Physical Medicine and Rehabilitation Clinics of North America, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Pathogens, Год журнала: 2024, Номер 13(5), С. 388 - 388
Опубликована: Май 8, 2024
The infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated not only with the development of disease but also long-term symptoms or post-acute sequelae SARS-CoV-2 (PASC). Multiple lines evidence support that some viral antigens and RNA can persist for up to 15 months in multiple organs body, often after apparent clearance from upper system, possibly leading persistence symptoms. Activation immune system observed a prolonged time, providing indirect elements infection. In gastrointestinal tract, could stimulate shaping local microbiota potential systemic effects. All these interactions need be investigated, taking into account predisposing factors, multiplicity pathogenic mechanisms, stratifying populations vulnerable individuals, particularly women, children, immunocompromised where may present additional challenges.
Язык: Английский
Процитировано
7
Otolaryngology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
To investigate the effectiveness of platelet-rich plasma (PRP) injection into olfactory clefts coronavirus disease 2019 (COVID-19) patients with persistent anosmia, hyposmia, and parosmia. Controlled study. Multicenter From March 2022 to July 2024, 514 COVID-19 undergoing PRP training versus (controls) for a dysfunction (OD) were consecutively recruited from two medical centers. Subjects evaluated pre- 3 months post-injection disorder questionnaire (ODQ) threshold, discrimination, identification (TDI) test. Olfactory outcomes compared between controls considering type OD (anosmia, parosmia). The group was composed 416 anosmia (N = 111; 26.7%), hyposmia 160; 38.5%), parosmia 145; 34.9%). baseline ODQ significantly higher than those other groups (P .001). increase in TDI subscores total score all subgroups 0.001). reduced post-PRP Patients showed greater reduction scores control group. 3-month negatively influenced by age (rs -0.263; P 0.001) duration -0.213; experienced stronger impact on quality life (QoL), QoL improvement following injections groups.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Heart & Lung, Год журнала: 2024, Номер 68, С. 373 - 380
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
3
iScience, Год журнала: 2024, Номер 27(10), С. 111027 - 111027
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
1
Viruses, Год журнала: 2024, Номер 16(9), С. 1369 - 1369
Опубликована: Авг. 28, 2024
The pathophysiological mechanisms of the post-acute sequelae COVID-19 (PASC) remain unclear. Sex differences not only exist in disease severity acute SARS-CoV-2 infection but also risk suffering from PASC. Women have a higher PASC and longer time to resolution than men. To explore possible immune among non-elderly females, we mined single-cell transcriptome data peripheral blood samples female patients with infection, together age- gender-matched non-PASC healthy controls available Gene Expression Omnibus database. By comparing differences, found that CD14+ monocyte subset characterized by expression signal transducers activators transcription 2 (STAT2) (CD14+STAT2high) was notably increased compared individuals. transcriptional factor (TF) activity analysis revealed STAT2 IRF9 were key TFs determining function CD14+STAT2high monocytes. are exclusively involving type I III interferon (IFN) signaling pathways, resulting uncontrolled IFN-I activation interferonopathy. Furthermore, common interferon-stimulated genes (ISGs) has been identified most subsets patients, including IFI6, IFITM3, IFI44L, IFI44, EPSTI1, ISG15, MX1. This study reveals featured associated activation, which is indicative interferonopathy
Язык: Английский
Процитировано
0
Entreciencias diálogos en la Sociedad del Conocimiento, Год журнала: 2024, Номер 12(26), С. 1 - 12
Опубликована: Ноя. 29, 2024
Propósito: evaluar la prevalencia de COVID prolongado (CP) en adultos mexicanos y su relación con factores sociodemográficos, epidemiológicos, estilo vida comportamiento socioemocional asociados a pandemia. Diseño metodológico: entre diciembre 2023 enero 2024, se llevó cabo una encuesta transversal línea el noroeste México, considerando solo quienes reportaron haber contraído COVID-19. Se analizaron diferencias presentaron o no síntomas CP (Chi-cuadrada) identificaron posibles predictores cp mediante un análisis regresión lineal múltiple jerárquica, que incluía epidemiológicos socioemocionales. Resultados: 52% los participantes presentó cp, gran variedad síntomas, principalmente mujeres (70%). observaron significativas función severidad infección (p=.021), encontró asociación probabilidad desarrollar dependiendo del sexo edad, acuerdo infección, presencia comorbilidades, disminución actividad física socioemocional. Limitaciones investigación: método recolección datos puede excluido subrepresentado las personas sin acceso internet, medidas autoinformadas carecen validación. Hallazgos: es alta población estudiada, ocurrencia está relacionada contagio inicial número persistentes, independientemente sexo; siendo más probable hombres mediana comorbilidades preexistentes moderada.
Процитировано
0
Physical Medicine and Rehabilitation Clinics of North America, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0