Bifidobacterium bifidum CCFM1163 Alleviates Cathartic Colon by Activating the BDNF-TrkB-PLC/IP3 Pathway to Reconstruct the Intestinal Nerve and Barrier

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Cathartic colon (CC) is a type of slow-transit constipation caused by patient's long-term use irritating laxatives. Probiotics play crucial role in managing constipation.

Язык: Английский

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The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract Chronic migraine is one of the most common pain disorders, characterized by significant disability and a lack safe, long‐term, effective treatment options. Recent studies highlight interaction between lung microbiota central nervous system. In this study, nitroglycerin (NTG)‐induced chronic model constructed in male C57BL/6 mice to explore these interactions. Notable alterations are observed migraine‐afflicted mice. Notably, there marked decrease Proteobacteria group, associated with short‐chain fatty acids 5‐hydroxytryptamine (5‐HT). After intratracheal injection neomycin, diversity altered, resulting relief migraines. This effect also that receive neomycin‐treated bronchoalveolar lavage fluid (BALF) transplantation, further demonstrating role process. The altered activate pulmonary vagus nerve via Brain‐derived neurotrophic factor‐tropomyosin receptor kinase B (BDNF‐TrkB) pathway lung, which projects nucleus solitary tract (NTS) dorsal raphe (DRN). activation, turn, stimulates 5‐HT neurons DRN, increased serotonin levels contribute model.

Язык: Английский

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Exercise, Diet, and Brain Health: From the Perspective of Gut Microbiota Regulation

Nutrients, Год журнала: 2025, Номер 17(10), С. 1686 - 1686

Опубликована: Май 15, 2025

The existing body of evidence has highlighted gut microbiota as a versatile regulator wellness affecting not only multiple physiological metabolisms but also the function remote organs. Emerging studies revealed reciprocal relationship between physical exercise and intestinal microbiota, suggesting that could enhance health, including regulating barrier integrity, increasing microbial diversity, promoting beneficial metabolism. Furthermore, outcomes on intestine may promote brain health through gut-brain axis. Diet is an important factor in boosting performance greatly impacts structure microbiota. Abundant research reported diet alongside exert effects metabolism, immune regulation, neuropsychiatric system. In this paper, we used narrative review, primarily searching PubMed, Web Science, Elsevier, to review how moderate-intensity promotes introduced nervous system We proposed dietary strategies targeting regulation provide guidelines for health. This highlights moderate healthy

Язык: Английский

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Randomized controlled trial evaluating synbiotic supplementation as an adjuvant therapy in the treatment of Parkinson’s disease

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Язык: Английский

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