Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12155 - 12155
Опубликована: Ноя. 12, 2024
The
interplay
between
functional
food
nutrients
and
neurosteroids
has
garnered
significant
attention
for
its
potential
to
enhance
stress
resilience
in
health
and/or
disease.
Several
bioactive
nutrients,
including
medicinal
herbs,
flavonoids,
bioavailable
polyphenol-combined
nanoparticles,
as
well
probiotics,
vitamin
D
omega-3
fatty
acids,
have
been
shown
improve
blood-brain
barrier
(BBB)
dysfunction,
endogenous
neurosteroid
homeostasis
brain
function.
These
can
inhibit
oxidative
neuroinflammation,
which
are
linked
the
pathogenesis
of
various
neurological
disorders.
Interestingly,
flavonoids
exhibit
dose-dependent
effects,
activating
nuclear
factor
erythroid
2-related
2
(Nrf2)
pathway
at
physiological/low
dose
(neurohormesis).
This
leads
upregulation
antioxidant
phase
II
genes
proteins
such
heme
oxygenase-1
(HO-1)
sirtuin-1
(Sirt1),
activated
by
curcumin
resveratrol,
respectively.
adaptive
neuronal
response
mechanisms
help
protect
against
reactive
oxygen
species
(ROS)
neurotoxicity.
Impaired
Nrf2
hormone
signaling
exacerbate
selective
vulnerability
neuroinflammatory
conditions,
contributing
onset
progression
neurodegenerative
psychiatric
disorders,
Alzheimer's
disease,
anxiety
depression
other
due
neurons
stress.
review
focuses
on
targeting
redox
regulate
BBB
damage
associated
with
altered
GABAergic
neurotransmission.
By
exploring
underlying
molecular
using
innovative
technologies,
we
aim
develop
promising
neuroprotective
strategies
personalized
nutritional
neuroregenerative
therapies
prevent
or
attenuate
ultimately
promoting
health.
Язык: Английский
Zebrafish: A trending model for gut-brain axis investigation
Aquatic Toxicology,
Год журнала:
2024,
Номер
270, С. 106902 - 106902
Опубликована: Март 17, 2024
Язык: Английский
The Neuroimmune Axis in Gastrointestinal Disorders – An Underrecognized Problem
Current Gastroenterology Reports,
Год журнала:
2025,
Номер
27(1)
Опубликована: Апрель 15, 2025
Язык: Английский
Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence
Pediatric Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 11, 2024
Язык: Английский
Improving neurological and mental health outcomes for children with prenatal drug exposure
Seminars in Fetal and Neonatal Medicine,
Год журнала:
2024,
Номер
unknown, С. 101557 - 101557
Опубликована: Ноя. 1, 2024
Язык: Английский
Toll-like receptors as a missing link in Notch signaling cascade during neurodevelopment
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Ноя. 27, 2024
Neurodevelopment
encompasses
a
complex
series
of
molecular
events
occuring
at
defined
time
points
distinguishable
by
the
specific
genetic
readout
and
active
protein
machinery.
Due
to
immense
intricacy
intertwined
pathways,
extracting
describing
all
components
single
pathway
is
demanding
task.
In
other
words,
there
always
risk
leaving
potential
transient
partners
unnoticed
while
investigating
signaling
cascades
with
core
functions-and
very
neglected
ones
could
be
turning
point
in
understanding
context
regulation
events.
For
example,
pathways
Notch
Toll-like
receptors
(TLRs)
have
been
so
far
unrelated
vast
body
knowledge
about
neurodevelopment,
however
evidence
from
available
literature
their
remarkable
overlap
influence
on
identical
processes
reveals
functional
links.
Based
data
demonstrating
TLR
structural
engagement
functions
during
along
our
description
novel
binding
models,
here
we
hypothesize
that
proteins
act
as
likely
crucial
cascade.
We
advocate
for
hypothesized
role
TLRs
by:
elaborating
features
pathways;
reviewing
effects
fates
neural
progenitor
cells
neurodevelopment;
proposing
aspects
hypothesis,
venues
testing
it.
Finally,
discuss
substantial
indications
environmental
proposed
Notch-TLR
system
its
impact
neurodevelopmental
outcomes.
Язык: Английский
The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
ABSTRACT
Autism
spectrum
disorders
(ASD)
affects
1
in
36
children
and
is
characterized
by
repetitive
behaviors
difficulties
social
interactions
communication.
The
etiology
of
ASD
extremely
heterogeneous,
with
a
large
number
cases
that
are
unknown
or
complex
etiology,
which
suggests
the
potential
contribution
epigenetic
risk
factors.
In
particular,
epidemiological
animal
model
studies
suggest
inflammation
during
pregnancy
could
lead
to
an
increased
offspring.
However,
molecular
mechanisms
contribute
pathogenesis
relation
maternal
humans
underexplored.
Several
pro-inflammatory
cytokines
have
been
associated
autistic-like
models
immune
activation,
including
IL-17A.
Using
combination
patient
lymphocytes
stem
cell-derived
human
neurons
exposed
IL-17A
we
discovered
shared
signature
highlights
metabolic
translational
node
altered
neuronal
excitability.
Further,
our
work
on
brings
forward
possibility
defects
DNA
damage
response
be
underlying
effect
excitatory
neurons,
linking
exacerbated
unrepaired
pathogenicity
connection
ASD.
Язык: Английский