The American Journal of Cardiology, Год журнала: 2024, Номер 224, С. 36 - 45
Опубликована: Июнь 12, 2024
Язык: Английский
Nature Reviews Cardiology, Год журнала: 2024, Номер 21(9), С. 603 - 616
Опубликована: Май 2, 2024
Язык: Английский
Процитировано
29
European Heart Journal, Год журнала: 2024, Номер 45(38), С. 4099 - 4110
Опубликована: Сен. 6, 2024
Abstract Emerging evidence indicates that chemical exposures in the environment are overlooked drivers of cardiovascular diseases (CVD). Recent suggests micro- and nanoplastic (MNP) particles derived largely from or mechanical degradation plastics might represent a novel CVD risk factor. Experimental data preclinical models suggest MNPs can foster oxidative stress, platelet aggregation, cell senescence, inflammatory responses endothelial immune cells while promoting range metabolic alterations lead to disease premature death. In humans, various plastics, including polyethylene polyvinylchloride, have been detected atherosclerotic plaques other tissues, pericardia, epicardial adipose pericardial myocardia, left atrial appendages. measurable levels within thrombi seem accumulate preferentially areas vascular lesions. Their presence carotid is associated with subsequent increased incidence events. To further investigate possible causal role CVD, future studies should focus on large, prospective cohorts assessing exposure individuals plastic-related pollution, routes absorption, existence putative safety limit, correspondence between accumulation timing development, pathophysiological mechanisms instigated by pertinent concentrations MNPs. Data such would allow design preventive, even therapeutic, strategies. Meanwhile, existing reducing plastic production use will produce benefits for human health. This goal could be achieved through UN Global Plastics Treaty currently negotiation.
Язык: Английский
Процитировано
18
American Journal of Lifestyle Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Cardiovascular disease (CVD) remains a significant global health concern for women, influenced by complex interplay of social, economic, and environmental factors. This article examines cardiovascular risk through the lens exposome, which encompasses all exposures from conception onward, including pollution, diet, chronic stress. Social determinants such as socioeconomic status (SES), education, stress management play crucial roles in shaping women’s health. Lower SES education are associated with greater exposure to adverse living conditions, poor nutrition, limited access healthcare, increasing CVD. Environmental particularly air pollution climate-related changes, further exacerbates promoting oxidative inflammation. Additionally, gender-specific factors, pregnancy menopause, interact heightening vulnerability women risks over their lifetime. Addressing these factors requires comprehensive approach, incorporating public strategies that focus on reducing improving food security, mitigating social inequalities. By addressing cumulative interacting contribute disease, especially more effective prevention can be developed improve long-term outcomes.
Язык: Английский
Процитировано
1
Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12
Опубликована: Фев. 10, 2025
Background Systemic inflammation, immune and nutrition status are closely linked to the occurrence development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV) is a new method for evaluating systemic inflammation status. Our objective explore connection between PIV CHD especially in elderly people, as well diagnostic combined with controlling nutritional (COUNT) score CHD. Methods Participants eligible study were sourced from NHANES data 1999 2018. Logistic regression models employed evaluate link Additionally, restricted cubic spline was utilized correlations. Subgroup analysis adopted order ensure credibility results. The receiver operator characteristic (ROC) curve used predictive COUNT Results 41,713 individuals qualified analysis. had higher levels PIV. In logistic model, positively related [Q4 vs. Q1, OR = 1.23 (1.03–1.48, P < 0.001)]. Restricted indicated positive non-linear relationship ( overall <0.001, 0.009). However, shows that this correlation only significant population aged 60 above. more 0.001). ROC has better than other common inflammatory indicators. Furthermore, combination superior or score. Conclusions A CHD, elderly.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1708 - 1708
Опубликована: Фев. 17, 2025
The endothelium is pivotal in multiple physiological processes, such as maintaining vascular homeostasis, metabolism, platelet function, and oxidative stress. Emerging evidence the past decade highlighted immunomodulatory function of endothelium, serving a link between innate, adaptive immunity inflammation. This review examines regulation immune-inflammatory axis by discusses immune functions, explores pathophysiological processes leading to endothelial dysfunction various metabolic disturbances, including hyperglycemia, obesity, hypertension, dyslipidaemia. final section focuses on novel, repurposed, emerging therapeutic targets that address dysfunction.
Язык: Английский
Процитировано
1
Nutrition Research, Год журнала: 2024, Номер 126, С. 46 - 57
Опубликована: Март 22, 2024
Among the often-neglected features of healthy diets, such as Mediterranean one is preparation and sharing food, which (or was) done in a social environment governed by rules rather than time constraints. The act eating daily human practice that not limited to meeting nutritional energy needs but also involves constructed dimension meals part process civilisation food cultures around world. In this narrative review we outline importance conviviality driving health effects healthful with special reference diet. Based on available evidence, suggest public initiatives (such nudging promote conviviality) improve people's living styles, reduce loneliness, could health. Interventions aimed at directly increasing/improving relationships, networking, can - indirectly both psychological well-being general
Язык: Английский
Процитировано
8
Heliyon, Год журнала: 2024, Номер 10(18), С. e38047 - e38047
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
8
European Heart Journal, Год журнала: 2024, Номер unknown
Опубликована: Дек. 24, 2024
Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity mortality. Its pathogenesis intricately linked to deleterious impact of cardiovascular risk factors, emphasizing pivotal imperative for early detection mitigation strategies targeting these factors prevention primary AF. While traditional are well recognized, an increasing number novel have been identified in recent decades. This review explores emerging non-traditional AF, including unhealthy lifestyle current society (sleep, night shift work, diet), biomarkers (gut microbiota, hyperuricaemia, homocysteine), adverse conditions or diseases (depression, epilepsy, clonal haematopoiesis indeterminate potential, infections, asthma), environmental (acoustic pollution other factors). Unlike individuals limited control over many posing challenges conventional strategies. The purpose this outline evidence on associations new-onset AF potential mechanisms related factors. Furthermore, aims explore interventions at both individual societal levels mitigate growing burden suggesting guideline updates prevention.
Язык: Английский
Процитировано
8
Trends in Cardiovascular Medicine, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Angina pectoris, a primary manifestation of ischemic heart disease, imposes significant clinical and economic burden globally. This review highlights recent advancements in the management angina, emphasizing patient-centred approach that integrates pharmacological, interventional, lifestyle strategies to reduce cardiovascular risk improve patient outcomes. For obstructive coronary artery optimal medical therapy represents cornerstone treatment. Individualized regimens should be tailored factors such as blood pressure, rate, left ventricular function, comorbidities like failure diabetes, concomitant medications, preferences, drug availability. Myocardial revascularization is reserved for select cases alleviate symptoms or prognosis. angina ischemia with non-obstructive arteries (ANOCA/INOCA), precise endotype classification, differentiating microvascular vasospastic mixed type non-coronary chest pain, enables personalized treatment strategies. Lifestyle interventions, including smoking cessation, weight management, adherence Mediterranean diet, exercise therapy, are essential components care, promoting improved outcomes quality life. Structured programs, particularly within cardiac rehabilitation settings, have demonstrated efficacy enhancing functional capacity reducing adverse events. Emerging therapies, pharmacological agents novel interventional approaches sinus reducer, hold promise addressing unmet needs refractory challenging ANOCA/INOCA cases. Future directions prioritize integration precision medicine, digital health technologies, multidisciplinary care optimize advance management.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4232 - 4232
Опубликована: Апрель 11, 2024
Atherosclerosis, a complex metabolic-immune disease characterized by chronic inflammation driven the buildup of lipid-rich plaques within arterial walls, has emerged as pivotal factor in intricate interplay between cancer and cardiovascular disease. This bidirectional relationship, marked shared risk factors pathophysiological mechanisms, underscores need for comprehensive understanding how these two formidable health challenges intersect influence each other. Cancer its treatments can contribute to progression atherosclerosis, while with inflammatory microenvironment, exert profound effects on development outcomes. Both involve interactions general personal exposomes. In this review, we aim summarize state art translational data try show oncologic studies cardiotoxicity broaden our knowledge crucial pathways biology positive impact precision cardiology cardio-oncology.
Язык: Английский
Процитировано
6