Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Май 8, 2024
The
rates
of
human
papillomavirus-positive
oropharyngeal
cancer
(HPV-OPC)
are
rising
worldwide
and
in
the
United
States,
particularly
rural
regions
including
Appalachia.
Rural
areas
face
unique
health
challenges
resulting
higher
incidence
mortality
rates,
this
includes
HPV-OPC.
recent
advent
highly
sensitive
liquid
biopsies
for
non-invasive
detection
HPV-OPC
recurrence
(circulating
tumor
HPV
DNA,
ctDNA)
has
been
swiftly
adopted
as
part
surveillance
paradigms.
Though
knowledge
gaps
persist
regarding
its
use
clinical
trials
ongoing,
ease
collection
cost-effectiveness
ctDNA
make
it
more
accessible
survivors
than
usual
methods
frequent
exams
imaging.
Herein,
we
discuss
how
implementing
assays
States
provide
one
poignant
example
can
improve
care
equity.
Acta Oncologica,
Год журнала:
2025,
Номер
64, С. 276 - 283
Опубликована: Фев. 17, 2025
Background
and
purpose:
Distinguishing
branchial
cleft
cysts
(BrCCs)
from
cystic
metastases
of
human
papillomavirus
(HPV)
positive
tonsillar
or
base
tongue
squamous
cell
carcinoma
cancer
unknown
primary
(CUP)
is
challenging.
Fine
needle
aspiration
cytology
(FNAC)
metastasis
can
be
nonrepresentative,
while
reactive
cells
BrCC
atypical.
It
unclear
whether
benign
characteristics
the
absence
HPV-DNA
in
FNAC
enhance
distinguishing
a
metastasis;
therefore,
we
investigated
here.
Patients/materials
methods:
Morphology
were
reevaluated
preoperatively
correlated
to
final
diagnosis
304
CUP
patients
at
Karolinska
University
Hospital
during
2016-2023.
Results
interpretation:
All
176
cases
finally
diagnosed
as
negative
preoperative
FNAC.
was
present
100/128
(78.1%)
with
solitary
neck
3/3
CUPs
separately
on
surgical
specimens,
which
distributed
40/58
(69.0%)
CUP,
40/41
(97.6%)
cancer,
21/22
(95.5%)
2/2
uterine
cervical
0/5
non-HPV-related
cancers.
Interpretation:
only
malignant
masses
HPV-related
tumors
CUP.
The
data
suggest
that
analysis
enhances
diagnostics
neck.
A
morphology
indicated
BrCC,
an
aspirate
irrespective
suggested
To
investigate
the
efficacy
and
safety
of
local
intra-arterial
chemotherapy
combined
with
immune
checkpoint
inhibitors
in
treatment
unresectable
head
neck
squamous
cell
carcinoma
(HNSCC).
A
retrospective
analysis
was
conducted
on
clinical
data
eight
patients
diagnosed
HNSCC
at
our
hospital
from
January
to
December
2023.
All
were
by
pathological
diagnosis
treated
inhibitors.
The
overall
response
rate
(ORR),
progression-free
survival
(PFS),
(OS),
adverse
reactions
observed.
study
cohort
consisted
seven
men
one
woman,
a
median
age
58.4
±
13.1
years.
Five
stage
IVA,
IVB,
two
IVC.
One
patient
lost
follow-up,
among
7
complete
data,
ORR
85.7%.
PFS
OS
population
not
achieved,
tolerated
well
no
significant
effects.
Local
is
an
important
future
exploration
direction
for
HNSCC.
Journal of Medical Virology,
Год журнала:
2025,
Номер
97(3)
Опубликована: Март 1, 2025
Oral
HPV
DNA
and
circulating
tumor
(ct)
in
plasma
were
evaluated
as
potential
biomarkers
for
HPV-associated
head
neck
cancer
(HNC).
Samples
from
HNC
patients
(n
=
132),
including
23
oropharyngeal
cancers
(OPC),
non-HNC
controls
10)
analyzed.
status
was
determined
using
a
multiplex
bead-based
test
(E7-MPG)
applied
to
formalin-fixed
paraffin-embedded
(FFPE)
tissues
90),
141),
gargle
samples
oral
swabs
142).
detected
25.8%
of
tissues,
12%
samples,
20.6%
gargles
7%
with
HPV16
the
most
prevalent
genotype.
Among
OPC
cases,
found
71.4%
FFPE
samples.
High
concordance
observed
between
paired
(91.3%)
or
(95.2%),
moderate
(59.1%).
Gargle
alone
demonstrated
100%
detection
rate
HPV16-positive
OPC,
regardless
cT
stage,
outperforming
(86.7%).
Combined
analyses
all
HPV-positive
cases
(7/7)
at
early
cT1
stage.
These
findings
highlight
limited
involvement
non-oropharyngeal
compared
support
minimally
invasive
diagnostic
tools
detecting
OPC.
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 245 - 264
Опубликована: Март 7, 2025
Palliative
care
is
an
approach
that
aims
to
improve
the
quality
of
life
for
patients
with
serious,
incurable
illnesses
by
focusing
on
symptom
relief.
Oropharyngeal
cancer
often
diagnosed
at
advanced
stages
and
presents
a
range
physical
psychological
symptoms.
This
chapter
synthesize
information
regarding
oropharyngeal
its
through
palliative
care,
emphasizing
importance
interdisciplinary
perspective
alleviating
symptoms
such
as
pain,
difficulty
swallowing,
breathing
problems.
Adequate
nutritional
support
crucial,
given
significant
impact
disease
patient's
food
intake
nutrition.
Furthermore,
need
public
policies
ensure
equitable
access
integration
into
healthcare
system
should
be
emphasized.
It
is,
therefore,
evident
investing
in
education
training
professionals
this
type
global
health.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 10, 2023
Oral
cancer,
a
predominant
malignancy
in
developing
nations,
represents
global
health
challenge
with
five-year
survival
rate
below
50%.
Nonetheless,
substantial
reductions
both
its
incidence
and
mortality
rates
can
be
achieved
through
early
detection
appropriate
treatment.
Crucial
to
these
treatment
plans
prognosis
predictions
is
the
identification
of
pathological
type
oral
cancer.Toward
this
end,
fiber-optic
Raman
spectroscopy
emerges
as
an
effective
tool.
This
study
combines
technology
deep
learning
algorithms
develop
portable
intelligent
prototype
for
case
analysis.
We
propose,
first
time,
multi-task
network
(MTN)
classification
model
that
utilizes
shared
backbone
simultaneously
achieve
different
clinical
staging
histological
grading
diagnoses.The
developed
demonstrated
accuracy
94.88%,
94.57%,
94.34%
tumor
staging,
lymph
node
grading,
respectively.
Its
sensitivity,
specificity,
compare
closely
gold
standard:
routine
histopathological
examination.Thus,
proposed
has
great
potential
rapid,
non-invasive,
label-free
diagnosis
cancer.
