The role and function of lncRNA in ageing-associated liver diseases DOI Creative Commons
Peyman Kheirandish Zarandi, Mohsen Ghiasi, Mohammad Heiat

и другие.

RNA Biology, Год журнала: 2024, Номер 22(1), С. 1 - 8

Опубликована: Дек. 19, 2024

Liver diseases are a significant global health issue, characterized by elevated levels of disorder and death. The substantial impact ageing on liver their prognosis is evident. Multiple processes involved in the process, which ultimately leads to functional deterioration this organ. process not only renders more susceptible but also compromises integrity other organs due liver's critical function metabolism regulation. A growing body research suggests that long non-coding RNAs (lncRNAs) play role majority pathophysiological pathways. They regulate gene expression through variety interactions with microRNAs (miRNAs), messenger (mRNAs), DNA, or proteins. LncRNAs exert major influence progression age-related regulation cell proliferation, necrosis, apoptosis, senescence, metabolic reprogramming. concise overview current understanding lncRNAs potential development will be provided mini-review.

Язык: Английский

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging DOI
Shuai Ma,

Zhejun Ji,

Bin Zhang

и другие.

Cell, Год журнала: 2024, Номер 187(24), С. 7025 - 7044.e34

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

13
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases DOI
Zeming Wu, Jing Qu, Guang‐Hui Liu

и другие.

Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(12), С. 979 - 1000

Опубликована: Окт. 3, 2024

Язык: Английский

Процитировано

8
Ethical concerns in aging research: perspectives of global frontline researchers DOI
Yaojin Peng,

Lulu Ding,

Zhenyu Xiao

и другие.

Science China Life Sciences, Год журнала: 2024, Номер 67(10), С. 2149 - 2156

Опубликована: Июль 19, 2024

Язык: Английский

Процитировано

6
Exploring the heterogeneous targets of metabolic aging at single-cell resolution DOI
Shuhui Sun, Mengmeng Jiang, Shuai Ma

и другие.

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

5
CRISPR-based screening pinpoints H2AZ1 as a driver of senescence in human mesenchymal stem cells DOI Creative Commons

Ming-Heng Li,

Xiaoyu Jiang,

Yaobin Jing

и другие.

Protein & Cell, Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Язык: Английский

Процитировано

4
Assessment of the Capability of Mesenchymal Stem Cells and/or Pyrroloquinoline Quinone in Compensating the Age-Related Dysfunctions of AMP-Activated Protein Kinase Pathway in Wistar Rats DOI

Kamal M. Al Nishilli,

Emad M. El Zayat,

Sherein S. Abdelgayed

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

0
Assessment of the Capability of Mesenchymal Stem Cells and/or Pyrroloquinoline Quinone in Compensating the Age-related Dysfunctions of AMP-Activated Protein Kinase Pathway in Wistar Rats DOI Creative Commons

Kamal M. Al Nishilli,

Emad M. El Zayat,

Sherein S. Abdelgayed

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Abstract Aging is characterized by a decline in physiological functions and an increased susceptibility to age-related diseases. This study investigates the therapeutic potential of mesenchymal stem cells (MSCs) pyrroloquinoline quinone (PQQ), individually combination, counteract aging-related declines, with specific focus on their modulation AMP-activated protein kinase (AMPK) pathway, key regulator cellular energy homeostasis stress response. was induced thirty-seven female rats using D-galactose, simulating metabolic imbalances oxidative characteristic aging. The experimental groups included controls, aged without treatment, treated MSCs, PQQ, or combined MSC-PQQ regimen. MSC homing analyses Behavioral assessments, assays, gene expression profiling, histopathological evaluations were conducted provide multidimensional view treatment efficacy. confirmed successful tissue localization repair, underscoring regenerative capacity MSCs. Remarkably, therapy (APQQST) markedly improved anxiety-related behaviors, evidenced rearing grooming activities (p < 0.01). Oxidative biomarkers supported these findings; exhibited significantly reduced malondialdehyde (MDA) levels elevated antioxidant defenses, including glutathione (GSH) peroxidase (GPX) Gene analysis highlighted beneficial upregulation genes such as LKB1, PFKFB3, TSC2, HMGR, crucial for response, combination showing most pronounced effects. Furthermore, assessments underscored significant liver recovery groups, particularly (APQQST), minimal vacuolar degeneration restored hepatic architecture These findings highlight synergistic effects MSCs PQQ mitigating behavioral, molecular, aspects aging, promising agents promoting healthy aging offering foundation future translational research clinical applications.

Язык: Английский

Процитировано

0
Combined Exposure of Sleep Deprivation and Environmental Particulate Matter Drives Aging in Multiple Systems DOI

Yu Lu,

Chihang Zhang,

Wu B

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 491, С. 137914 - 137914

Опубликована: Март 13, 2025

Язык: Английский

Процитировано

0
Proteomic and phosphoproteomic signatures of aging mouse liver DOI
Rodrigo Mohallem, Allison J. Schaser, Uma K. Aryal

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
Tea polyphenols ameliorates insulin resistance and inflammation by modulating macrophage polarization via JAK2/STAT3 pathway in aged T2DM combined with NAFLD rats DOI
Xi Wang,

Shuangzhi Chen,

Chengyang Li

и другие.

Journal of Functional Foods, Год журнала: 2025, Номер 127, С. 106727 - 106727

Опубликована: Март 18, 2025

Язык: Английский

Процитировано

0