The effect of deprescribing interventions on mortality and health outcomes in older people: An updated systematic review and meta‐analysis

British Journal of Clinical Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 20, 2024

Abstract Aims Previous systematic reviews suggest that deprescribing may improve survival, particularly in frail older people. Evidence is rapidly accumulating, suggesting a need for an updated review of the literature. Methods We 2016 and meta‐analysis to include studies published from inception 26 April 2024 specified databases. Studies which people had at least one medication deprescribed were included grouped by study designs targeted medications. The risk bias was assessed using Cochrane tool Newcastle‐Ottawa tool. Odds ratios (OR) or mean differences calculated as effect measures either Mantel–Haenszel generic inverse‐variance method with fixed‐ random‐effects meta‐analyses. primary outcome mortality. Secondary outcomes adverse drug withdrawal events, physical health, cognitive function, quality life on regimen. Subgroup analyses performed based age intervention types. Results A total 259 (reported 286 papers) this review. Deprescribing polypharmacy did not result significant reduction mortality both randomized (OR 0.96, 95% confidence interval [CI] 0.84–1.09) non‐randomized 0.70, CI 0.36–1.38). Further subgroup demonstrated young old (aged 65–79) 0.71, 0.51–0.99) when patient‐specific interventions applied 0.79, 0.63–0.99). Conclusions can be achieved potentially important benefits terms improved are initiated early old.

Язык: Английский

Factors associated with medication adherence among older adults with multimorbidity: A culture perspective

Geriatric Nursing, Год журнала: 2023, Номер 55, С. 297 - 303

Опубликована: Дек. 19, 2023

Язык: Английский