Human embryo editing against disease is unsafe and unproven — despite rosy predictions

Nature, Год журнала: 2025, Номер 637(8046), С. 554 - 556

Опубликована: Янв. 8, 2025

Язык: Английский

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Singaporean attitudes to cognitive enhancement: a cross-sectional survey

Journal of Medical Ethics, Год журнала: 2025, Номер unknown, С. jme - 110490

Опубликована: Фев. 25, 2025

Recent developments in genetic technologies have provided prospective parents with increasing opportunities to influence their future child’s phenotype. This study aimed understand public attitudes towards gene-based and services, a particular focus on improving educational outcomes. We conducted cross-sectional survey among Singaporean population (n=1438), adapting instrument previously used the US context. Our results suggested that Singaporeans had greater moral acceptance of, willingness use, services compared population. Among examined, use of polygenic embryo screening was considered more acceptable than gene editing. While these show some support for technologies, further research consultation multiple stakeholder groups is necessary determine whether such technology should be how it regulated.

Язык: Английский

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Patient perspectives after receiving simulated preconception polygenic risk scores (PRS) for family planning

Journal of Assisted Reproduction and Genetics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

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Polygenic Risk Scoring in Human Embryos

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Parents facing polygenic embryo scores: the ‘best choice of a best life’ and psychological counselling

Human Reproduction, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract Advances in reproductive medicine and genetic technologies now offer prospective parents the option to test IVF embryos for predispositions complex diseases, such as coronary heart disease psychiatric disorders, through polygenic embryo screening (PES). However, limited clinical data on its real-world use leaves facing decisions based probabilistic risk scores, requiring them weigh uncertain benefits against potential harms. While clinical, ethical, societal concerns regarding PES have been extensively discussed, psychological considerations received less attention. This paper highlights importance of decision aids part interventions, which are crucial helping navigate these choices make informed individual perceptions experiences. Additionally, determining how when disclose information children presents significant challenges families. Early disclosure may lead anxiety, while withholding could undermine trust later life. Psychological counseling is therefore an essential component supporting families sensitive decisions. offers opportunities reduce risks, it also introduces that require thoughtful consideration comprehensive support both children.

Язык: Английский

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The evolution of preimplantation genetic testing: where is the limit?

Reproductive BioMedicine Online, Год журнала: 2025, Номер 50(4), С. 104845 - 104845

Опубликована: Апрель 1, 2025

Язык: Английский

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A systematic review and meta-analysis of double trophectoderm biopsy and/or cryopreservation in PGT: balancing the need for a diagnosis against the risk of harm

Human Reproduction Update, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 13, 2024

To prevent the transfer of embryos affected by monogenic conditions and/or chromosomal defects, preimplantation genetic testing (PGT) requires trophectoderm biopsy and cryopreservation. In 2-6% biopsies, diagnosis may be inconclusive due to DNA amplification failure or low-quality results. these cases, a round re-warming, re-biopsy, re-cryopreservation is required obtain diagnosis. other when IVF centre starts providing PGT patients develop an indication because multiple failures, miscarriages birth child after IVF, cryopreserved untested warmed, biopsied, then re-vitrified. However, it still unclear whether manipulations reduce reproductive outcomes PGT.

Язык: Английский

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Polygenic risk scores and embryonic screening: considerations for regulation

Journal of Medical Ethics, Год журнала: 2024, Номер unknown, С. jme - 110145

Опубликована: Дек. 16, 2024

Polygenic risk scores (PRSs) have recently been used to inform reproductive decision-making in the context of embryonic screening. While this is yet be widespread, it contested and raises several challenges. This article provides an overview some ethical considerations that arise with using PRSs for embryo screening offers a series regulatory jurisdictions may wish permit future. These cover possible regulators tools, eligibility criteria, information education requirements need ongoing refinement relevant technology, research consultation.

Язык: Английский

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The current clinical applications of preimplantation genetic testing (PGT): acknowledging the limitations of biology and technology

Expert Review of Molecular Diagnostics, Год журнала: 2024, Номер 24(9), С. 767 - 775

Опубликована: Авг. 7, 2024

Preimplantation Genetic Testing (PGT) is a cutting-edge test used to detect genetic abnormalities in embryos fertilized through Medically Assisted Reproduction (MAR). PGT aims ensure that selected for transfer are free of specific conditions or chromosome abnormalities, thereby reducing chances unsuccessful MAR cycles, complicated pregnancies, and diseases future children.

Язык: Английский

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Preconception carrier screening and preimplantation genetic testing in the infertility management

Andrology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 21, 2024

Abstract Background Genetic testing serves as a valuable element of reproductive care, applicable at various stages the journey: (i) before pregnancy, when couple's genetic risk can be evaluated; (ii) embryo implantation, part in vitro fertilization (IVF) treatment, to ascertain several inherited or de novo genetic/chromosomal diseases transfer; (iii) during prenatal period, assess costitution fetus. Preconception carrier screening (CS) is test typically performed on couples planning pregnancy. The primary purpose CS identify at‐risk conceiving child affected by severe disorder with autosomal recessive X‐linked inheritance. Detection high through allows prospective parents informed their predisposition and improve decision‐making. These include undergoing IVF preimplantation (PGT) donor gametes, diagnosis, adoption, remaining childless, taking no actions. Both presence gene (PGT‐M) chromosomal status (PGT‐A) comprehensively assessed modern approaches. Objectives We provide review PGT applications equip healthcare providers up‐to‐date information regarding opportunities complexities. Results Discussion use currently considered most effective intervention for avoiding both an pregnancy whilst using autologous gametes known increased risk, abnormalities. As our understanding component pathological conditions increases, number tested disorders will expand, offering more thorough assessment one's Nevertheless, implementation development this field must accompanied scientific ethical considerations ensure approach best long‐term interests individuals society, promoting justice autonomy preserving parenthood system. Conclusion combination aligns principles personalized medicine care tailored individual's makeup.

Язык: Английский

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