Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
The
human
body
contains
approximately
100
trillion
microorganisms,
predominantly
within
the
gastrointestinal
tract,
collectively
called
gut
microbiota.
Investigations
have
revealed
bidirectional
communication
between
microbiota
and
brain,
characterized
as
"microbiota-gut-brain
axis."
This
axis
represents
an
important
regulator
of
brain
development
function,
immune
system
development,
nutrient
metabolism,
making
it
a
target
for
efforts
to
alleviate
progression
neurodegenerative
diseases
(NDDs).
Despite
extensive
biomedical
clinical
research,
our
understanding
causes,
optimal
treatment,
NDDs
remains
limited.
paper
aims
summarize
available
knowledge
on
role
played
by
how
is
connected
conditions;
in
particular,
relationship
gut-brain
communications
neuro-immune
conditions
reviewed.
We
discuss
why
communicates
with
this
impacts
neurodegeneration.
Next,
we
examine
alterations
microbiota,
response,
changes
associated
dysbiosis.
Finally,
highlight
preclinical
evidence
probiotics,
prebiotics,
fecal
transplantation,
dietary
supplements,
natural
drugs,
exercise
intervention
potential
therapeutic
approaches
that
could
lead
new
treatment
paradigm
NDDs.
Язык: Английский
Multi-omics analysis reveals the potential mechanisms underlying long-term exercise-induced enhancement of learning and memory in male mice
Biogerontology,
Год журнала:
2025,
Номер
26(2)
Опубликована: Март 30, 2025
Язык: Английский
Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and healthcare
hLife,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Effects and mechanisms of esketamine on depression by targeting gut microbiota: A narrative review
New discovery.,
Год журнала:
2025,
Номер
unknown, С. 1 - 7
Опубликована: Апрель 29, 2025
Depression
is
a
severe
and
recurrent
neuropsychiatric
disease
with
high
prevalence,
disability,
mortality,
which
imposes
heavy
burden
on
national
public
health
the
economy.
Traditional
antidepressants
demonstrate
delayed
effects,
low
cure
rates,
inadequate
therapeutic
effectiveness
for
managing
treatment-resistant
depression.
Numerous
studies
have
proved
that
esketamine,
non-competitive
N-methyl-D-aspartate
receptor
antagonist,
can
produce
rapid
sustained
antidepressant
effect,
was
approved
by
FDA
EMA
in
2019
2020,
respectively.
However,
pharmacological
mechanism
underlying
effects
of
esketamine
remains
inadequately
understood.
Previous
shown
gut
microbiota
plays
significant
role
central
nervous
system
regulation
such
as
emotional
behavior
cognitive
function.
Moreover,
fecal
transplantation
alleviate
depression
regulating
disorder
microbiota.
Notably,
exhibited
effect
against
modulating
its
metabolites.
Therefore,
this
review
summarized
current
research
progress
functional
treatment
depression,
well
discussed
esketamine’s
Язык: Английский
The Influence of Intestinal Microbiota on BDNF Levels
Nutrients,
Год журнала:
2024,
Номер
16(17), С. 2891 - 2891
Опубликована: Авг. 29, 2024
The
regulation
of
neurogenesis,
the
complex
process
producing
and
differentiating
new
brain
tissue
cells,
is
influenced
by
a
interaction
internal
external
factors.
Over
past
decade,
extensive
research
has
been
conducted
on
neurotrophins
their
key
role
in
adult
as
well
impact
diseases
such
depression.
Among
neurotrophins,
brain-derived
neurotrophic
factor
(BDNF)
subject
comprehensive
studies
scientific
evidence
supports
its
necessity
for
neurogenesis
subventricular
zone
hippocampus.
A
novel
area
emerging
gut
microbiota
significant
contributor
to
neurotrophin
production.
Studies
have
shown
that
reduced
BDNF
levels
can
lead
mood
disorders,
which
are
observed
intestinal
dysbiosis,
characterized
an
imbalance
composition
quantity
microbiota.
There
literature
there
link
between
function
Physical
activity,
especially
regularity
intensity
exercise,
important
relation
level
Probiotics,
prebiotics
physical
activity
may
positive
effect
microbiota,
therefore
also
factor.
Язык: Английский
Gut-Brain Axis to Investigate the Effects of Gut Health on Cognitive Functioning in Adults
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 10, 2024
Introduction:
The
gut-brain
axis
is
a
bidirectional
communication
network
linking
the
gastrointestinal
tract
and
central
nervous
system
via
neuronal,
hormonal,
antibody
signaling
pathways.
Central
to
this
connection
gut
health,
encompassing
balance
functionality
of
microbiota,
which
significantly
impacts
on
mental
cognitive
health.
This
study
investigates
association
between
health
functioning
in
adults,
highlighting
mechanisms
by
microbiota
influence
brain
Objective:
To
examine
effects
adult
performance,
with
focus
processes
Methods:
A
quantitative
cross-sectional
was
conducted
Islamabad
from
January
2024
April
2024,
involving
140
participants.
Data
were
collected
using
comprehensive
16-item
questionnaire
cognition
self-assessment
rating
scale
(C-SARS).
psychometric
properties
these
scales
assessed,
data
analyzed
Statistical
Product
Service
Solutions
(SPSS,
v26;
IBM
SPSS
Statistics
for
Windows,
Armonk,
NY).
Analytical
descriptive
statistics,
including
regression,
chi-square,
independent
sample
t-tests,
mean
standard
deviation,
applied.
Results:
found
moderate
associations
particularly
memory
processing
speed
(R²
=
0.17,
β
-1.9,
p
0.12
general
cognition;
R²
0.01,
-0.98,
0.02
memory;
0.03,
-0.18,
0.03
speed).
Gender
marital
status
differences
significant,
males
exhibiting
better
scores
than
females
(M
34.1,
SD
3.2
vs.
M
31.2,
3.2,
0.00),
singles
showing
performance
compared
married
individuals
9.4,
5.4
6.5,
3.7,
0.03).
Conclusion:
highlights
significant
functions,
suggesting
that
composition
can
performance.
underscore
need
consider
individual
research.
Future
studies
should
replicate
findings
larger
samples
explore
microbiota-targeted
interventions
enhancement.
Язык: Английский
COMPORTAMENTO ALIMENTAR E A RELAÇÃO ENTRE O INTESTINO E O CÉREBRO
RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218,
Год журнала:
2024,
Номер
5(1), С. e516076 - e516076
Опубликована: Дек. 4, 2024
A
relação
entre
alimentação
e
saúde
mental
tem
ganhado
destaque
nas
pesquisas
científicas,
especialmente
no
que
diz
respeito
à
interconexão
o
intestino
cérebro.
microbiota
intestinal,
composta
por
trilhões
de
microrganismos,
interage
maneira
complexa
com
sistema
nervoso
central
(SNC)
meio
vias
neurais,
hormonais
imunológicas.
Com
base
em
um
guia
nutrição
clínica,
fica
evidente
a
intervenção
dietética
pode
otimizar
função
do
eixo
microbiota-intestino-cérebro,
promovendo
tanto
digestiva
quanto
mental.
análise
das
interações
dieta,
contribuir
para
desenvolvimento
abordagens
inovadoras
tratamento
condições
neuropsiquiátricas.
O
objetivo
desta
monografia
é
investigar
comportamental
intestino-cérebro,
foco
intestinal
mental,
através
uma
revisão
da
literatura,
pretendendo
identificar
evidências
sustentem
hipótese
saudável
promover
microbioma
saudável,
contribuindo
prevenção
manejo
distúrbios
neuropsiquiátricos,
como
depressão
ansiedade.
Conclui-se
estudo
comportamento
alimentar
sua
intestino-cérebro
revela
bem-estar
Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression
Neural Regeneration Research,
Год журнала:
2024,
Номер
20(12), С. 3416 - 3429
Опубликована: Дек. 16, 2024
Parkinson’s
disease
has
long
been
considered
a
disorder
that
primarily
affects
the
brain,
as
it
is
defined
by
dopaminergic
neurodegeneration
in
substantia
nigra
and
brain
accumulation
of
Lewy
bodies
containing
α-synuclein
protein.
In
recent
decades,
however,
accumulating
research
revealed
also
involves
gut
uncovered
an
intimate
important
bidirectional
link
between
gut,
called
“gut–brain
axis.”
Numerous
clinical
studies
demonstrate
dysfunction
frequently
precedes
motor
symptoms
patients,
with
findings
including
impaired
intestinal
permeability,
heightened
inflammation,
distinct
microbiome
profiles
metabolites.
Furthermore,
deposition
consistently
observed
suggesting
potential
role
initiation.
Importantly,
individuals
vagotomy
have
reduced
risk.
From
these
observations,
researchers
hypothesized
may
initiate
subsequently
propagate
to
central
neurons
through
gut–brain
axis,
leading
disease.
This
review
comprehensively
examines
gut’s
involvement
disease,
focusing
on
concept
gut-origin
for
We
examine
interplay
altered
gut-related
factors
pathological
patients.
Given
accessibility
both
dietary
pharmacological
interventions,
targeting
gut-localized
represents
promising
avenue
developing
effective
therapies.
Язык: Английский