RNA Biology,
Год журнала:
2024,
Номер
22(1), С. 1 - 8
Опубликована: Дек. 19, 2024
Liver
diseases
are
a
significant
global
health
issue,
characterized
by
elevated
levels
of
disorder
and
death.
The
substantial
impact
ageing
on
liver
their
prognosis
is
evident.
Multiple
processes
involved
in
the
process,
which
ultimately
leads
to
functional
deterioration
this
organ.
process
not
only
renders
more
susceptible
but
also
compromises
integrity
other
organs
due
liver's
critical
function
metabolism
regulation.
A
growing
body
research
suggests
that
long
non-coding
RNAs
(lncRNAs)
play
role
majority
pathophysiological
pathways.
They
regulate
gene
expression
through
variety
interactions
with
microRNAs
(miRNAs),
messenger
(mRNAs),
DNA,
or
proteins.
LncRNAs
exert
major
influence
progression
age-related
regulation
cell
proliferation,
necrosis,
apoptosis,
senescence,
metabolic
reprogramming.
concise
overview
current
understanding
lncRNAs
potential
development
will
be
provided
mini-review.
Nucleic Acids Research,
Год журнала:
2024,
Номер
52(19), С. 11481 - 11499
Опубликована: Сен. 11, 2024
Dysfunction
of
the
ribosome
manifests
during
cellular
senescence
and
contributes
to
tissue
aging,
functional
decline,
development
aging-related
disorders
in
ways
that
have
remained
enigmatic.
Here,
we
conducted
a
comprehensive
CRISPR-based
loss-of-function
(LOF)
screen
ribosome-associated
genes
(RAGs)
human
mesenchymal
progenitor
cells
(hMPCs).
Through
this
approach,
identified
ribosomal
protein
L22
(RPL22)
as
foremost
RAG
whose
deficiency
mitigates
effects
senescence.
Consequently,
absence
RPL22
delays
hMPCs
from
becoming
senescent,
while
an
excess
accelerates
process.
Mechanistically,
found
senescent
hMPCs,
accumulates
within
nucleolus.
This
accumulation
triggers
cascade
events,
including
heterochromatin
decompaction
with
concomitant
degradation
key
proteins,
specifically
1γ
(HP1γ)
KRAB-associated
1
(KAP1).
Subsequently,
RPL22-dependent
breakdown
stimulates
transcription
RNAs
(rRNAs),
triggering
In
summary,
our
findings
unveil
novel
role
for
nucleolar
destabilizer
driver
senescence,
shedding
new
light
on
intricate
mechanisms
underlying
aging
