Pilot study of optical coherence tomography angiography-derived microvascular metrics in hands and feet of healthy and diabetic people DOI Creative Commons
Gavrielle R. Untracht, Νικόλαος Δικαίος,

Abdullah K. Durrani

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Янв. 20, 2023

Abstract Optical coherence tomography angiography (OCTA) is a non-invasive, high-resolution imaging modality with growing application in dermatology and microvascular assessment. Accepted reference values for OCTA-derived parameters skin do not yet exist but need to be established drive OCTA into the clinic. In this pilot study, we assess range of metrics at rest after post-occlusive reactive hyperaemia (PORH) hands feet 52 healthy people 11 well-controlled type 2 diabetes mellitus (T2DM). We calculate each metric, measure test–retest repeatability, evaluate correlation demographic risk factors. Our study delivers extremity-specific, age-dependent coefficients repeatability nine baseline maximum PORH. Significant differences are seen hand, they present several foot. observed between hand foot, both PORH, most generally higher hand. Despite large variability over individuals, as expected based on heterogeneous ageing phenotypes population, 3.5% 18% mean value all metrics, which highlights opportunities OCTA-based studies larger cohorts, longitudinal monitoring, assessing efficacy interventions. Additionally, branchpoint density foot changes vessel diameter response PORH stood out good discriminators T2DM groups, indicates their potential biomarkers. This building our previous work, represents further step towards standardised clinical practice research.

Язык: Английский

Vascular ageing: moving from bench towards bedside DOI Creative Commons
Rachel E. Climie, Jordi Alastruey, Christopher Mayer

и другие.

European Journal of Preventive Cardiology, Год журнала: 2023, Номер 30(11), С. 1101 - 1117

Опубликована: Фев. 4, 2023

Abstract Prevention of cardiovascular disease (CVD) remains one the largest public health challenges our time. Identifying individuals at increased risk an asymptomatic, sub-clinical stage is paramount importance for minimizing progression as well substantial and economic burden associated with overt CVD. Vascular ageing (VA) involves deterioration in vascular structure function over time ultimately leads to damage heart, brain, kidney, other organs. encompasses cumulative effect all factors on arterial wall life course thus may help identify those elevated risk, early development. Although concept VA gaining interest clinically, it seldom measured routine clinical practice due lack consensus how characterize physiological vs. pathological various practical issues. In this state-of-the-art review a network scientists, clinicians, engineers, industry partners expertise VA, we address six questions related attempt increase knowledge among broader medical community move measurement little closer from bench towards bedside.

Язык: Английский

Процитировано

67
Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial DOI Creative Commons

Eleanor Wood,

Sabine Hein,

Robin Mesnage

и другие.

American Journal of Clinical Nutrition, Год журнала: 2023, Номер 117(6), С. 1306 - 1319

Опубликована: Март 25, 2023

Язык: Английский

Процитировано

44
Bovine dairy products and flow mediated dilation (FMD): a systematic review of the published evidence DOI Creative Commons
M. L. Rooney,

Joyce Lambe,

Aileen O’Connor

и другие.

European Journal of Nutrition, Год журнала: 2025, Номер 64(2)

Опубликована: Янв. 24, 2025

Abstract Purpose Evidence suggests bovine dairy products may have neutral or beneficial effects on cardiometabolic health, despite being a source of saturated fat. The matrix, the structure and combination protein, fat, other nutrients, how they interact with each other, is purported to be responsible for these health effects. Whether this relationship extends endothelial function, as assessed by flow mediated dilation (FMD), remains elucidated. Methods Three electronic databases (PubMed, Embase Cochrane Central) were searched from inception until 5th September 2024. This review included randomised controlled trials (RCT) investigating any intervention which considered function using FMD in humans non-dairy alternative control. Results Of 4,220 records identified, 18 reports 11 RCT including 508 (53.3% male) participants, examined eligible evidence synthesis. Eight papers reported an improvement, nine no effect one decrease FMD. greatest found those impaired at baseline, whey protein high intakes observed most beneficial. Conclusion Bovine intake has health. demonstrates that Whey effective, although further quality area are warranted.

Язык: Английский

Процитировано

2
Consuming Pecans as a Snack Improves Lipids/Lipoproteins and Diet Quality Compared to Usual Diet in Adults at Increased Risk for Cardiometabolic Diseases: A Randomized Controlled Trial DOI Creative Commons
Tricia Hart, Penny M. Kris‐Etherton, Kristina Petersen

и другие.

American Journal of Clinical Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Advancements in risk stratification and management strategies in primary cardiovascular prevention DOI
Fotios Barkas, Yusuf Ziya Şener,

Pelin Golforoush

и другие.

Atherosclerosis, Год журнала: 2024, Номер 395, С. 117579 - 117579

Опубликована: Май 15, 2024

Язык: Английский

Процитировано

14
The long-term and post-prandial effects of berry consumption on endothelial dysfunction in adults: a systematic review and meta-analysis of randomised controlled trials DOI

Shokoofeh Talebi,

Mahsa Shirani, Nafiseh Shokri Mashhadi

и другие.

International Journal of Food Sciences and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 31

Опубликована: Янв. 19, 2025

This systematic review and meta-analysis evaluated the long-term post-prandial effects of berry consumption on endothelial dysfunction (ED) in adults. To identify relevant randomised controlled trials (RCTs), a search was run studies that examined berries ED markers were included. A total 45 RCTs included, focusing such as flow-mediated dilation (FMD), pulse wave velocity (PWV), augmentation index (AIx), reactive hyperaemia (RHI) peripheral resistance (TPR). The revealed significantly increased FMD decreased PWV. However, no significant found for AIx, RHI or TPR. In studies, also improved FMD, but had impact PWV, AIx RHI. Overall, to benefit function, particularly improving though other cardiovascular less consistent. Factors like trial design type influenced outcomes.

Язык: Английский

Процитировано

1
Clinical assessment of endothelial function in convalescent COVID-19 patients: a meta-analysis with meta-regressions DOI Creative Commons
Pasquale Ambrosino, Stefano Sanduzzi Zamparelli,

Marco Mosella

и другие.

Annals of Medicine, Год журнала: 2022, Номер 54(1), С. 3233 - 3248

Опубликована: Ноя. 16, 2022

Endothelial dysfunction has been proposed to play a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its post-acute sequelae. Flow-mediated dilation (FMD) is recognized as an accurate clinical method assess endothelial function. Thus, we performed meta-analysis studies evaluating FMD convalescent COVID-19 patients controls with no history COVID-19.A systematic literature search was conducted main scientific databases according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Using random effects method, differences between cases were expressed mean difference (MD) 95% confidence intervals (95% CI). The protocol registered on PROSPERO reference number CRD42021289684.Twelve included final analysis. A total 644 showed significantly lower values compared 662 (MD: -2.31%; CI: -3.19, -1.44; p < 0.0001). Similar results obtained sensitivity analysis that involved participants either group cardiovascular risk factors or coronary artery -1.73%; -3.04, -0.41; = 0.010). Interestingly, when considering separately based enrolment within after 3 months symptom onset, further confirmed both short- -2.20%; -3.35, -1.05; 0.0001) long-term follow-up -2.53%; -4.19, -0.86; 0.003). Meta-regression models increasing prevalence sequelae linked higher (Z-score: -2.09; 0.037).Impaired function can be documented patients, especially residual manifestations persist. Targeting through pharmacological rehabilitation strategies may represent attractive therapeutic option.Key messagesThe mechanisms underlying have not fully elucidated.Impaired up 1 year infection, persist.Targeting option phase COVID-19.

Язык: Английский

Процитировано

27
Associations between neurovascular coupling and cerebral small vessel disease: A systematic review and meta-analysis DOI Creative Commons
Sheng Yang, Alastair J.S. Webb

European Stroke Journal, Год журнала: 2023, Номер 8(4), С. 895 - 903

Опубликована: Сен. 11, 2023

Purpose: The pathogenesis of cerebral small vessel disease (cSVD) remains elusive despite evidence an association between white matter hyperintensities (WMH) and endothelial cerebrovascular dysfunction. Neurovascular coupling (NVC) may be a practical alternative measure function. We performed systematic review reported associations NVC cSVD. Methods: EMBASE PubMed were searched for studies reporting any STRIVE-defined marker cSVD during functional magnetic resonance imaging, transcranial Doppler, positron emission tomography, near-infrared spectroscopy or single-photon computed from inception to November 3rd, 2022. Where quantitative data was available using consistent tests analyses, results combined by inverse-variance weighted random effects meta-analysis. Findings: Of 29 (19 case-controls; 10 cohorts), 26 decreased with increasing severity cSVD, which 18 individually significant. In 28 WMH, 25 reduced NVC. Other markers associated in: eight nine microbleeds (six showing significant effect); three five lacunar stroke; no enlarged perivascular spaces. Specific SVD diseases particularly NVC, including six out seven in amyloid angiopathy all four CADASIL. limited meta-analyses, %BOLD occipital change visual stimulus consistently more severe WMH (seven studies, SMD −1.51, p < 0.01) −1.31, 0.01). Discussion Conclusion: multiple, neurovascular patients sporadic disease, CAA Cerebrovascular dysfunction, manifest as impaired common physiological dysfunction due injury that can easily measured large clinical practice.

Язык: Английский

Процитировано

14
Regular Consumption of Cocoa and Red Berries as a Strategy to Improve Cardiovascular Biomarkers via Modulation of Microbiota Metabolism in Healthy Aging Adults DOI Open Access

Joaquín García-Cordero,

Alba Martínez-Escudé,

Carlos Blanco-Valverde

и другие.

Nutrients, Год журнала: 2023, Номер 15(10), С. 2299 - 2299

Опубликована: Май 13, 2023

The aim of the present study was to analyze effects cocoa flavanols and red berry anthocyanins on cardiovascular biomarkers, such as homocysteine, angiotensin-converting enzyme (ACE), nitric oxide (NO), flow-mediated vasodilation (FMD), blood pressure lipid profile. Additionally, we aimed ascertain their possible interactions with microbiota related metabolites, secondary bile acids (SBA), short-chain fatty (SCFA) trimethylamine N-oxide (TMAO). A randomized, parallel-group study, single-blind for research team, performed 60 healthy volunteers between ages 45 85, who consumed 2.5 g/day powder (9.59 mg/day total flavanols), 5 a mixture (13.9 anthocyanins) or 7.5 combination both 12 weeks. group that had showed significant reduction in TMAO (p = 0.03) uric acid 0.01) levels serum, accompanied by an increase FMD values polyphenols. corrected creatinine after intervention. These latter negatively correlated concentration (R −0.57, p 0.02). observed carbohydrate fermentation groups 0.04) berries beginning end This lower TC/HDL ratio 0.01), systolic diastolic 0.01). In conclusion, our positive modulation metabolism regular intake led improvement function, especially cocoa.

Язык: Английский

Процитировано

13
Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension DOI Creative Commons
Zhichao Wang, Yijia Shao, Fang Wu

и другие.

Microbiological Research, Год журнала: 2024, Номер 287, С. 127824 - 127824

Опубликована: Июль 20, 2024

The gut microbial metabolite trimethylamine N-oxide (TMAO) is regarded as a novel risk factor for hypertension. Berberine (BBR) exerts cardiovascular protective effects by regulating the microbiota-metabolite production pathway. However, whether and how BBR alleviates TMAO-induced vascular dysfunction in hypertension remains unclear. In present study, we observed that plasma TMAO related bacterial abundance were significantly elevated negatively correlated with function 86 hypertensive patients compared 46 normotensive controls. activated endoplasmic reticulum stress (ERS) signaling pathway to promote endothelial cell apoptosis vitro. (100, 200 mg · kg

Язык: Английский

Процитировано

5