Human papillomavirus circulating tumor DNA assays as a mechanism for head and neck cancer equity in rural regions of the United States DOI Creative Commons
Melina J. Windon, Catherine T. Haring

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Май 8, 2024

The rates of human papillomavirus-positive oropharyngeal cancer (HPV-OPC) are rising worldwide and in the United States, particularly rural regions including Appalachia. Rural areas face unique health challenges resulting higher incidence mortality rates, this includes HPV-OPC. recent advent highly sensitive liquid biopsies for non-invasive detection HPV-OPC recurrence (circulating tumor HPV DNA, ctDNA) has been swiftly adopted as part surveillance paradigms. Though knowledge gaps persist regarding its use clinical trials ongoing, ease collection cost-effectiveness ctDNA make it more accessible survivors than usual methods frequent exams imaging. Herein, we discuss how implementing assays States provide one poignant example can improve care equity.

Язык: Английский

Epidemiology of HPV-associated cancers past, present and future: towards prevention and elimination DOI
Talía Malagón, Eduardo L. Franco, Romina A. Tejada

и другие.

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(7), С. 522 - 538

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

33
Global, regional and national burdens of cardiovascular disease attributable to secondhand smoke from 1990–2019: an age-period-cohort analysis DOI Creative Commons
Hong Jiang, Zeye Liu, Peijian Wei

и другие.

Open Heart, Год журнала: 2025, Номер 12(1), С. e003079 - e003079

Опубликована: Фев. 1, 2025

Background Over the past three decades, significant disparities in global burden of cardiovascular disease (CVD) have been observed, particularly CVD attributed to secondhand smoke. However, a comprehensive understanding trends and their interaction with smoke remains inadequate. Methods Using Global Burden Disease data (1990–2019), an age-period-cohort analysis examined temporal mortality among smoke-exposed populations, considering age, period cohort interactions. Results 30-year period, number deaths increased substantially, from 432.6 thousand 1990 (95% UI: 357.4–508.3) 598.5 2019 489.7–713.5), representing 38.4% increase 26.8%–49.5%). In 2019, accounted for 45.9% all attributable both sexes globally. Among these deaths, ischaemic heart predominated, accounting 66.4% cases, compared stroke. The distribution by sex revealed slightly lower percentage males (46.5%) than females (53.5%). Age-period-cohort models show overall decline due over 30 years, regional, subtype variations. Notably, higher Sociodemographic Index (SDI) correlated greater reduction mortality, exhibiting 39.1% decrease high SDI areas 35.6%–42.3%), stark contrast minimal change observed low (0.1%, 95% −52.4%–62.2%). Conclusions This study highlights importance as modifiable risk. Further research is needed understand across development levels, subtypes.

Язык: Английский

Процитировано

2
Global burden of head and neck cancers from 1990 to 2019 DOI Creative Commons
Tianjiao Zhou, Weijun Huang, Xiaoting Wang

и другие.

iScience, Год журнала: 2024, Номер 27(3), С. 109282 - 109282

Опубликована: Фев. 20, 2024

Head and neck cancer (HNC) exerts a significant healthcare burden worldwide. Insufficient data impedes comprehensive understanding of its global impact. Through analysis the 2019 Global Burden Disease (GBD) database, our secondary investigation unveiled surging incidence HNC, yet decline in associated mortality disability-adjusted life years (DALYs) owing to enhanced prognosis. Particularly noteworthy is higher escalation among females compared males. Effective resource allocation, meticulous control risk factors, tailored interventions are imperative curtail rates young individuals afflicted with HNC underprivileged regions, as well elderly grappling thyroid cancer.

Язык: Английский

Процитировано

14
Epidemiology of oral cancer in South and South‐East Asia: Incidence and mortality DOI
Adalberto Miranda‐Filho, Saman Warnakulasuriya

Oral Diseases, Год журнала: 2024, Номер 30(8), С. 4847 - 4854

Опубликована: Март 7, 2024

Abstract Introduction This study provides an epidemiological description of cancer in the lip, oral cavity, and oropharynx South South‐East Asia region. Methods The number new cases deaths was extracted from GLOBOCAN 2020 CI5 series. We present age‐standardized incidence mortality rates per 100,000 inhabitants. To assess temporal trends, we estimated annual percent change. Results (ASR) for lip cavity were highest Taiwan (30.2), Sri Lanka (16.5), India (14.8), Pakistan (13.2) among males. For oropharyngeal cancer, found (4.7), Bangladesh, Lanka, (4.3, 2.9, 2.6, respectively). Incidence consistently higher males compared to females. Overall, trends either stable or decreasing most populations evaluated. In India, increase contrasted with a decline females over period. Conclusion are globally. Our results suggest optimistic trend reduction region, despite Indian

Язык: Английский

Процитировано

14
Changing Landscape of Head and Neck Squamous Cell Carcinoma and Nasopharyngeal Carcinoma Treatment and Survival Trends in Thailand: A 13-Year Multicenter Retrospective Study of Patients DOI Creative Commons
Nuttapong Ngamphaiboon, Arunee Dechaphunkul, Chanida Vinayanuwattikun

и другие.

JCO Global Oncology, Год журнала: 2025, Номер 11

Опубликована: Янв. 1, 2025

PURPOSE The incidence and survival rates of head neck squamous cell carcinoma (HNSCC) nasopharyngeal (NPC) vary globally, influenced by factors such as ethnicity, lifestyle, health care systems. METHODS A retrospective analysis was conducted on patients with HNSCC treated between 2008 2020 in four major Thai academic cancer centers, using a multidisciplinary multicenter database. study focused the evolution patient characteristics, changes, treatment landscape alterations over time. RESULTS Among 6,319 patients, most common primary sites were nasopharynx (33%), oral cavity (23%), oropharynx (17%), larynx (15%), hypopharynx (8%). An increase human papillomavirus–related oropharyngeal noted, from 13% to 42% 2019-2020. majority presented locally advanced (LA) stages (IVa/b: 50%, III: 26%). Chemoradiotherapy (54%) surgery (24%) main treatments, cisplatin (79%) being commonly used chemoradiation. Overall (OS) improved annually across all subsites, correlating an intensity-modulated radiotherapy (IMRT) use, 25% 90% median follow-up duration 4.59 years, minimum 2.75 years. Patients IMRT had significantly longer OS compared those non-IMRT techniques, both NPC non-NPC ( P < .001). CONCLUSION To our knowledge, this is largest Thailand that demonstrates increasing outcomes NPC, despite presenting LA stages. use may be contributing patients.

Язык: Английский

Процитировано

1
An Assessment of Young Adults’ Awareness and Knowledge Related to the Human Papillomavirus (HPV), Oropharyngeal Cancer, and the HPV Vaccine DOI Open Access

Eric N Davis,

Philip C. Doyle

Cancers, Год журнала: 2025, Номер 17(3), С. 344 - 344

Опубликована: Янв. 21, 2025

Background/Objectives: The human papillomavirus (HPV) is a prevalent sexually transmitted infection that known cause of morbidities such as genital warts and cancers the cervix, anus, oropharynx. Non-cervical HPV-related have been developing problem in North America, increasing incidence by up to 225% some instances over span two decades. Methods: This study investigated levels awareness knowledge HPV, oropharyngeal cancer (OPC), HPV vaccine using self-administered web-based survey designed specifically for this research. University students (n = 1005) aged 18–30 completed 42-item questionnaire included demographic information, questions, series “true/false/I don’t know” questions. Results: data gathered revealed participants had relatively high awareness. However, many respondents significant gaps their OPC, vaccine. Collectively, indicate value vaccination may place younger individuals at risk infections. Conclusions: Although level concerning was observed, suggest further efforts are necessary educate young adults. While all factors cannot be reduced, present guide future directed toward better education on related health concerns associated risks.

Язык: Английский

Процитировано

1
Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives DOI Open Access
Alan Soo Beng Khoo, Michael Boyer, Zuhayr Jafri

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2798 - 2798

Опубликована: Фев. 28, 2024

Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck (HNSCC), involves the palatine tonsils, soft palate, base tongue, uvula, with ability to spread adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated oropharynx (HPV+OPSCC) are yet be established. In this article, we summarise our current understanding pathogenesis HPV+OPSCC, intrinsic role immune system, ICI clinical trials, potential small molecule immunotherapy in HPV+OPSCC.

Язык: Английский

Процитировано

5
From infection to immortality: The role of HPV and telomerase in head and neck cancer DOI Creative Commons
Silvia Giunco, Annarosa Del Mistro, Marzia Morello

и другие.

Oral Oncology, Год журнала: 2025, Номер 161, С. 107169 - 107169

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

0
Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets DOI Creative Commons
Guangpeng Gao, Xindi Zhang

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Язык: Английский

Процитировано

0
Trends in Human Papillomavirus-Related Health Burden in Greece from 1996 to 2021 with a Focus on Cervical and Lip, Oral Cavity, and Pharyngeal Cancer DOI Creative Commons
Georgios Tampakoudis, Olympia E. Anastasiou

Pathogens, Год журнала: 2025, Номер 14(2), С. 197 - 197

Опубликована: Фев. 16, 2025

This study aimed to evaluate the burden of HPV-related hospitalization and mortality in Greece, with a focus on invasive cervical cancer lip, oral cavity, pharyngeal (LOCP) cancers. A retrospective query using data from Greek Statistical Office Eurostat was executed. The included hospital admission standardized rates (SDRs) dysplasia cervical, vulvar, vaginal; anal; penile; LOCP rate for decreased over time, exhibiting sharp decrease after 2010, while 2011, preceded by sustained increase 1996. HPV-attributable diseases total showed declining tendency between 2013 2017. SDR due slightly decreasing trend Greece European Union, increasing but Union. decline disease especially dysplasia, also EU, are indications positive public health impact screening programs implementation HPV vaccination.

Язык: Английский

Процитировано

0