Brain Iron Homeostasis and Mental Disorders
Antioxidants,
Год журнала:
2023,
Номер
12(11), С. 1997 - 1997
Опубликована: Ноя. 13, 2023
Iron
plays
an
essential
role
in
various
physiological
processes.
A
disruption
iron
homeostasis
can
lead
to
severe
consequences,
including
impaired
neurodevelopment,
neurodegenerative
disorders,
stroke,
and
cancer.
Interestingly,
the
link
between
mental
health
disorders
has
not
received
significant
attention.
Therefore,
our
understanding
of
metabolism
context
psychological
diseases
is
incomplete.
In
this
review,
we
aim
discuss
pathologies
potential
mechanisms
that
relate
associated
disorders.
We
propose
hypothesis
maintaining
brain
support
neuronal
functions
by
impacting
key
enzymatic
activities
during
neurotransmission,
redox
balance,
myelination.
conclusion,
review
highlights
importance
investigating
relationship
trace
element
nutrition
pathological
process
focusing
on
iron.
This
nutritional
perspective
offer
valuable
insights
for
clinical
treatment
Язык: Английский
Enhancing Zinc Uptake through Dual-Modification of Cicer arietinum Protein
Journal of Food Biochemistry,
Год журнала:
2023,
Номер
2023, С. 1 - 26
Опубликована: Окт. 31, 2023
Zinc
is
crucial
for
physiological
processes;
however,
deficiency
persists
globally.
Binding
zinc
to
plant
proteins
enhances
absorption,
minimizing
toxicity
risks
and
offering
a
potential
solution
deficiency.
Mineral
binding
efficiency
of
the
unmodified
protein
limited;
hence,
dual
modification
(succinylation
ultrasonication)
potentially
used
achieve
higher
efficiency.
Enhancing
uptake
cellular
health
due
its
vital
roles
in
various
biological
processes
including
enzymatic
activity,
DNA
repair,
immune
function,
antioxidant
defense,
hormone
regulation,
brain
signaling,
growth,
gene
expression,
reproduction.
Therefore,
this
research
aimed
develop
chickpea
protein-zinc
complex
evaluate
influence
on
their
physiochemical,
bioavailability,
mineral
attributes.
Succinylation
exhibited
significant
improvements
water-holding
capacity
by
28.73%,
oil-holding
34.09%,
solubility
5.46%
as
compared
native
complex.
bioavailability
increased
8.32%,
there
were
notable
increases
2.10%,
retention
5.80%,
transport
3.96%,
respectively.
Furthermore,
approach
resulted
decrease
particle
size
complex,
with
substantial
reduction
73.25%
an
zeta
value
−21
mV
succinylated
As
well,
concurrently
led
decline
48.04%
sulfhydryl
(SH)
content,
coupled
marked
increase
21.92%
surface
hydrophobicity.
In
addition,
uptake,
retention,
further
enhanced
1.89,
3.34,
4.8%
through
modification.
Our
findings
highlight
that
shows
promising
strategy
enhancing
techno-functional
characteristics,
zinc,
which
could
be
better
platform
developing
vegan
foods.
Язык: Английский
Progressive Hippocampal Senescence and Persistent Memory Deficits in Traumatic Brain Injury: A Role of Delayed Testosterone
Jacob E. Exline,
Michael Volyanyuk,
Krista Lotesto
и другие.
Опубликована: Янв. 1, 2025
Язык: Английский
Progressive hippocampal senescence and persistent memory deficits in traumatic brain Injury: A role of delayed testosterone
Jacob E. Exline,
Michael Volyanyuk,
Krista Lotesto
и другие.
Brain Research,
Год журнала:
2025,
Номер
unknown, С. 149611 - 149611
Опубликована: Март 1, 2025
Язык: Английский
Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury
Acta Neuropathologica Communications,
Год журнала:
2023,
Номер
11(1)
Опубликована: Июль 18, 2023
Repetitive
mild
traumatic
brain
injury
(r-mTBI)
has
increasingly
become
recognised
as
a
risk
factor
for
the
development
of
neurodegenerative
diseases,
many
which
are
characterised
by
tau
pathology,
metal
dyshomeostasis
and
behavioural
impairments.
We
aimed
to
characterise
status
involvement
iron
in
repetitive
controlled
cortical
impact
(5
impacts,
48
h
apart)
3-month-old
C57Bl6
mice
at
chronic
(12-month)
time
point.
performed
battery
tests,
neurodegeneration-associated
proteins
(tau
tau-regulatory
proteins,
amyloid
precursor
protein
iron-regulatory
proteins)
via
western
blot;
levels
using
bulk
inductively
coupled
plasma-mass
spectrometry
(ICP-MS).
report
significant
changes
various
ipsilateral
following
five
but
not
single
injury,
increases
contralateral
iron,
zinc
copper
impacts.
There
was
no
evidence
pathology
or
although
some
were
observed
injury.
Five
impacts
resulted
gait
deficits,
anhedonia
cognitive
deficits
9-12
months
post-injury,
effects
seen
To
best
our
knowledge,
we
first
describe
metals
mouse
model
r-mTBI,
providing
strong
indication
towards
an
overall
increase
(and
other
metals)
phase
r-mTBI.
These
results
bring
question
relevance
highlight
dysregulation
and/or
progression
neurodegeneration
may
lead
new
therapeutic
approaches
future.
Язык: Английский
Research Progress of Ionomics in Central Nervous System Diseases
Journal of Clinical Personalized Medicine,
Год журнала:
2024,
Номер
03(04), С. 2161 - 2167
Опубликована: Янв. 1, 2024
Язык: Английский
AGEING RESEARCH REVIEWS (ARR-D-24-01334R1) Metabolic dysfunction contributes to mood disorders after traumatic brain injury
Ageing Research Reviews,
Год журнала:
2024,
Номер
104, С. 102652 - 102652
Опубликована: Дек. 31, 2024
Язык: Английский
Elemental Mapping in a Preclinical Animal Model Reveals White Matter Copper Elevation in the Acute Phase of Central Nervous System Trauma
ACS Chemical Neuroscience,
Год журнала:
2023,
Номер
14(18), С. 3518 - 3527
Опубликована: Сен. 11, 2023
Understanding
the
chemical
events
following
trauma
to
central
nervous
system
could
assist
in
identifying
causative
mechanisms
and
potential
interventions
protect
neural
tissue.
Here,
we
apply
a
partial
optic
nerve
transection
model
of
injury
rats
use
synchrotron
X-ray
fluorescence
microscopy
(XFM)
perform
elemental
mapping
metals
(K,
Ca,
Fe,
Cu,
Zn)
other
related
elements
(P,
S,
Cl)
white
matter
tracts.
The
spatial
precision
allow
us
obtain
previously
unattained
resolution
changes
response
primary
subsequent
secondary
effects.
We
observed
significant
elevation
Cu
levels
at
multiple
time
points
injury,
both
site
tissue
near
vulnerable
damage,
as
well
Cl,
K,
P,
Ca.
Our
results
suggest
widespread
metal
dyshomeostasis
that
altered
homeostasis
may
be
specific
event
injury.
findings
highlight
point
intervention
limiting
damage
Язык: Английский