Journal of Clinical Hypertension, Год журнала: 2025, Номер 27(3)
Опубликована: Март 1, 2025
Язык: Английский
Journal of Hypertension, Год журнала: 2023, Номер 41(12), С. 1874 - 2071
Опубликована: Июнь 24, 2023
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering Sang Hyun Ihm (South Korea), Uday Jadhav (India), Manolis Kallistratos Kazuomi Kario (Japan), Vasilios Kotsis Adi Leiba (Israel), Patricio López-Jaramillo (Colombia), Hans-Peter Marti (Norway), Terry McCormack Paolo Mulatero Dike B. Ojji (Nigeria), Sungha Park Priit Pauklin (Estonia), Sabine Perl (Austria), Arman Postadzhian (Bulgaria), Aleksander Prejbisz Venkata Ram Ramiro Sanchez (Argentina), Markus Schlaich Alta Schutte Cristina Sekib Sokolovic (Bosnia and Herzegovina), Jonas Spaak (Sweden), Dimitrios Terentes-Printzios Bruno Trimarco Thomas Unger (The Netherlands), Bert-Jan van den Born Anna Vachulova Agostino Virdis Jiguang Wang (China), Ulrich Wenzel (Germany), Paul Whelton Jiri Widimsky (Czech Jacek Wolf Grégoire Wuerzner (Switzerland), Eugene Yang Yuqing Zhang (China).
Язык: Английский
Процитировано
1507
Life, Год журнала: 2024, Номер 14(7), С. 856 - 856
Опубликована: Июль 8, 2024
Obesity is an important condition affecting the quality of life numerous patients and increasing their associated risk for multiple diseases, including tumors immune-mediated disorders. Inflammation appears to play a major role in development obesity represents central point activity cellular humoral components adipose tissue. Macrophages key as main component tissue regulating chronic inflammation modulating secretion differentiation various pro- anti-inflammatory cytokines. also involves series signaling pathways that might represent focus new therapies interventions. Weight loss essential decreasing cardiometabolic risks degree inflammation; however, latter can persist long after excess weight lost, involve changes macrophage phenotypes ensure metabolic adjustment. A clear understanding pathophysiological processes interplay between lead better comorbidities may future targets treatment obesity.
Язык: Английский
Процитировано
23
Journal of Cardiovascular Development and Disease, Год журнала: 2023, Номер 10(3), С. 127 - 127
Опубликована: Март 16, 2023
Arterial stiffness is a recognized predictor of cardiovascular morbidity and death. It an early indicator arteriosclerosis influenced by numerous risk factors biological processes. The lipid metabolism crucial standard blood lipids, non-conventional markers ratios are associated with arterial stiffness. objective this review was to determine which marker has greater correlation vascular aging Triglycerides (TG) the lipids that have strongest associations stiffness, often linked stages diseases, particularly in patients low LDL-C levels. Studies show perform better overall than any individual variables used alone. relation between TG/HDL-C evidence. profile atherogenic dyslipidemia found several chronic cardio-metabolic disorders, considered one main causes lipid-dependent residual risk, regardless concentration. Recently, use alternative parameters also been increasing. Both non-HDL ApoB very well correlated Remnant cholesterol promising parameter. findings suggest focus should be on especially individuals disorders risk.
Язык: Английский
Процитировано
31
AJP Heart and Circulatory Physiology, Год журнала: 2023, Номер 325(1), С. H1 - H29
Опубликована: Март 31, 2023
Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age identify individuals at elevated CV risk. We review possibilities, limitations, complementarity, differences reduced-order, biophysical models arterial PW propagation, well theoretical empirical methods for analyzing extracting clinically relevant assessment. provide detailed mathematical derivations these methods, showing how they are related each other. Finally, we outline directions future research realize potential modeling analysis accurate assessment in both clinic daily life.
Язык: Английский
Процитировано
27
Hypertension, Год журнала: 2023, Номер 80(10), С. 1980 - 1992
Опубликована: Июль 20, 2023
This review critiques the literature supporting clinical assessment and management of cardiovascular disease risk stratification with brachial-ankle pulse wave velocity (baPWV). First, we outline what baPWV actually measures-arterial stiffness both large central elastic arteries medium-sized muscular peripheral lower limb. Second, argue that is not a surrogate for carotid-femoral velocity. While measures are dependent on properties aorta, also strongly extremities. Increased lower-extremity arterial amplifies hastens reflections at level widens pressure, increases afterload, reduces coronary perfusion. Third, used an established evaluation framework to identify value as independent vascular biomarker. There sufficient evidence support (1) proof concept; (2) prospective validation; (3) incremental value; (4) utility. However, there limited or no (5) outcomes; (6) cost-effectiveness; (8) methodological consensus; (9) reference values. Fourth, address future research requirements. The majority criteria, concept, validation, value, utility values, can be supported using existing cohort datasets, whereas outcomes cost-effectiveness criteria require investigation. consensus will expert statement. Finally, finish this by providing example practice model.
Язык: Английский
Процитировано
25
Journal of the American Heart Association, Год журнала: 2023, Номер 12(10)
Опубликована: Май 15, 2023
Magnetic resonance imaging and computed tomography allow the characterization of arterial state function with high confidence thus play a key role in understanding aging its translation into clinic. Decades research development innovative sequences image analysis techniques have led to identification large number potential biomarkers, some bringing improvement basic science, others clinical practice. Nonetheless, complexity these biomarkers required for their computation hamper widespread use. In this narrative review, current related aorta, founding principles, sequence, postprocessing required, predictive values cardiovascular events are summarized. For each biomarker summary reference reproducibility studies limitations is provided. The present developed COST Action VascAgeNet, aims guide clinicians technical researchers critical possibilities offered by advanced modalities studying possible clinically relevant relationships aging.
Язык: Английский
Процитировано
17
Cardiovascular Research, Год журнала: 2024, Номер unknown
Опубликована: Апрель 21, 2024
The vascular aging process accelerated by type 2 diabetes mellitus (T2DM) is responsible for the elevated risk of associated cardiovascular diseases (CVDs). Metabolic disorder-induced immune senescence has been implicated in multi-organ/tissue damage. Herein, we sought to determine role immunosenescence diabetic and investigate underlying mechanisms.
Язык: Английский
Процитировано
7
Frontiers in Genetics, Год журнала: 2024, Номер 15
Опубликована: Фев. 26, 2024
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, cellular state characterized by cell-cycle arrest, senescence-associated secretory phenotype macromolecular damage, metabolic dysregulation. senescence has been demonstrated play key role in different vascular diseases, such as atherosclerosis, peripheral arterial disease, hypertension, stroke, diabetes, chronic venous ulcers. Even though was first described 1961, significant gaps persist comprehending the epigenetic driving its subsequent inflammatory response. Through comprehensive analysis, we aim elucidate these knowledge exploring network alterations that contribute senescence. In addition, describe consequent cascades triggered modifications. Finally, explore translational applications involving biomarkers emerging field senotherapy targeting this biological process.
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11188 - 11188
Опубликована: Окт. 17, 2024
Vascular aging encompasses structural and functional changes in the vasculature, significantly contributing to cardiovascular diseases, which are leading cause of death globally. The incidence prevalence these diseases increase with age, most morbidity mortality attributed myocardial infarction stroke. Diagnosing intervening vascular while understanding mechanisms behind age-induced phenotypic pathophysiological alterations offers potential for delaying preventing an population. This review delves into various aspects by examining age-related arterial health at cellular level, including endothelial dysfunction, senescence, smooth muscle cell transdifferentiation, as well stiffness wall thickness diameter. We also explore aging-related perivascular adipose tissue deposition, collateralization, calcification, providing insights physiological pathological implications. Overall, induces that augment system’s susceptibility disease, even absence traditional risk factors, such hypertension, diabetes, obesity, smoking. modifications phenotype molecular homeostasis vulnerability vasculature alterations, thereby accelerating risk. Increasing our is crucial success or diseases. Non-invasive techniques, measuring carotid intima-media thickness, pulse wave velocity, flow-mediated dilation, detecting calcifications, can be used early detection aging. Targeting specific mechanisms, senescence enhancing angiogenesis, holds promise innovative therapeutic approaches.
Язык: Английский
Процитировано
6
Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102122 - 102122
Опубликована: Ноя. 11, 2023
Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness endothelial dysfunction are key components, is associated with increased risk cardiovascular other age-related diseases. As the global population continues to age, understanding underlying mechanisms developing effective therapeutic interventions mitigate vascular ageing becomes crucial for improving health outcomes. Therefore, this review provides an overview current knowledge on pharmacological modulation highlighting strategies promising targets. Several molecular pathways have been identified as central players including oxidative stress inflammation, renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, gasotransmitter-related signalling. Pharmacological dietary targeting these shown potential ameliorating changes. Nevertheless, development application drugs complicated various inherent challenges limitations, such certain preclinical methodological considerations, interactions exercise training sex/gender-related differences, should be taken into account. Overall, hallmarks holds great promise population. Nonetheless, further research needed fully elucidate optimize efficacy safety clinical translation.
Язык: Английский
Процитировано
13