Meditsinskiy sovet = Medical Council,
Год журнала:
2024,
Номер
11, С. 93 - 99
Опубликована: Авг. 6, 2024
Breast
milk
is
the
“gold
standard”
for
feeding
infants
first
years
of
life
and
affects
children
health
both
at
an
early
age
in
subsequent
periods
their
life.
However,
there
are
times
when
women
unable
to
breastfeed
following
reasons:
a
woman
cannot
make
or
has
problems,
lose
interest
breastfeeding,
should
be
back
work,
etc.
This
brings
up
legitimate
question:
how
choose
among
large
number
infant
formulas
healthy
one
that
will
fit
safe
child
use,
taking
into
account
gestational
age,
as
well
individual
“risk
facts”
such
high
low
body
mass
height
parameters,
features
childbirth
(“vaginal”,
operative
delivery),
Most
often,
choice
falls
on
cow-milk-based
formula.
After
all,
not
forget
about
alternative
options
goat-milk-based
formulas.
Historical
evidence
shows
patients
with
rickets
were
fed
goat
it
was
believed
affect
brain
functions.
Interest
beneficial
effects
goat’s
been
steadily
increasing
this
day,
given
biological
active
substances
present
also
women’s
larger
quantities.
The
β
-casein
fraction
its
main
component,
which
makes
similar
breast
structure
possible.
In
addition
proteins,
fats
components
contribute
excellent
digestibility
milk.
Their
distinctive
feature
smaller
size
compared
from
other
animals.
article
explores
all
benefits
effect
aspects
health.
Urbanization
has
significantly
transformed
dietary
habits
worldwide,
contributing
to
a
globally
increased
burden
of
non-communicable
diseases
and
altered
gut
microbiota
landscape.
However,
it
is
often
overlooked
that
the
adverse
effects
these
changes
can
be
transmitted
from
mother
offspring
during
early
developmental
stages,
subsequently
influencing
predisposition
various
later
in
life.
This
review
aims
delineate
detrimental
maternal
urban-lifestyle
diet
(urbanized
diet)
on
early-life
health
assembly,
provide
mechanistic
insights
how
urbanized
mediates
mother-to-offspring
transfer
bioactive
substances
both
intrauterine
extrauterine
thus
affects
fetal
neonatal
development.
Moreover,
we
also
further
propose
framework
for
developing
microbiome-targeted
precision
nutrition
strategies
specifically
pregnant
lactating
women.
The
establishment
such
knowledge
help
develop
proactive
preventive
measures
beginning
life,
ultimately
reducing
long-term
risk
disease
improving
public
outcomes.
Nutrients,
Год журнала:
2024,
Номер
16(9), С. 1287 - 1287
Опубликована: Апрель 25, 2024
Human
milk
oligosaccharides
(HMOs)
are
complexes
that
play
a
crucial
role
in
shaping
the
early-life
gut
microbiota.
This
study
intends
to
explore
whether
HMO
patterns
associated
with
microbiota
of
infants.
We
included
96
Chinese
breastfeeding
mother–infant
dyads.
Breast
and
infant
faecal
samples
were
collected
tested.
With
2′-fucosyllactose,
difucosyllactose,
lacto-N-fucopentaose-I
as
biomarkers,
we
divided
mothers
into
secretor
non-secretor
groups.
extracted
using
principal
component
analysis.
The
majority
(70.7%)
categorised
five
different
identified.
After
adjustment,
infants
exhibited
lower
relative
abundance
Bifidobacterium
bifidum
(β
=
−0.245,
95%CI:
−0.465~−0.025).
An
pattern
characterised
by
high
levels
3-fucosyllactose,
lacto-N-fucopentaose-III,
lacto-N-neodifucohexaose-II
was
positively
breve
(p
0.014),
while
lacto-N-neotetraose,
6′-sialyllactose,
sialyllacto-N-tetraose-b
negatively
0.027).
monofucosyl-lacto-N-hexaose-III
monofucosyl-lacto-N-neohexaose
dentium
0.025)
<
0.001),
respectively.
suggests
from
mature
breast
certain
breastfed
Frontiers in Pediatrics,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 5, 2024
Human
milk
oligosaccharides
(HMOs)
are
a
diverse
group
of
structures
and
an
abundant
bioactive
component
breastmilk
that
contribute
to
infant
health
development.
Preclinical
studies
indicate
roles
for
HMOs
in
shaping
the
gut
microbiota,
inhibiting
pathogens,
modulating
immune
system,
influencing
cognitive
In
past
decade,
several
industrially
produced
have
become
available
fortify
formula.
Clinical
intervention
trials
with
manufactured
begun
corroborate
some
physiological
effects
reported
preclinical
studies,
especially
modulation
microbiota
direction
breastfed
infants.
As
more
commercially
as
shared
mechanisms
action,
there
is
need
better
understand
unique
differential
individual
benefits
combining
multiple
HMOs.
This
review
focuses
on
different
HMO
structural
classes
presents
scientific
rationale
why
structurally
expected
exert
greater
biological
effects.
Microorganisms,
Год журнала:
2024,
Номер
12(8), С. 1625 - 1625
Опубликована: Авг. 9, 2024
Recent
evidence
has
highlighted
the
role
of
gut–brain
axis
in
progression
autism
spectrum
disorder
(ASD),
with
significant
changes
gut
microbiome
individuals
this
condition.
This
report
investigates
effects
probiotics
and
human
milk
oligosaccharide
(HMO)
supplements
on
microbiome,
inflammatory
cytokine
profile,
clinical
outcomes
an
ASD
adolescent
chronic
gastrointestinal
dysfunction
cognitive
impairment.
Following
treatment,
we
observed
a
decrease
proinflammatory
cytokines’
concentration
alongside
Sutterella
relative
abundance,
bacterium
reported
to
be
linked
diseases.
Also,
notable
increase
mood
stability.
The
study
aims
evaluate
use
microbiome-based
therapy
selected
patients,
highlighting
its
potential
improve
related
symptoms.
Carbohydrate Research,
Год журнала:
2024,
Номер
537, С. 109069 - 109069
Опубликована: Фев. 22, 2024
Milk
oligosaccharides,
complex
carbohydrates
unique
to
mammalian
milk,
play
crucial
roles
in
infant
nutrition
and
immune
development.
This
review
explores
their
biochemical
diversity,
tracing
the
evolutionary
paths
that
have
led
variation
across
different
species.
We
highlight
intersection
of
nutrition,
biology,
chemistry
understanding
these
compounds.
Additionally,
we
discuss
latest
computational
methods
analytical
techniques
revolutionized
study
milk
offering
insights
into
structural
complexity
functional
roles.
brief
but
essential
not
only
aims
provide
a
deeper
oligosaccharides
also
road
toward
potential
applications.
Abstract
Breastfeeding
represents
a
strong
selective
factor
for
shaping
the
infant
gut
microbiota.
Besides
providing
nutritional
requirements
infant,
human
milk
is
key
source
of
oligosaccharides,
oligosaccharides
(HMOs),
and
diverse
microbes
in
early
life.
This
study
aimed
to
evaluate
influence
microbiota
on
composition
faecal
at
one,
three,
nine
months
postpartum.
We
profiled
microbiota,
HMOs,
from
23
mother–infant
pairs
these
time
points.
The
predominant
genera
samples
were
Streptococcus
,
Staphylococcus
an
unclassified
Enterobacteriaceae
genus-level
taxon
(
uncl.),
whereas
was
predominated
by
Bifidobacterium,
Bacteroides
uncl.
Mother–infant
dyads
frequently
shared
bacterial
amplicon
sequence
variants
(ASVs)
belonging
Streptococcus,
Veillonella,
Haemophilus.
individual
HMO
concentrations
showed
either
no
change
or
decreased
over
lactation
period,
except
3-fucosyllactose
(3-FL),
which
increased.
Neither
maternal
secretor
status
nor
significantly
associated
with
different
ages
ASVs
faeces.
suggests
age-dependent
role
while
variations
show
limited
influence.
Human
milk
oligosaccharides
(HMOs)
are
the
third
most
important
nutrient
in
human
and
gold
standard
for
infant
nutrition.
Due
to
lack
of
an
enzyme
system
capable
utilizing
HMOs
intestine,
cannot
be
directly
utilized.
Instead,
they
function
as
natural
prebiotics,
participating
establishment
intestinal
microbiota
a
"bifidus
factor."
A
crucial
colonizer
early
intestine
is
