Mağallaẗ zirāʿaẗ al-rāfidayn,
Год журнала:
2023,
Номер
51(4), С. 81 - 68
Опубликована: Дек. 1, 2023
The
purpose
of
this
study
was
to
evaluate
the
impact
adding
postbiotics
produced
from
two
species
lactic
acid
bacteria,
Lactobacillus
acidophilus
(Lap)
and
Lactiplantibacillus
plantarum
(Lpp),
broiler
chicken
diets
on
their
productivity,
gastrointestinal
microbiota
count,
nutrient
digestibility.
Using
a
completely
randomized
design,
315
one-day-old
chicks
(Ross-
308)
were
randomly
divided
into
seven
groups
three
replications,
with
fifteen
unsexed
per
replicate.
basal
diet
administered
without
supplements
(negative
control)
or
supplemented
Tetracycline
(TET)
at
0.02%
(positive
control).
other
five
groups:
T1,
T2
(basal
Lap
0.25%,
0.50%
respectively);
T3,
T4
Lpp
T5,
0.25%
+
Lpp).Results
indicated
that
feeding
chickens
(excluding
T1)
positive
control
resulted
in
significant
improvements
(P≤0.05)
body
weight
gain,
feed
intake,
conversion
ratio,
production
index,
economic
efficiency
compared
negative
group.
Also
showed
highest
level
Lactobacilli
count
jejunum,
lowest
E.
coli
bacteria
decreased
significantly
all
control.
Additionally,
TET
treatments
improved
digestibility
dry
matter,
protein,
fat,
protein
ratio
passage
rate
results
suggest
can
enhance
growth
performance,
digestibility,
efficiency,
rate,
intestinal
chickens.
The
gut
microbiota
is
a
complex
ecosystem
that
plays
critical
role
in
human
health
and
disease.
However,
the
relationship
between
intestinal
damage
caused
by
burns
not
well
understood.
mucus
layer
crucial
for
maintaining
homeostasis
providing
physiological
barrier
against
bacterial
invasion.
This
study
aims
to
investigate
impact
of
on
synthesis
degradation
after
explore
potential
therapeutic
targets
burn
injury.
A
modified
histopathological
grading
system
was
employed
effects
injury
colon
tissue
mice.
Subsequently,
16S
ribosomal
RNA
sequencing
used
analyze
alterations
at
days
1-10
post-burn.
Based
this,
metagenomic
conducted
samples
collected
1,
5
10
changes
mucus-related
underlying
mechanisms.
Our
findings
showed
disrupted
translocation
occurred
day
3
following
Moreover,
mice
significantly
from
1
injury,
but
gradually
recovered
normal
as
disease
progressed.
Specifically,
there
marked
increase
abundance
symbiotic
pathogenic
bacteria
associated
with
mucin
burns,
returned
5.
Conversely,
probiotic
changed
opposite
direction.
Further
analysis
revealed
capable
degrading
may
utilize
glycoside
hydrolases,
flagella
internalins
break
down
layer,
while
synthesize
help
restore
promoting
production
short-chain
fatty
acids.
Burn
leads
disruption
colonic
dysbiosis
microbiota.
Some
commensal
participate
via
flagella,
internalins,
etc.
Probiotics
provide
acids
(particularly
butyrate)
an
energy
source
stressed
epithelial
cells,
promote
accelerate
repair
layer.
Medicina,
Год журнала:
2024,
Номер
60(6), С. 934 - 934
Опубликована: Июнь 3, 2024
I
propose
that
a
deficiency
of
essential
fatty
acids
(EFAs)
and
an
alteration
in
their
metabolism
could
be
major
factor
the
pathogenesis
sepsis
sepsis-related
mortality.
The
failure
corticosteroids,
anti-TNF-α,
anti-interleukin-6
monoclonal
antibodies
can
attributed
to
this
altered
EFA
sepsis.
Vitamin
C;
folic
acid;
vitamin
B1,
B6,
B12
serve
as
co-factors
necessary
for
activity
desaturase
enzymes
are
rate-limiting
steps
EFAs.
EFAs
results
imbalance
production
activities
pro-
anti-inflammatory
eicosanoids
cytokines
resulting
both
hyperimmune
hypoimmune
responses
seen
This
implies
restoring
normal
may
form
newer
therapeutic
approach
prevention
management
other
critical
illnesses.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(20), С. 6082 - 6082
Опубликована: Окт. 12, 2024
Sepsis
is
a
complex
clinical
syndrome
characterized
by
an
uncontrolled
inflammatory
response
to
infection
that
may
result
in
septic
shock
and
death.
Recent
research
has
revealed
crucial
link
between
sepsis
alterations
the
gut
microbiota,
showing
microbiome
could
serve
essential
function
its
pathogenesis
prognosis.
In
sepsis,
microbiota
undergoes
significant
dysbiosis,
transitioning
from
beneficial
commensal
flora
predominance
of
pathobionts.
This
transformation
can
lead
dysfunction
intestinal
barrier,
compromising
host's
immune
response,
which
contributes
severity
disease.
The
intricate
system
protozoa,
fungi,
bacteria,
viruses
are
for
maintaining
immunity
metabolic
balance.
there
reduction
microbial
heterogeneity
pathogenic
such
as
proteobacteria,
exacerbate
inflammation
negatively
influence
outcomes.
Microbial
compounds,
short-chain
fatty
acids
(SCFAs),
perform
task
modulating
barrier
function.
However,
role
other
components,
remains
unclear.
Innovative
therapeutic
strategies
aim
modulate
improve
management
sepsis.
These
include
selective
digestive
decontamination
(SDD),
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation
(FMT),
all
have
shown
potential,
although
variable,
results.
future
benefit
greatly
personalized
treatment
based
on
microbiota.
Rapid
easy-to-implement
tests
assess
profiles
metabolites
associated
with
revolutionize
disease's
diagnosis
management.
approaches
not
only
patient
prognosis
but
also
reduce
dependence
antibiotic
therapies
promote
more
targeted
sustainable
strategies.
Nevertheless,
still
limited
clarity
regarding
ideal
composition
should
be
further
near
future.
Similarly,
benefits
validated
through
additional
studies.
BMC Molecular and Cell Biology,
Год журнала:
2024,
Номер
25(1)
Опубликована: Апрель 23, 2024
Abstract
Background
Sepsis-induced
small-intestinal
injury
is
associated
with
increased
morbidity
and
mortality.
Our
previous
study
other
papers
have
shown
that
HIF-1α
has
a
protective
effect
on
intestinal
mucosal
in
septic
rats.
The
purpose
of
this
to
further
verify
the
mucosa
its
molecular
mechanism
vitro
experiments.
Methods
Caco-2
cells
were
selected
experiment
was
divided
into
2
parts.
Part
I:
activator
inhibitor
used
treat
lipopolysacchrides
(LPS)-stimulated
respectively,
explore
LPS
induced
cell
epithelial
model;
II:
mTOR
or
combined
without
activator,
LPS-stimulated
then
reducing
model
damage
detected.
Results
results
showed
decreased
permeability
up
regulated
tight
junction
(TJ)
expression,
while
had
opposite
activator.
activation
increased,
inhibition
protein
expression
downstream
target
molecules,
which
can
be
attenuated
by
inhibitor.
Conclusion
This
once
again
confirmed
alleviates
LPS-induced
through
P70S6K
signalling
pathway.
It
great
value
whether
HIF-2α
plays
crucial
roles
regulation
functions
future.
Journal of Current Science and Technology,
Год журнала:
2024,
Номер
14(2)
Опубликована: Май 2, 2024
Several
bacterial
genera,
including
Lactobacillus,
have
been
evaluated
for
their
beneficial
effects
in
humans.
This
study
aimed
to
evaluate
the
“probiotic”
and
“postbiotic”
potential
of
three
strains:
Lactobacillus
oris
RCEID28-3,
Limosilactobacillus
fermentum
RCEID23-2,
RCEID47-7.
Probiotics
are
defined
as
live
cells,
whereas
postbiotics
inactivated
or
killed
probiotics.
Probiotic
was
by
assessing
adhesion
ability
Caco-2
HT-29
cell
lines,
immunomodulatory
effects,
cholesterol
assimilation.
Meanwhile,
postbiotic
assessed
evaluating
through
measuring
cytokine
production
human
peripheral
blood
mononuclear
cells
(PBMCs)
using
an
enzyme-linked
immunosorbent
assay
(ELISA).
The
intestinal
showed
that
all
strains
exhibited
more
than
90%
both
except
L.
RCEID28-3.
highest
level
observed
revealed
probiotic
stimulated
cytokines:
IL-10,
IFN-
γ,
TNF-α,
PBMCs
with
different
cytokines,
indicating
strain-dependent
property.
Moreover,
assimilation
probiotics
strains,
especially
RCEID47-7,
could
reduce
levels.
Therefore,
this
provides
scientific
evidence
support
possibility
applying
forms
(postbiotics)
humans
near
future.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 22, 2024
Citation:
Mbalaviele
G
and
Ryffel
B
(2024)
Editorial:
Inflammasomes
in
human
diseases
metabolism.
Front.
Immunol.
15:1420303.
doi:
10.3389/fimmu.2024.1420303
Mağallaẗ zirāʿaẗ al-rāfidayn,
Год журнала:
2023,
Номер
51(4), С. 81 - 68
Опубликована: Дек. 1, 2023
The
purpose
of
this
study
was
to
evaluate
the
impact
adding
postbiotics
produced
from
two
species
lactic
acid
bacteria,
Lactobacillus
acidophilus
(Lap)
and
Lactiplantibacillus
plantarum
(Lpp),
broiler
chicken
diets
on
their
productivity,
gastrointestinal
microbiota
count,
nutrient
digestibility.
Using
a
completely
randomized
design,
315
one-day-old
chicks
(Ross-
308)
were
randomly
divided
into
seven
groups
three
replications,
with
fifteen
unsexed
per
replicate.
basal
diet
administered
without
supplements
(negative
control)
or
supplemented
Tetracycline
(TET)
at
0.02%
(positive
control).
other
five
groups:
T1,
T2
(basal
Lap
0.25%,
0.50%
respectively);
T3,
T4
Lpp
T5,
0.25%
+
Lpp).Results
indicated
that
feeding
chickens
(excluding
T1)
positive
control
resulted
in
significant
improvements
(P≤0.05)
body
weight
gain,
feed
intake,
conversion
ratio,
production
index,
economic
efficiency
compared
negative
group.
Also
showed
highest
level
Lactobacilli
count
jejunum,
lowest
E.
coli
bacteria
decreased
significantly
all
control.
Additionally,
TET
treatments
improved
digestibility
dry
matter,
protein,
fat,
protein
ratio
passage
rate
results
suggest
can
enhance
growth
performance,
digestibility,
efficiency,
rate,
intestinal
chickens.
