Nanoparticles as a Novel Platform for Cardiovascular Disease Diagnosis and Therapy
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8831 - 8846
Опубликована: Авг. 1, 2024
Cardiovascular
disease
(CVD)
is
a
major
global
health
issue
with
high
mortality
and
morbidity
rates.
With
the
advances
in
nanotechnology,
nanoparticles
are
receiving
increasing
attention
diagnosing
treating
CVD.
Previous
studies
have
explored
use
of
noninvasive
diagnostic
technologies,
such
as
magnetic
resonance
imaging
computed
tomography.
Nanoparticles
been
extensively
studied
drug
carriers
prognostic
factors,
demonstrating
synergistic
efficacy.
This
review
summarized
current
applications
CVD
discussed
their
opportunities
challenges
for
further
exploration.
Язык: Английский
Biomaterials for cardiovascular diseases
Biomedical Technology,
Год журнала:
2024,
Номер
7, С. 1 - 14
Опубликована: Июнь 5, 2024
Cardiovascular
disease
(CVD)
remains
a
leading
cause
of
mortality
worldwide,
claiming
countless
lives
and
posing
formidable
health
challenge.
Extensive
efforts
have
been
dedicated
to
combating
this
disease,
including
the
development
innovative
biomaterials
for
blood
vessel
stents,
drug
delivery
imaging
diagnosis.
These
advancements
substantially
addressed
issues
such
as
patient
rejection
contamination.
In
review,
we
begin
by
outlining
prevalence
various
forms
CVD.
Subsequently,
delve
into
advanced
biomaterials—including
synthetic
biomaterials,
natural
hybrid
biomaterials—and
medical
instruments
used
in
treatment
or
alleviation
CVD,
discussing
their
advantages
limitations.
Finally,
offer
insights
future
prospects
strategies
refining
these
technologies
moving
forward.
Язык: Английский
Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases
Clinical Reviews in Allergy & Immunology,
Год журнала:
2025,
Номер
68(1)
Опубликована: Фев. 10, 2025
Under
the
concept
of
"one
airway,
one
disease",
upper
and
lower
airway
inflammatory
diseases
share
similar
pathogenic
mechanisms
are
collectively
referred
to
as
diseases.
With
industrial
development
environmental
changes,
incidence
these
has
gradually
increased.
Traditional
treatments,
including
glucocorticoids,
antihistamines,
bronchodilators,
have
alleviated
much
discomfort
experienced
by
patients.
However,
conventional
drug
delivery
routes
inherent
flaws,
such
significant
side
effects,
irritation
respiratory
mucosa,
issues
related
deactivation.
In
recent
years,
nanomaterials
emerged
excellent
carriers
for
being
increasingly
utilized
in
treatment
These
materials
not
only
optimize
traditional
medications
but
also
facilitate
administration
various
new
drugs
that
target
novel
pathways,
thereby
enhancing
outcomes
This
study
reviews
latest
research
on
nano-drug
systems
used
diseases,
covering
drugs,
immunotherapy
antimicrobial
plant-derived
RNA
drugs.
The
challenges
involved
developing
nano-delivery
discussed,
along
with
a
future
outlook.
review
offers
insights
researchers
can
utilize
advance
further
into
clinical
application
treating
Язык: Английский
Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 4, 2025
Nowadays,
emerging
evidence
have
suggested
that
the
ferroptosis
of
macrophages
could
contribute
to
progression
atherosclerosis
(AS).
Meanwhile,
Spermine
(Sp)
serve
as
an
endogenous
small
molecule
exhibiting
a
wide
range
cardiovascular
protective
effects.
Zeolitic
imidazolate
framework-90
(ZIF90)
nanoparticles
were
synthesized
and
utilized
create
novel
delivery
nanosystem
encapsulated
with
Sp
(CD16/32-ZIF90@Sp).
The
efficacy
CD16/32-ZIF90@Sp
in
protecting
against
AS
was
evaluated
ApoE-/-
mice
macrophages,
focus
on
assessing
potential
adverse
effects
vivo.
exhibited
reliable
stable
within
acidic
environments
ATP
sensitivity.
effectively
reduced
cytotoxicity
Sp.
As
is
evidenced
by
vitro
vivo
experiments,
showed
precise
targeting
atherosclerotic
plaques
ox-LDL-activated
macrophages.
Furthermore,
treatment
attenuated
macrophage
plaque
without
causing
significant
side
Mechanistically,
we
found
inhibited
via
improving
mitochondrial
function
upregulating
expression
level
GPX4/xCT.
Our
study
demonstrated
CD16/32-modified
ZIF90
target
plaques,
leading
inhibition
mice.
These
attributed
enhancement
ferroptosis,
limited
Язык: Английский
How Advanced Is Nanomedicine for Atherosclerosis?
Xiang Gu,
Lixin Du,
Ran Lin
и другие.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 3445 - 3470
Опубликована: Март 1, 2025
Advances
in
nanotechnology
have
opened
new
avenues
for
precision
therapy,
personalized
medicine,
and
multifunctional
theranostics
atherosclerosis
(AS).
This
review
provides
a
comprehensive
overview
of
the
role
nanoparticles
(NPs)
medicine
AS,
discussing
their
applications,
challenges,
future
prospects.
The
first
analyzes
current
treatment
landscape
AS
outlines
potential
biological
targets
therapy.
Various
nanocarriers,
including
organic,
inorganic,
hybrid
systems,
are
evaluated
therapeutic
potential,
with
focus
on
targeted
drug
delivery,
anti-inflammatory
vascular
repair,
plaque
stabilization,
lipid
clearance.
Additionally,
explores
NP
preparation
methods,
emphasizing
strategies
to
enhance
loading,
stability,
controlled
release.
Finally,
translational
challenges
NP-based
therapies,
biocompatibility,
large-scale
production,
regulatory
hurdles,
clinical
implementation,
critically
analyzed.
Future
directions
highlight
importance
interdisciplinary
collaboration
technological
innovation
advancing
nanoparticle-based
AS.
Язык: Английский
Nanomedicine-based strategies for the treatment of vein graft disease
Nature Reviews Cardiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Язык: Английский
Hydrogel-to-Nanoparticle Transition with Immune Cell Activation Controlled by Dual Supramolecular Interactions
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Biomolecules
may
undergo
dynamic
transitions
between
different
aggregation
states
in
order
to
adapt
the
microenvironment.
As
a
result,
appropriate
biofunctions
can
be
performed
only
under
certain
states.
This
feature
inspires
exploration
for
constructing
and
regulating
environmentally
adaptive
materials
through
supramolecular
ways.
Herein,
we
propose
strategy
employ
special
pair
of
interactions,
very
strong
binding
fluorescent
proteins
their
nanobodies
together
with
rather
weak
α-cyclodextrin
poly(ethylene
glycol),
construct
protein-containing
polymeric
hydrogel
hydrogel-to-particle
transition.
The
property
originally
homogeneous
was
demonstrated
by
dilution
physiological
conditions,
when
complete
dissociation
nanoparticles
observed.
fascinating
achieved
via
coupling
protein-nanobody
polypseudorotaxane,
which
supported
transition
stability
resultant
particles.
Such
found
efficiently
promote
migration
immune
cells
activate
them
secrete
proinflammatory
cytokines,
indicating
bright
future
immunotherapy.
Язык: Английский