Sustained
attention
deficits
were
reported
more
significant
in
patients
with
major
depressive
disorder
(MDD)
than
healthy
controls
(HCs),
and
are
pivotal
both
the
development
aggravation
of
depression.
Childhood
trauma
is
also
common
MDD
exposure
to
childhood
may
impede
sustained
increase
treatment
resistance
MDD.
However,
underlying
neuro-mechanisms
link
remain
unclear.
We
collected
resting-state
functional
magnetic
resonance
imaging
data,
measured
severity
using
Trauma
Questionnaire
Continuous
Performance
Test,
Identical
Pairs
version.
After
excluding
subjects
head
movement,
45
MDDs
54
HCs
included
analysis.
compared
fractional
amplitude
low-frequency
fluctuation
(fALFF)
between
groups,
conducted
whole-brain
correlation
analysis
fALFF
group,
defined
regions
as
interest
for
seed-to-whole
brain
connectivity
(FC)
further
performed
mediation
analyses
investigate
relationships
among
trauma,
FC
values,
level
group.
Compared
HCs,
exhibited
higher
right
middle
frontal
gyrus
left
inferior
gyrus,
lower
bilateral
insular
cortex,
medial
orbital
superior
angular
(ANG.L).
Whole-brain
showed
that
impaired
was
associated
increased
postcentral
(PoCG.L),
PoCG.L-left
precentral
(PreCG.L)
ANG.L-right
temporal
(STG.R)
Furthermore,
PoCG.L,
PoCG.L-PreCG.L
ANG.L-STG.R
mediated
relationship
The
might
be
potential
neural
substrate
association
poor
MDDs,
serve
intervention
targets
history.
EBioMedicine,
Год журнала:
2024,
Номер
106, С. 105255 - 105255
Опубликована: Июль 19, 2024
Controllability
analysis
is
an
approach
developed
for
evaluating
the
ability
of
a
brain
region
to
modulate
function
in
other
regions,
which
has
been
found
be
altered
major
depressive
disorder
(MDD).
Both
symptoms
and
cognitive
impairments
are
prominent
features
MDD,
but
case-control
differences
controllability
between
MDD
controls
can
not
fully
interpret
contribution
both
clinical
cognition
linked
patterns
among
them
MDD.
Major
depressive
disorder
demonstrated
sex
differences
in
prevalence
and
symptoms,
which
were
more
pronounced
during
adolescence.
Yet,
research
on
sex-specific
brain
network
characteristics
adolescent-onset
major
remains
limited.
This
study
investigated
nonspecific
alterations
resting-state
functional
connectivity
of
three
core
networks
(frontoparietal
network,
salience
default
mode
network)
subcortical
disorder,
using
seed-based
50
medication-free
patients
with
56
healthy
controls.
Irrespective
sex,
compared
controls,
showed
hypoconnectivity
between
bilateral
hippocampus
right
superior
temporal
gyrus
(default
network).
More
importantly,
we
further
found
that
females
exhibited
within
the
(medial
prefrontal
cortex),
regions
(i.e.
amygdala,
striatum,
thalamus)
(angular
posterior
cingulate
cortex)
frontoparietal
(dorsal
while
opposite
patterns
observed
males
relative
to
their
sex-matched
Moreover,
several
changes
correlated
age
onset,
sleep
disturbance,
anxiety
different
sex.
These
findings
suggested
these
may
reflect
development
or
processes
related
early
illness
underscoring
necessity
for
sex-tailored
diagnostic
therapeutic
approaches
disorder.
Bipolar Disorders,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 12, 2024
Bipolar
disorder
(BD)
is
a
highly
heritable
characterized
by
emotion
dysregulation
and
recurrent
oscillations
between
mood
states.
Despite
the
proven
efficacy
of
early
interventions,
vulnerability
markers
in
high-risk
individuals
are
still
lacking.
BD
patients
present
structural
alterations
hippocampus,
pivotal
hub
regulation
networks
composed
multiple
subregions
with
different
projections.
However,
hippocampal
dynamic
functional
connectivity
(dFC)
remains
unclear.
We
aim
to
investigate
whether
dFC
subdivisions
differentiates
patients,
offspring
(BDoff),
healthy
controls
(HC);
it
correlates
symptoms
differently
these
groups.
Human Brain Mapping,
Год журнала:
2024,
Номер
45(2)
Опубликована: Фев. 1, 2024
Recent
studies
have
suggested
that
emotional
reactivity
changes
with
age,
but
the
neural
basis
is
still
unclear.
The
insula
may
be
critical
for
reactivity.
current
study
examined
how
ageing
affects
using
task
data
from
a
human
sample
(Cambridge
Center
Age
and
Neuroscience,
N
=
243,
age
18-88
years).
resting-state
magnetic
resonance
measurements
same
were
used
to
investigate
potential
mechanisms
of
insula.
In
initial
analysis,
we
conducted
partial
correlation
assessments
examine
associations
between
as
well
gray
matter
volume
(GMV)
age.
Our
results
revealed
reactivity,
especially
positive
decreased
GMV
was
negatively
correlated
Subsequently,
bilateral
divided
into
six
subregions
calculate
whole
brain
functional
connectivity
(rsFC).
mediating
effect
rsFC
on
then
calculated.
showed
left
anterior
(AI)
right
hippocampus,
rsFCs
AI
striatum
thalamus
mediated
relationship
findings
suggest
attenuating
strategic
adaptation
fostering
stability
diminishing
vulnerability.
Meanwhile,
implicate
key
role
in
Frontiers in Psychology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 17, 2025
Post-traumatic
stress
disorder
(PTSD)
symptomatology
has
historically
been
considered
a
psychic
ailment
that
is
part
of
mental
disorder.
However,
it
often
proposed
could
play
an
adaptive
role,
in
would
prevent
individuals
from
being
exposed
to
content
or
situations
they
not
be
prepared
process.
Within
the
literature
on
emotional
regulation
(ER),
PTSD
commonly
linked
concept
dysregulation
(ED).
some
definitions
open
possibility
traumatic
ER,
which
delicate
conclusions
follow.
To
resolve
this
dilemma,
we
turn
interdisciplinary
dialogue,
specifically
with
aid
Thomistic
anthropology,
whose
concepts
allow
us
understand
precisely
relationship
between
voluntary
and
involuntary
processes
close
reason
regulation.
Even
though
involves
mechanisms
aimed
at
modifying
states,
concluded
necessary
continue
conceptualizing
as
ED.
The
theoretical
practical
implications
discussion
are
reviewed.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2025,
Номер
169, С. 106030 - 106030
Опубликована: Фев. 1, 2025
Bipolar
disorder
(BD)
is
characterized
by
a
complex
constellation
of
emotional,
cognitive,
and
psychomotor
disturbances,
each
deeply
intertwined
with
underlying
dysfunctions
in
large-scale
brain
networks
neurotransmitter
systems.
This
manuscript
integrates
recent
advances
neuroimaging,
neuromodulation,
pharmacological
research
to
provide
comprehensive
view
BD's
pathophysiology,
emphasizing
the
role
network-specific
their
clinical
manifestations.
We
explore
how
dysregulation
within
fronto-limbic
network,
particularly
involving
prefrontal
cortex
(PFC)
amygdala,
underpins
emotional
instability
that
defines
both
manic
depressive
episodes.
Additionally,
impairments
central
executive
network
(CEN)
default
mode
(DMN)
are
linked
cognitive
deficits,
hyperactivity
DMN
driving
rumination
inflexibility,
while
CEN
underactivity
contributes
attentional
lapses
impaired
function.
Psychomotor
symptoms,
which
oscillate
between
mania
retardation
depression,
closely
associated
imbalances
systems,
dopamine
serotonin,
basal
ganglia-thalamo-cortical
motor
pathway.
Recent
studies
indicate
these
disturbances
further
exacerbated
disruptions
connectivity,
leading
control
regulation.
Emerging
therapeutic
strategies
discussed,
focus
on
neuromodulation
techniques
such
as
transcranial
magnetic
stimulation
(TMS)
deep
(DBS),
show
promise
restoring
balance
critical
networks.
Furthermore,
interventions
modulate
synaptic
functioning
neuronal
plasticity
offer
potential
for
addressing
symptoms
BD.
underscores
need
an
integrative
treatment
approach
simultaneously
targets
neural
circuits
systems
address
full
spectrum
Drawing
advancements
neurobiological
models
frameworks,
this
proposal
outlines
pathway
development
precision-tailored
interventions.
These
approaches
designed
optimize
outcomes,
ultimately
striving
elevate
quality
life
individuals
living
bipolar
(BD),
remaining
firmly
grounded
latest
empirical
evidence
theoretical
insights.
