effectiveness such interventions

Язык: Английский

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis DOI
Éric Thouvenot, David Laplaud,

Christine Lebrun-Frenay

и другие.

JAMA, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Importance Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and associated with the of disease activity, but data on benefits supplementation are conflicting. Objective To evaluate efficacy high-dose cholecalciferol as monotherapy in reducing activity patients clinically isolated syndrome (CIS) typical MS. Design, Setting, Participants The D-Lay MS trial was parallel, double-blind, randomized placebo-controlled clinical 36 centers France. Patients were enrolled from July 2013 to December 2020 (final follow-up January 18, 2023). Untreated CIS aged 18 55 years duration less than 90 days, serum vitamin concentration 100 nmol/L, diagnostic magnetic resonance imaging (MRI) meeting 2010 criteria dissemination space or 2 more lesions presence oligoclonal bands recruited. Intervention 1:1 receive oral 000 IU (n = 163) placebo 153) every weeks 24 months. Main Outcomes Measures primary outcome measure defined occurrence relapse and/or MRI (new contrast-enhancing lesions) over months follow-up, also analyzed separate secondary outcomes. Results Of 316 participants (median [IQR] age, 34 [28-42] years; 70% women), analysis included 303 (95.9%) who took at least 1 dose study drug 288 (91.1%) ultimately completed 24-month trial. Disease observed 94 (60.3%) group 109 (74.1%) (hazard ratio [HR], 0.66 [95% CI, 0.50-0.87]; P .004), median time longer (432 vs 224 days; log-rank .003). All 3 outcomes reported significant differences favoring group: (89 [57.1%] 96 [65.3%]; HR, 0.71 0.53-0.95]; .02), new (72 [46.2%] 87 [59.2%]; 0.61 0.44-0.84]; .003), (29 [18.6%] 50 [34.0%]; 0.47 0.30-0.75]; .001). 10 showed no difference, including relapse, which occurred 28 (17.9%) 32 (21.8%) (HR, 0.69 0.42-1.16]; .16). similar subset 247 updated 2017 relapsing-remitting treatment initiation. Severe adverse events 17 13 group, none related cholecalciferol. Conclusions Relevance Oral significantly reduced early These results warrant further investigation, potential role pulse add-on therapy. Trial Registration ClinicalTrials.gov Identifier: NCT01817166

Язык: Английский

Процитировано

4
How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases? DOI Open Access
Daniela Gallo, Denisa Baci, Nataša Kuštrimović

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4689 - 4689

Опубликована: Фев. 28, 2023

Vitamin D is a secosteroid hormone that highly involved in bone health. Mounting evidence revealed that, addition to the regulation of mineral metabolism, vitamin implicated cell proliferation and differentiation, vascular muscular functions, metabolic Since discovery receptors T cells, local production active was demonstrated most immune addressing interest clinical implications status surveillance against infections autoimmune/inflammatory diseases. together with B are seen as main cells autoimmune diseases; however, growing currently focused on innate compartment, such monocytes, macrophages, dendritic natural killer initiation phases autoimmunity. Here we reviewed recent advances onset Graves’ Hashimoto’s thyroiditis, vitiligo, multiple sclerosis relation role their crosstalk acquired cells.

Язык: Английский

Процитировано

39
The Role of Vitamin D in Neuroprotection in Multiple Sclerosis: An Update DOI Open Access

Amarpreet Sangha,

Michaela Quon,

Gerald Pfeffer

и другие.

Nutrients, Год журнала: 2023, Номер 15(13), С. 2978 - 2978

Опубликована: Июнь 30, 2023

Multiple sclerosis (MS) is a complex neurological condition that involves both inflammatory demyelinating and neurodegenerative components. MS research treatments have traditionally focused on immunomodulation, with less investigation of neuroprotection, this holds true for the role vitamin D in MS. Researchers already established plays an anti-inflammatory modulating immune system More recently, researchers begun investigating potential neuroprotective The active form D, 1,25(OH)2D3, has range properties, which may be important remyelination and/or prevention demyelination. most notable finding relevant to 1,25(OH)2D3 promotes stem cell proliferation drives differentiation neural cells into oligodendrocytes, carry out remyelination. In addition, counteracts neurodegeneration oxidative stress by suppressing activation reactive astrocytes M1 microglia. also expression various factors, including neurotrophins antioxidant enzymes. decreases blood–brain barrier permeability, reducing leukocyte recruitment central nervous system. These effects, stimulated all enhance neuronal survival. This review summarizes connects current evidence supporting D-mediated mechanisms action neuroprotection

Язык: Английский

Процитировано

28
Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection DOI Creative Commons
Anna Karin Hedström

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июль 24, 2023

Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from complex interplay between latent EBV infection, genetic predisposition, and various environmental lifestyle factors negatively affect immune control of the infection. Evidence gene-environment interactions epigenetic modifications triggered by in genetically susceptible individuals supports this view. This review gives short introduction to host immunity discusses indicating as MS. role risk factors, their interactions, MS pathogenesis reviewed put context Finally, possible preventive measures are discussed based on findings presented.

Язык: Английский

Процитировано

27
Vitamin D Supplementation: Effect on Cytokine Profile in Multiple Sclerosis DOI Open Access
Maddalena Sparaco, Simona Bonavita

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(3), С. 835 - 835

Опубликована: Фев. 1, 2024

Vitamin D is known for its role in modulating calcium and phosphate homeostasis implicated both bone mineralization immune system regulation. The immune-modulatory of vitamin impact on multiple sclerosis (MS) courses are still debated. aim this review was to check the effect supplementation cytokine profile regulation people with MS. A significant increase serum concentrations interleukin (IL)-10 Transforming growth factor (TGF)-β1 after demonstrated most studies, some them reporting a reduction disability scores an inverse correlation between IL-10 levels disability. IL-17 IL-6 controversial; different results across studies could be explained by variability treatment duration, route, frequency administration, as well dosage supplementation, responses reached including methods used analysis cell types investigated, MS phenotype, disease phase (active vs. non-active) concomitant disease-modifying therapies. Nevertheless, TGF-β1, suggests anti-inflammatory supplementation.

Язык: Английский

Процитировано

8
Vitamin D and ischemic stroke - Association, mechanisms, and therapeutics DOI
Pan Cui,

Haiman Hou,

Bo Song

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 96, С. 102244 - 102244

Опубликована: Фев. 21, 2024

Язык: Английский

Процитировано

8
Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes DOI Creative Commons
Eleftheria Kodosaki, William J. Watkins,

Sam Loveless

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Фев. 17, 2024

Abstract Establishing biomarkers to predict multiple sclerosis diagnosis and prognosis has been challenging using a single biomarker approach. We hypothesised that combination of would increase the accuracy prediction models differentiate from other neurological disorders enhance prognostication for people with sclerosis. measured 24 fluid in blood cerebrospinal 77 80 disorders, ELISA or Single Molecule Array assays. Primary outcomes were versus any diagnosis, time first relapse, disability milestone (Expanded Disability Status Scale 6), adjusted age sex. Multivariate calculated area under curve value diagnostic prediction, concordance statistics (the percentage each pair events are correctly ordered Cox regression models) prognostic predictions. Predictions combinations considerably better than The [chitinase-3-like-1 + TNF-receptor-1 CD27] serum [osteopontin MCP-1] had an 0.97 sclerosis, compared best discriminative marker (osteopontin: 0.84) (chitinase-3-like-1 0.84). Prediction next relapse was optimal fluid[vitamin D binding protein Factor I C1inhibitor] serum[Factor B Interleukin-4 (concordance 0.80), Expanded 6 [C9 Neurofilament-light] serum[chitinase-3-like-1 CCL27 vitamin 0.98). A higher significantly improved development sustained Serum rivalled those fluid, holding promise non-invasive utility our can only be established by robust validation different varied cohorts.

Язык: Английский

Процитировано

7
Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders DOI

Manjari Skv,

Sharon Mariam Abraham,

Omalur Eshwari

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер 61(9), С. 7211 - 7238

Опубликована: Фев. 19, 2024

Язык: Английский

Процитировано

7
Vitamin D3 as an add-on treatment for multiple sclerosis: A systematic review and meta-analysis of randomized controlled trials DOI
João Vitor Mahler,

Marina Solti,

Samira Luísa Apóstolos‐Pereira

и другие.

Multiple Sclerosis and Related Disorders, Год журнала: 2024, Номер 82, С. 105433 - 105433

Опубликована: Янв. 6, 2024

Язык: Английский

Процитировано

6
Calcitriol restrains microglial M1 polarization and alleviates dopaminergic degeneration in hemiparkinsonian mice by boosting regulatory T‐cell expansion DOI Creative Commons
Yangzhi Xie, Liang Chen, Jiacheng Chen

и другие.

Brain and Behavior, Год журнала: 2024, Номер 14(2)

Опубликована: Фев. 1, 2024

Abstract Objective Vitamin D deficiency is a risk factor for Parkinson's disease (PD) and vitamin supplementation robustly alleviates neurodegeneration in PD models. However, the mechanisms underlying this effect require further clarification. Current evidence suggests that harnessing regulatory T cells (Treg) may mitigate neuronal degeneration. In study, we investigated therapeutic effects of receptor activation by calcitriol on PD, specifically focusing its role Treg. Methods Hemiparkinsonian mice model was established through injection 6‐OHDA into striatum. Mice were pretreated with before injection. The motor performance, dopaminergic survival, contents dopamine, dopamine metabolites evaluated. pro‐inflammatory cytokines levels, T‐cell infiltration, mRNA expression indicated microglial M1/M2 phenotypic markers, marker midbrain detected. Populations Treg splenic tissues assessed using flow cytometry assay. PC61 monoclonal antibody applied to deplete vivo. Results We show notably improved performance reduced degeneration 6‐OHDA‐induced model. Mechanistically, promoted anti‐inflammatory/neuroprotective inhibited pro‐inflammatory/neurodestructive effector generation This process significantly infiltration midbrain, restrained activation, M1 polarization, decreased release. more favorable inflammatory microenvironment rescued To verify anti‐inflammatory are associated expansion, an antibody‐mediated depletion As predicted, diminished following depletion. Conclusion These findings suggest calcitriol's neuroprotective potential boost expansion.

Язык: Английский

Процитировано

6