Ageing Research Reviews,
Год журнала:
2024,
Номер
104, С. 102616 - 102616
Опубликована: Дек. 5, 2024
Since
the
first
description
of
a
set
characteristics
aging
as
so-called
hallmarks
or
pillars
in
2013/2014,
these
have
served
guideposts
for
research
biology.
They
been
examined
range
contexts,
across
tissues,
response
to
disease
conditions
environmental
factors,
and
benchmark
various
anti-aging
interventions.
While
were
intended
capture
generalizable
aging,
they
are
derived
mostly
from
studies
rodents
humans.
Comparative
including
species
animal
tree
life
great
promise
reveal
new
insights
into
mechanistic
foundations
there
is
diversity
lifespan
age-associated
physiological
changes.
However,
it
unclear
how
well
defined
apply
diverse
species.
Here,
we
review
each
twelve
by
Lopez-Otin
2023
with
respect
availability
data
We
evaluate
current
methods
used
assess
their
potential
be
adapted
comparative
studies.
Not
unexpectedly,
find
that
supporting
described
restricted
humans
few
model
systems
no
available
many
clades.
Similarly,
not
all
can
easily
assessed
at
least
half
hallmarks,
today
employed
fill
this
gap
knowledge,
suggesting
prioritized
while
developed
study
remaining
hallmarks.
Probiotics and Antimicrobial Proteins,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 8, 2024
Abstract
Probiotics
are
pivotal
in
maintaining
or
restoring
the
balance
of
human
intestinal
microbiota,
a
crucial
factor
mitigating
diseases
and
preserving
host’s
health.
Exploration
into
Bacteroides
spp.
reveals
substantial
promise
their
development
as
next-generation
probiotics
due
to
profound
interaction
with
host
immune
cells
capability
regulate
microbiome’s
metabolism
by
significantly
impacting
metabolite
production.
These
beneficial
bacteria
exhibit
potential
ameliorating
various
health
issues
such
disorders,
cardiovascular
diseases,
behavioral
even
cancer.
Though
it’s
important
note
that
high
percentage
them
well
opportunistic
pathogens,
posing
risks
under
certain
conditions.
Studies
highlight
role
modifying
responses
improving
conditions
regulating
lymphocytes,
controlling
metabolism,
preventing
inflammation
The
safety
efficacy
strains
currently
scrutiny
European
Commission
for
authorization
food
processing,
marking
significant
step
towards
commercialization.
recent
advancements
bacterial
isolation
sequencing
methodologies,
coupled
integration
Metagenome-Assembled
Genomes
(MAGs)
binning
from
metagenomics
data,
continue
unveil
spp.,
aiding
broader
understanding
application
these
novel
disease
management.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Older
individuals
experience
increased
susceptibility
and
mortality
to
bacterial
infections,
but
the
underlying
etiology
remains
unclear.
Herein,
it
is
shown
that
aging‐associated
reduction
of
commensal
Parabacteroides
goldsteinii
(
P.
)
in
both
aged
mice
humans
critically
contributes
worse
outcomes
infection.
The
colonization
live
conferred
protection
against
infections.
Metabolomic
profiling
reveals
a
protective
compound,
apigenin,
generated
by
,
antagonizes
clearance
defects
mice.
AMP‐binding
protein
ampB
identified
as
key
gene
involved
apigenin
synthesis
using
homologous
recombination
bacteria.
Mechanistically,
binds
directly
potential
sites
on
Fgr
(M341
D404),
preventing
its
inhibitory
role
Vav1
phosphorylation,
therefore
promoting
activation
Cdc42/Rac1,
Arp2/3
expression
subsequent
actin
reorganization,
which
enhanced
phagocytosis
macrophages
Collectively,
findings
suggest
dysbiosis
gut
microbiota
may
impair
host
defense
mechanisms
increase
infections
older
adults
highlight
microbiota‐apigenin‐Fgr
axis
possible
route
ameliorate
antibacterial
defects.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
Despite
the
advantages
of
endoscopic
surgery
in
reducing
trauma
and
enhancing
recovery
for
breast
cancer
patients,
its
impact
on
gut
microbiota,
which
is
crucial
health
estrogen
metabolism,
remains
unclear.
Further
investigation
necessary
to
fully
understand
this
implications.
Between
June
December
2022,
fecal
samples
were
collected
from
20
patients
who
underwent
surgery.
The
microbiota
composition
was
determined
using
16S
rRNA
sequencing,
while
metabolites
analyzed
through
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS).
Bioinformatics
statistical
analyses
employed
identify
significant
alterations
microbial
taxa
abundance
assess
intergroup
differences.
These
included
t-tests
pairwise
comparisons,
one-way
ANOVA
multiple
group
chi-square
tests
categorical
data
analysis.
Endoscopic
subtly
changed
diversity
composition.
Post-surgery,
there
a
reduction
Lachnospiraceae,
Monoglobaceae
Firmicutes
Bacteroides
ratios.
Shifts
also
observed,
impacted
pathways
such
as
primary
bile
biosynthesis
Ascorbate
aldarate
with
PE(PGD1/18:1(9Z))
identified
key
differential
metabolite
that
increased
post-surgery.
Azasetron,
tyramine
glucuronide,
DL-DOPA,
phthalide,
acetophenazine,
aciclovir,
creatinine
bicarbonate,
4-oxo-L-proline
being
associated
distinct
bacterial
taxa.
Breast
undergoing
experience
shift
their
metabolic
profiles.
Therefore,
postoperative
management,
particular
focus
adjustment
patient
outcomes.
The
gut-brain
axis
(GBA)
denotes
the
dynamic
and
bidirectional
communication
system
that
connects
gastrointestinal
tract
central
nervous
(CNS).
This
review
explored
this
axis,
focusing
on
role
of
microbial
diversity
fitness
in
maintaining
health
preventing
neurodegeneration,
particularly
Alzheimer's
disease
(AD).
Gut
dysbiosis,
characterized
by
imbalance
populations
beneficial
harmful
bacteria,
has
been
associated
with
increased
systemic
inflammation,
neuroinflammation,
progression
AD
through
pathogenic
mechanisms
involving
amyloid
deposition,
tauopathy,
blood-brain
barrier
(BBB)
permeability.
Emerging
evidence
highlighted
therapeutic
potential
probiotics,
dietary
interventions,
intermittent
fasting
restoring
balance,
reducing
minimizing
neurodegenerative
risks.
Probiotics
synbiotics
are
promising
helping
improve
cognitive
function
metabolic
health,
while
patterns
like
Mediterranean
diet
were
linked
to
decreased
neuroinflammation
enhanced
communication.
Despite
significant
advancement,
further
research
is
needed
elucidate
specific
strains,
metabolites,
influencing
brain
health.
Future
studies
employing
longitudinal
designs
advanced
omics
technologies
essential
developing
targeted
microbiome-based
therapies
for
managing
AD-related
disorders.
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 590 - 590
Опубликована: Апрель 16, 2025
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
inflammatory
disease
characterized
by
the
inflammation
of
synovial
fluid.
The
incidence
cardiovascular
diseases
(CVDs)
increasing
in
RA
patients.
This
research
first
report
to
investigate
anti-arthritic
effect
avocado
peel
nutraceutical
(APN)
and
its
potential
mitigating
risk
associated
with
RA.
antioxidant
activity
phytochemical
composition
APN
were
assessed.
interaction
APN’s
active
compounds
protein
tyrosine
phosphatase
non-receptor
type
22
(PTPN22)
was
studied
using
molecular
docking.
impact
on
plasma
lipid
profile,
oxidative
markers,
indices
coronary
atherogenicity
as
CVD
markers
evaluated.
gene
expression
COX-2,
IL-6,
IL-1β,
IL-10,
TNF-α
liver
spleen
tissues
measured.
rat
gut
microbiota
profile
investigated
16S
rRNA
amplicon
sequencing.
exhibited
high
activity,
low
thrombogenicity
indices,
ratio
hypocholesterolemic
hypercholesterolemic
fatty
acids
indicating
cardioprotective
potential.
administration
led
reduction
stress
dyslipidemia,
markers.
downregulated
genes,
while
IL-10
significantly
upregulated
spleen.
Treatment
favorable
restoring
eubiosis
modulating
RA-associated
bacterial
taxa
linked
impaired
immune
function
cardiometabolic
diseases.
In
docking,
β-amyrin
ellagic
acid
showed
highest
binding
affinity
for
PTPN22.
may
represent
promising
approach
ameliorating
present
results
will
be
offering
foundation
future
in-depth
nutraceuticals
from
agriculture
by-products.
Additionally,
they
supporting
public
health
policies
aimed
at
preventing
controlling
rheumatoid
arthritis.
