Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999–2002 DOI Creative Commons
Xiaolang Chen, Jin Zhong, Yingnan Lv

и другие.

Clinical Epigenetics, Год журнала: 2025, Номер 17(1)

Опубликована: Май 31, 2025

Currently, with the global aging of population, inflammation, recognized as a hallmark in age-related diseases, has been studied and linked to cardiovascular diseases (CVD). However, limited evidence on whether inflammation modifies epigenetic affects CVD risk. This study included 404 patients 1941 non-CVD individuals from 1999-2002 National Health Nutrition Examination Survey cross-sectional data. Low-grade systemic was assessed using C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), response index (SIRI). Epigenetic age accelerations (EAAs) were calculated residuals between chronological ages: Horvath acceleration (AgeAccel), AgeAccelHannum, AgeAccelPheno. Weighted linear logistic regression analyzed associations exposures outcomes, mediating effects Sobel test. After adjusting confoundings, log-transformed NLR SIRI positively associated risk, odds (OR) ranges 1.260 1.354 (all P < 0.05). Furthermore, ln-transformed CRP AgeAccelHannum AgeAccelPheno, coefficient (β) 0.505 1.304 0.05); all three EAAs, β 0.392 2.212 0.005). Additionally, 1-unit increase AgeAccelPheno 2.8% (OR: 1.028, 95% CI 1.007-1.049, = 0.011) 3.5% 1.035, 1.014-1.056, 0.002) respectively. mediation analysis showed that mediates 10.44% (P 0.046) association risk; 24.03% 0.009) 18.16% 0.015) NLR-CVD SIRI-CVD risk associations, Our results demonstrate EAAs mediate highlighting potential multi-target approach modifications for personalized management reduce

Язык: Английский

Aging at the Crossroads of Organ Interactions: Implications for the Heart DOI
Ilke Sen,

Natasha A. Trzaskalski,

Yung‐Ting Hsiao

и другие.

Circulation Research, Год журнала: 2025, Номер 136(11), С. 1286 - 1305

Опубликована: Май 22, 2025

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate aging through cellular senescence, tissue wasting, accelerated atherosclerosis, increased vascular stiffness, reduction in blood flow, leading to organ remodeling premature failure. This interorgan/tissue crosstalk aging-related dysfunction inflammation, senescence-associated secretome, metabolic mitochondrial changes resulting oxidative stress, microvascular dysfunction, reprogramming, fibrosis. may also underscore the rising incidence co-occurrence of multiorgan population. Examples include between lungs, kidneys, liver, muscles, brain, among others. However, this phenomenon present new translational opportunities for identifying diagnostic biomarkers define early risks gain mechanistic insights, help design precision-directed therapeutic interventions. Indeed, opens development targeting multiple organs simultaneously disrupt crosstalk-driven process mutual disease acceleration. New targets could provide synergistic benefits across systems same at-risk patient. Ultimately, these approaches together slow itself throughout body. In future, with patient-centered multisystem coordinated approaches, we initiate a paradigm risk prediction tailored intervention. With emerging tools including artificial intelligence–assisted profiling novel preventive strategies (eg, RNA-based therapeutics), be able mitigate much earlier and, perhaps, even itself.

Язык: Английский

Процитировано

1
Associations of Serum Uric Acid-to-High Density Lipoprotein Cholesterol Ratio with Age-related Diseases and Mortality Among Older Population in the United States DOI
Ziqi Chen, Iokfai Cheang, Qiang Qu

и другие.

Archives of Gerontology and Geriatrics, Год журнала: 2024, Номер 130, С. 105707 - 105707

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

6
Ozone exposure and increased risk of age-related macular degeneration: Evidence from nationwide cohort and toxicological studies DOI Creative Commons
Guanran Zhang, Yanlin Qu, Xiaoling Wan

и другие.

The Innovation, Год журнала: 2025, Номер unknown, С. 100808 - 100808

Опубликована: Фев. 1, 2025

Evidence regarding the impact of ozone on age-related macular degeneration (AMD) remains limited. We conducted a nationwide cohort analysis 27,923 participants in China, along with random control animal toxicological study, to elucidate temporal relationship between exposure and AMD as well underlying biological explanation. In population 5,149 were diagnosed incident during 348,701 person-month follow-up. The divided into low-, medium-, high-exposure groups. Fully adjusted Cox regression models showed that risk increased by 28% for medium- 101% groups relative low-exposure group (p trend < 0.001). exposure-response curves exhibited J-shaped trend. Sensitivity analyses confirmed these results, revealing stronger associations among older than 65 years old those living rural or northern China. mice randomized inhale filtered air, exposed had photoreceptor damage vision impairment, which are hallmarks AMD. further clarified contributes activating systemic inflammation detailing how external air-pollutant-induced factors reach retina, is innermost layer eye, cause retinal disease. Our comprehensive studies provide key evidence risk, suggesting visual health benefits collaboratively enforcing necessary pollution policies, especially regions high concentrations, within context globally aging population.

Язык: Английский

Процитировано

0
Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging DOI Creative Commons
Feng Zhang,

Rong Li,

Yasong Liu

и другие.

iMeta, Год журнала: 2025, Номер 4(3)

Опубликована: Апрель 12, 2025

Aging-related decline and adaptation are complex, multifaceted processes that affect various tissues increase risk of chronic diseases. To characterize key changes in cross-tissue aging, we performed comprehensive proteomic metabolomic analyses across 21 solid plasma samples, alongside shotgun metagenomic profiling fecal microbial communities young aged mice. Our findings revealed widespread aging-rewired inflammation, characterized by complement system activation universal immunoglobulins accumulation multiple tissues. This inflammatory remodeling significantly enhanced vulnerability to aging-related tissue injury. Moreover, identified organ-specific organ-enriched proteins with high functional specificity. Among these, were closely linked disorders arising from lipid metabolism dysfunction. Analysis multi-tissue profiles aging disrupted inter-tissue metabolic coupling, activities polyunsaturated fatty acids metabolism, gut microbiota homeostasis. Aged mice exhibited a marked decrease Escherichia an Helicobacter, strongly correlating alterations omega-3 omega-6 acid abundances. Through multi-omics integration, molecular hubs driving organismal responses aging. Collectively, our study uncovers extensive aging-associated tissues, emphasizing the interplay between systemic inflammation dysbiosis-driven remodeling. These provide deeper insights into development healthy perspective.

Язык: Английский

Процитировано

0
Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999–2002 DOI Creative Commons
Xiaolang Chen, Jin Zhong, Yingnan Lv

и другие.

Clinical Epigenetics, Год журнала: 2025, Номер 17(1)

Опубликована: Май 31, 2025

Currently, with the global aging of population, inflammation, recognized as a hallmark in age-related diseases, has been studied and linked to cardiovascular diseases (CVD). However, limited evidence on whether inflammation modifies epigenetic affects CVD risk. This study included 404 patients 1941 non-CVD individuals from 1999-2002 National Health Nutrition Examination Survey cross-sectional data. Low-grade systemic was assessed using C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), response index (SIRI). Epigenetic age accelerations (EAAs) were calculated residuals between chronological ages: Horvath acceleration (AgeAccel), AgeAccelHannum, AgeAccelPheno. Weighted linear logistic regression analyzed associations exposures outcomes, mediating effects Sobel test. After adjusting confoundings, log-transformed NLR SIRI positively associated risk, odds (OR) ranges 1.260 1.354 (all P < 0.05). Furthermore, ln-transformed CRP AgeAccelHannum AgeAccelPheno, coefficient (β) 0.505 1.304 0.05); all three EAAs, β 0.392 2.212 0.005). Additionally, 1-unit increase AgeAccelPheno 2.8% (OR: 1.028, 95% CI 1.007-1.049, = 0.011) 3.5% 1.035, 1.014-1.056, 0.002) respectively. mediation analysis showed that mediates 10.44% (P 0.046) association risk; 24.03% 0.009) 18.16% 0.015) NLR-CVD SIRI-CVD risk associations, Our results demonstrate EAAs mediate highlighting potential multi-target approach modifications for personalized management reduce

Язык: Английский

Процитировано

0