Опубликована: Июль 26, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 8, 2025
Язык: Английский
Процитировано
5
Smart Materials in Medicine, Год журнала: 2024, Номер 5(2), С. 183 - 195
Опубликована: Янв. 12, 2024
Since the need for vascular networks to supply oxygen and nutrients while expelling metabolic waste, most cells can only survive within 200 μm of blood vessels; thus, construction well-developed vessel is essential manufacture artificial tissues organs. Three-dimensional (denoted as 3D) printing a scalable, reproducible high-precision manufacturing technology. In past several years, there have been many breakthroughs in building various vascularized tissues, greatly promoting development biological tissue engineering. This paper highlights latest progress 3D printed organs, including heart, liver, lung, kidney, penis. We also discuss application status potential above prospect further requirement technology clinically useable tissues.
Язык: Английский
Процитировано
17
ACS Sensors, Год журнала: 2024, Номер 9(7), С. 3466 - 3488
Опубликована: Июль 11, 2024
Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology also facing notable challenges, such as lack vascularization, development multiorgan-on-a-chip systems, replication body single chip. The progress has played crucial role in steering OOC toward mimicking microenvironment, including microenvironment replication, multiorgan microphysiological systems. Additionally, advancements detection, analysis, organoid imaging technologies have enhanced efficiency Organs-on-Chips (OOCs). In particular, integration artificial intelligence revolutionized imaging, significantly enhancing high-throughput drug screening. Consequently, review covers research Human-on-a-chip, sensors OOCs, latest applications biomedical field.
Язык: Английский
Процитировано
15
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101515 - 101515
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4529 - 4529
Опубликована: Фев. 25, 2023
Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality worldwide. Bi-dimensional in vitro models unable to recapitulate key features PLC; consequently, recent advancements three-dimensional systems, such as organoids, opened up new avenues for development innovative studying tumour’s pathological mechanisms. Liver organoids show self-assembly self-renewal capabilities, retaining essential aspects their respective vivo tissue allowing modelling diseases personalized treatment development. In this review, we will discuss current advances field focusing on existing protocols possible applications regenerative medicine drug discovery.
Язык: Английский
Процитировано
16
Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)
Опубликована: Сен. 27, 2024
Abstract Over the past decade, organoids have emerged as a prevalent and promising research tool, mirroring physiological architecture of human body. However, field advances, traditional use animal or tumor-derived extracellular matrix (ECM) scaffolds has become increasingly inadequate. This shift led to focus on developing synthetic scaffolds, particularly hydrogels, that more accurately mimic three-dimensional (3D) tissue structures dynamics in vitro. The ECM–cell interaction is crucial for organoid growth, necessitating hydrogels meet organoid-specific requirements through modifiable physical compositional properties. Advanced composite been engineered effectively replicate vivo conditions, offering accurate representation organs compared matrices. review explores evolution current uses decellularized ECM emphasizing application culture. It also fabrication prospects their future systems.
Язык: Английский
Процитировано
4
Gels, Год журнала: 2024, Номер 10(10), С. 653 - 653
Опубликована: Окт. 12, 2024
Biomedical engineering, especially tissue is trying to provide an alternative solution generate functional organs/tissues for use in various applications. These include beyond the final goal of transplantation, disease modeling and drug discovery as well. The aim this study comprehensively review existing literature on hydrogel-based vascularized organ (i.e., liver, pancreas, kidneys, intestine, stomach spleen) engineering abdominal organs.
Язык: Английский
Процитировано
4
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 35 - 35
Опубликована: Янв. 19, 2025
This research introduced a strategy to fabricate sub-millimeter-diameter artificial liver tissue by extruding combination of decellularized extracellular matrix (dECM), alginate, endothelial cells, and hepatocytes. Vascularization remains critical challenge in engineering, as replicating the liver’s intricate vascular network is essential for sustaining cellular function viability. Seven scaffold groups were evaluated, incorporating different cell compositions, materials, structural configurations. The hepatocyte treated with alginate lyase demonstrated highest diffusion rate, along enhanced albumin secretion (2.8 µg/mL) urea synthesis (220 during same period day 10. A dense interconnected was observed early 4 lyased coculture group. Furthermore, three-week implantation studies rats showed stable integration host no adverse effects. approach offers significant potential advancing functional replacements, combining accelerated diffusion, secretion, improved synthesis, formation, outcomes.
Язык: Английский
Процитировано
0
Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112260 - 112260
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Bio-Design and Manufacturing, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
0