Elemental Mapping in a Preclinical Animal Model Reveals White Matter Copper Elevation in the Acute Phase of Central Nervous System Trauma DOI
Cameron W. Evans,

Abigail Egid,

Somayra Mamsa

et al.

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(18), P. 3518 - 3527

Published: Sept. 11, 2023

Understanding the chemical events following trauma to central nervous system could assist in identifying causative mechanisms and potential interventions protect neural tissue. Here, we apply a partial optic nerve transection model of injury rats use synchrotron X-ray fluorescence microscopy (XFM) perform elemental mapping metals (K, Ca, Fe, Cu, Zn) other related elements (P, S, Cl) white matter tracts. The spatial precision allow us obtain previously unattained resolution changes response primary subsequent secondary effects. We observed significant elevation Cu levels at multiple time points injury, both site tissue near vulnerable damage, as well Cl, K, P, Ca. Our results suggest widespread metal dyshomeostasis that altered homeostasis may be specific event injury. findings highlight point intervention limiting damage

Language: Английский

Brain Iron Homeostasis and Mental Disorders DOI Creative Commons
Qiong Wu,

Qiuyang Ren,

Jingsi Meng

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 1997 - 1997

Published: Nov. 13, 2023

Iron plays an essential role in various physiological processes. A disruption iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders has not received significant attention. Therefore, our understanding of metabolism context psychological diseases is incomplete. In this review, we aim discuss pathologies potential mechanisms that relate associated disorders. We propose hypothesis maintaining brain support neuronal functions by impacting key enzymatic activities during neurotransmission, redox balance, myelination. conclusion, review highlights importance investigating relationship trace element nutrition pathological process focusing on iron. This nutritional perspective offer valuable insights for clinical treatment

Language: Английский

Citations

15
Enhancing Zinc Uptake through Dual-Modification of Cicer arietinum Protein DOI Open Access
Nikhil Dnyaneshwar Patil, Aarti Bains, Kandi Sridhar

et al.

Journal of Food Biochemistry, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 26

Published: Oct. 31, 2023

Zinc is crucial for physiological processes; however, deficiency persists globally. Binding zinc to plant proteins enhances absorption, minimizing toxicity risks and offering a potential solution deficiency. Mineral binding efficiency of the unmodified protein limited; hence, dual modification (succinylation ultrasonication) potentially used achieve higher efficiency. Enhancing uptake cellular health due its vital roles in various biological processes including enzymatic activity, DNA repair, immune function, antioxidant defense, hormone regulation, brain signaling, growth, gene expression, reproduction. Therefore, this research aimed develop chickpea protein-zinc complex evaluate influence on their physiochemical, bioavailability, mineral attributes. Succinylation exhibited significant improvements water-holding capacity by 28.73%, oil-holding 34.09%, solubility 5.46% as compared native complex. bioavailability increased 8.32%, there were notable increases 2.10%, retention 5.80%, transport 3.96%, respectively. Furthermore, approach resulted decrease particle size complex, with substantial reduction 73.25% an zeta value −21 mV succinylated As well, concurrently led decline 48.04% sulfhydryl (SH) content, coupled marked increase 21.92% surface hydrophobicity. In addition, uptake, retention, further enhanced 1.89, 3.34, 4.8% through modification. Our findings highlight that shows promising strategy enhancing techno-functional characteristics, zinc, which could be better platform developing vegan foods.

Language: Английский

Citations

13
Progressive Hippocampal Senescence and Persistent Memory Deficits in Traumatic Brain Injury: A Role of Delayed Testosterone DOI

Jacob E. Exline,

Michael Volyanyuk,

Krista Lotesto

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Progressive hippocampal senescence and persistent memory deficits in traumatic brain Injury: A role of delayed testosterone DOI Creative Commons

Jacob E. Exline,

Michael Volyanyuk,

Krista Lotesto

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149611 - 149611

Published: March 1, 2025

Language: Английский

Citations

0
Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury DOI Creative Commons
Sydney M. A. Juan, Maria Daglas, Phan H. Truong

et al.

Acta Neuropathologica Communications, Journal Year: 2023, Volume and Issue: 11(1)

Published: July 18, 2023

Repetitive mild traumatic brain injury (r-mTBI) has increasingly become recognised as a risk factor for the development of neurodegenerative diseases, many which are characterised by tau pathology, metal dyshomeostasis and behavioural impairments. We aimed to characterise status involvement iron in repetitive controlled cortical impact (5 impacts, 48 h apart) 3-month-old C57Bl6 mice at chronic (12-month) time point. performed battery tests, neurodegeneration-associated proteins (tau tau-regulatory proteins, amyloid precursor protein iron-regulatory proteins) via western blot; levels using bulk inductively coupled plasma-mass spectrometry (ICP-MS). report significant changes various ipsilateral following five but not single injury, increases contralateral iron, zinc copper impacts. There was no evidence pathology or although some were observed injury. Five impacts resulted gait deficits, anhedonia cognitive deficits 9-12 months post-injury, effects seen To best our knowledge, we first describe metals mouse model r-mTBI, providing strong indication towards an overall increase (and other metals) phase r-mTBI. These results bring question relevance highlight dysregulation and/or progression neurodegeneration may lead new therapeutic approaches future.

Language: Английский

Citations

3
Research Progress of Ionomics in Central Nervous System Diseases DOI Open Access

向楠 徐

Journal of Clinical Personalized Medicine, Journal Year: 2024, Volume and Issue: 03(04), P. 2161 - 2167

Published: Jan. 1, 2024

Language: Английский

Citations

0
AGEING RESEARCH REVIEWS (ARR-D-24-01334R1) Metabolic dysfunction contributes to mood disorders after traumatic brain injury DOI
Lang Liu,

Peijun Jia,

Tongzhou Liu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102652 - 102652

Published: Dec. 31, 2024

Language: Английский

Citations

0
Elemental Mapping in a Preclinical Animal Model Reveals White Matter Copper Elevation in the Acute Phase of Central Nervous System Trauma DOI
Cameron W. Evans,

Abigail Egid,

Somayra Mamsa

et al.

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(18), P. 3518 - 3527

Published: Sept. 11, 2023

Understanding the chemical events following trauma to central nervous system could assist in identifying causative mechanisms and potential interventions protect neural tissue. Here, we apply a partial optic nerve transection model of injury rats use synchrotron X-ray fluorescence microscopy (XFM) perform elemental mapping metals (K, Ca, Fe, Cu, Zn) other related elements (P, S, Cl) white matter tracts. The spatial precision allow us obtain previously unattained resolution changes response primary subsequent secondary effects. We observed significant elevation Cu levels at multiple time points injury, both site tissue near vulnerable damage, as well Cl, K, P, Ca. Our results suggest widespread metal dyshomeostasis that altered homeostasis may be specific event injury. findings highlight point intervention limiting damage

Language: Английский

Citations

0